Neoplasms

Blood and Lymph Conditions

All Conditions

Rare Diseases

Leukemia

Leukemia, Myeloid

Leukemia, Myeloid, Acute

Neoplasms by Histologic Type

Hematologic Diseases

Myeloid Leukemia

Acute Myeloid Leukemia

Acute Non Lymphoblastic Leukemia

Acute Graft Versus Host Disease

Therapeutic platelet transfusion (TP) strategy versus prophylactic platelet transfusion (PP) strategy. In the TP arm platelet transfusion is only required if bleeding occurs (more than petechial)or in case of pulmonary infections with or without sepsis.

In the PP arm platelet transfusion has to be performed when platelet count is below 10.000/µL in any case and when bleeding (more than petechial) occurs.

Prophylactic platelet transfusion

In the TP arm platelet transfusion is only required if bleeding occurs (more than petechial)or in case of pulmonary infections with or without sepsis.

Therapeutic platelet transfusion

Gerhard Ehninger, Prof.

The purpose of this study is to show that a therapeutic platelet transfusion strategy (i.e. platelet transfusion only in case of bleeding) needs minimally a quarter less of transfusions compared to the standard prophylactic transfusion strategy (i.e. platelet transfusion without any sign of bleeding when the platelet count is below 10.000/µL). With the experimental transfusion strategy transfusions could be safely reduced when the study hypothesis can be proven. This is the first prospective randomized study on this topic.

A Trial Comparing a Prophylactic With a Therapeutic Platelet Transfusion Strategy in Two Groups

Prospective Randomized Trial Comparing a Prophylactic With a Therapeutic Platelet Transfusion Strategy in Two Groups: 1)in Patients With Acute Myeloid Leukemia After Intensive Chemotherapy and 2) After Autologous Blood Stem Cell Transplantation

Technische Universität Dresden

Katrin Peschel

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
A Trial Comparing a Prophylactic With a Therapeutic Platelet Transfusion Strategy in Two Groups	NCT00521664	Myeloid Leukemi...	Prophylactic pl... Therapeutic pla...	16 Years - 80 Years	Technische Universität Dresden
A Trial Comparing a Prophylactic With a Therapeutic Platelet Transfusion Strategy in Two Groups	NCT00521664	Myeloid Leukemi...	Prophylactic pl... Therapeutic pla...	16 Years - 80 Years	Technische Universität Dresden

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