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Cola

30 patients with non-medullary thyroid carcinoma, who are going to get surgery

30 participants with colon carcinoma, who are going to get surgery

no intervention will take place

RadboudUMC P van Houten, Msc.

Tumor-related inflammation is one of the hallmarks of cancers in general. Innate immunity specifically is a common denominator which is involved in the pathogenesis of both thyroid carcinoma and colon carcinoma. To improve the patient's outcome and identify novel therapeutic targets, one needs a deeper understanding of the tumor-induced changes in the bone marrow myeloid progenitor cells. Furthermore, treatment of these cells by nanoparticles or other agents that induce a program of 'trained immunity' may be a novel way to re-educate myeloid cells and their bone marrow progenitors in thyroid carcinoma patients. Lastly, the investigators expect that this approach could be effective also in other cancers of which colon carcinoma is here proposed as an additional model.

The investigators hypothesize that by exposing myeloid cells or their progenitors to various agents that induce trained immunity (e.g. high-density-lipoprotein-methylene diphosphonate nanoparticles, recombinant and synthetic cytokines), these immune cells will undergo functional reprogramming to induce a tumor-suppressive phenotype. In the future, this could be explored as a novel immunotherapy for tumors that are refractory to conventional treatment.

Trained Immunity in Thyroid Carcinoma and Colon Carcinoma

Trained Immunity of Myeloid Cells and Their Progenitors in Patients With Non-medullary Thyroid Carcinoma and Colon Carcinoma

Levels of thyroid stimulating hormone (TSH), measured in mili unit/Liter. Only measured in the patients with thyroid carcinoma.

Levels of carcino-embryonal antigen (CEA), measured in ug/Liter. Only measured in patients with colon carcinoma.

Levels of pro-inflammatory cytokines en chemokines such as tumor necrosis factor-alfa,interleukin(IL)-1beta and IL-6 will be measured (pg/miliLiter) before and after induction of trained immunity. This will happen after 1 and after 7 days. These will be measured using ELISA.

Radboud University Medical Center

Symptoms and General Pathology

Disease Susceptibility

Disease Attributes

at inclusion visit :

- Blood collection for whole Genome sequencing will be performed

At final visit :

the results of the WGS will be delivered to patients

The purpose of this research is to find new predisposition genes for differentiated thyroid cancer (DTC).

The purpose of this research is to find new predisposition genes for differentiated thyroid cancer (DTC). Therefore, in the absence of a BAP1 and DICER1 abnormality, we offer to sequence your whole genome (WGS) or partial genome (genotyping) for a previously unknown genetic abnormality.

Furthermore, the discovery of new genes would be a major medical advance that could contribute to the identification of new therapeutic targets.

This research will be conducted at the University Hospital of Nantes and the Hospital of Vendée and 95 people should participate.

IDEntification of New Predisposition Genes in Differentiated THYroid Cancer

To be achieved by a whole genome sequencing (WGS) approach in a familial analysis of patients with differentiated thyroid cancer. In addition, high-throughput genotyping of multiple individuals in each family will allow complementary detection of genomic regions that are shared only by affected subjects

By studying the association between the clinical characteristics of patients and the identified genetic variants

Definition of the spatial location of family forms of CDT and to identify possible founding effects

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Trained Immunity in Thyroid Carcinoma and Colon Carcinoma	NCT05280379	Thyroid Cancer,... Colon Carcinoma	no intervention...	18 Years -	Radboud University Medical Center
IDEntification of New Predisposition Genes in Differentiated THYroid Cancer	NCT05014698	Differentiated ... Thyroid Cancer,...	WGS	8 Years -	Nantes University Hospital

Spots Global Cancer Trial Database for thyroid cancer, nonmedullary