Symptoms and General Pathology

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Low Anterior Resection Syndrome

Rectal Neoplasms

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

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Rectal Diseases

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Cola

After purse-string suture and ligation of the head of the stapler at the colonic end, 5cm away from the colonic end, 5cm longitudinal incision was made to the proximal end of the teniae coli in the anterior wall of the colon, transverse suture was performed, and the plasmomuscular layer was embedded, then end to end colon-rectum (or anal canal) anastomosis was performed

End to end colon-rectum (or anal canal) anastomosis was performed routinely

a transverse coloplasty pouch was performed before end to end colon-rectum (or anal canal) anastomosis

transverse coloplasty pouch

Bo Wei, M.D

Hongbo Wei, Ph.D

The incidence of prerectal resection syndrome (LARS) after middle and low rectal cancer surgery is as high as 70%, which seriously affects the quality of life of patients. Studies have shown that colon pouch can reduce and alleviate LARS symptoms. However, most previous studies focused on open surgery, and the evaluation index lacked objectivity. Therefore, in the context of minimally invasive rectal cancer surgery, it is necessary to re-evaluate the value of improved surgical methods for the prevention of LARS, so as to improve the quality of life of patients.

The incidence of prerectal resection syndrome (LARS) after middle and low rectal cancer surgery is as high as 70%, which seriously affects the quality of life of patients. LARS may be related to the injury of anal internal sphincter, anal sensory nerve injury, defecation reflex pathway injury, changes in anorectal Angle and rectum sigmoid Angle, changes in new rectal sensory function and compliance, and changes in dynamics,etc. After AR surgery, the rectum loses its good compliance and the storage capacity is reduced, which is one of the important reasons for the increased frequency and urgency of defecation.Therefore, on the basis of traditional colon-rectum (or anal canal) end-to-end anastomosis, "J" shaped pouch anastomosis, end-to-end anastomosis, coloplasty and other special anastomosis methods were performed. Meanwhile, for the lack of objective evaluation index, the results were not credible. The LARS score was first published in 2012,and has been validated, evaluated, or used as an outcome measure in more than 30 published scientific papers. Further more,laparoscopic surgery is widely used in gastrointestinal surgery. Herein, current randomized controlled trial comparing coloplasty with straight colorectal anastomosis in LARS in order to guide clinical practise was conducted.

The Effect of Different Reconstruction Methods on Anterior Resection Syndrome

The Effect of Different Reconstruction Methods in Laparoscopic Anterior Rectal Resection on Postoperative Anterior Resection Syndrome：a Randomized Controlled Trial

Anastomotic fistula, Hemorrhage, Pulmonary infection，Death

Time interval from surgery to flatus and defecation

Anastomotic fistula, Hemorrhage，Intestinal obstruction

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
The Effect of Different Reconstruction Methods on Anterior Resection Syndrome	NCT04023448	Rectal Cancer Low Anterior Re...	transverse colo...	20 Years - 80 Years	Third Affiliated Hospital, Sun Yat-Sen University
The Effect of Different Reconstruction Methods on Anterior Resection Syndrome	NCT04023448	Rectal Cancer Low Anterior Re...	transverse colo...	20 Years - 80 Years	Third Affiliated Hospital, Sun Yat-Sen University

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