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Spots Global Cancer Trial Database for Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

Official Title: OptimICE-PCR: De-Escalation of Therapy in Early-Stage TNBC Patients Who Achieve pCR After Neoadjuvant Chemotherapy With Checkpoint Inhibitor Therapy

Study ID: NCT05812807

Study Description

Brief Summary: The phase III trial compares the effect of pembrolizumab to observation for the treatment of patients with early-stage triple-negative breast cancer who achieved a pathologic complete response after preoperative chemotherapy in combination with pembrolizumab. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial may help researchers determine if observation will result in the same risk of cancer coming back as pembrolizumab after surgery in triple-negative breast cancer patients who achieve pathologic complete response after preoperative chemotherapy with pembrolizumab.

Detailed Description: PRIMARY OBJECTIVES: I. To evaluate whether observation results in a non-inferior recurrence-free survival (RFS) compared to adjuvant pembrolizumab in early-stage triple-negative breast cancer (TNBC) patients who achieve a pathologic complete response (pCR) after neoadjuvant chemotherapy with pembrolizumab. II. To compare quality of life (QOL) at approximately 27 weeks as assessed by the Functional Assessment of Cancer Therapy-Breast (FACT-B) Trial Outcome Index between patients randomized to adjuvant pembrolizumab versus observation. (Quality of Life) III. To assess the social value of de-escalation of adjuvant breast cancer immunotherapy at approximately 27 weeks and, by modeling, over a lifetime. (Value of Care) SECONDARY OBJECTIVES: I. To evaluate whether observation compared to adjuvant pembrolizumab impacts the following: Ia. RFS by stage at presentation and by receipt of prior anthracycline therapy; Ib. Adverse event rate: difference in Grade 3 or higher adverse event rates overall and Grade 3 or higher immune-related adverse events (irAEs) rates; Ic. Overall Survival (OS); Id. Locoregional recurrence (LRR both isolated LRR as first events and LRR events simultaneous with DM); Ie. RFS, LRR, OS, adverse events, and QOL by age (=\< 45, 46-65, and \> 65), race, and ethnicity; If. Adverse events related to receipt of radiotherapy. II. To assess the value of de-escalation of breast cancer immunotherapy from the payer perspective at approximately 27 weeks and, by modelling, over a lifetime. (Value of Care) III. To compare patient out-of-pocket costs at approximately 27 weeks between patients randomized to adjuvant pembrolizumab versus observation. (Value of Care) IV. To compare financial toxicity at approximately 27 weeks between patients randomized to adjuvant pembrolizumab versus observation. (Value of Care) V. To compare work/productivity impairment at approximately 27 weeks between patients randomized to adjuvant pembrolizumab versus observation. (Value of Care) EXPLORATORY OBJECTIVES: I. To describe trajectories of QOL over time among patients randomized to adjuvant pembrolizumab versus (vs.) observation. (Quality of Life) II. To compare various QOL domains after approximately 27 weeks as assessed by the 5 subscales of the FACT-B Index between patients randomized to adjuvant pembrolizumab versus observation. (Quality of Life) III. To compare self-reported symptomatic adverse events at approximately 27 weeks assessed by the patient reported outcome Common Terminology Criteria for Adverse Events (PRO-CTCAE) between patients randomized to adjuvant pembrolizumab versus observation. (Quality of Life) IV. To describe trajectories of financial toxicity and work/productivity impairment over time from baseline to approximately 27 weeks among patients randomized to adjuvant pembrolizumab versus observation. (Value of Care) V. To develop and assess a measure of value from the patient perspective at approximately 27 weeks. (Value of Care) OUTLINE: Patients are randomized to 1 of 2 arms after completing neoadjuvant chemotherapy in combination with pembrolizumab, followed by definitive breast surgery. ARM I (PEMBROLIZUMAB): Patients receive pembrolizumab intravenously (IV) on study. Patients also undergo tumor biopsy on study, and collection of blood on study and during follow-up. ARM II (OBSERVATION): Patients undergo observation on study. Patients also undergo tumor biopsy on study, and collection of blood on study and during follow-up.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

University of Alabama at Birmingham Cancer Center, Birmingham, Alabama, United States

Thomas Hospital, Fairhope, Alabama, United States

Mobile Infirmary Medical Center, Mobile, Alabama, United States

Kingman Regional Medical Center, Kingman, Arizona, United States

Cancer Center at Saint Joseph's, Phoenix, Arizona, United States

Mayo Clinic Hospital in Arizona, Phoenix, Arizona, United States

Highlands Oncology Group - Fayetteville, Fayetteville, Arkansas, United States

University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States

Highlands Oncology Group - Rogers, Rogers, Arkansas, United States

Highlands Oncology Group, Springdale, Arkansas, United States

PCR Oncology, Arroyo Grande, California, United States

Tower Cancer Research Foundation, Beverly Hills, California, United States

Marshall Cancer Center, Cameron Park, California, United States

Kaiser Permanente Dublin, Dublin, California, United States

Kaiser Permanente-Fremont, Fremont, California, United States

Kaiser Permanente-Fresno, Fresno, California, United States

Cedars Sinai Medical Center, Los Angeles, California, United States

Fremont - Rideout Cancer Center, Marysville, California, United States

Kaiser Permanente-Modesto, Modesto, California, United States

Kaiser Permanente-Oakland, Oakland, California, United States

Desert Regional Medical Center, Palm Springs, California, United States

Stanford Cancer Institute Palo Alto, Palo Alto, California, United States

Huntington Memorial Hospital, Pasadena, California, United States

Kaiser Permanente-Roseville, Roseville, California, United States

Kaiser Permanente Downtown Commons, Sacramento, California, United States

University of California Davis Comprehensive Cancer Center, Sacramento, California, United States

Kaiser Permanente-South Sacramento, Sacramento, California, United States

Salinas Valley Memorial, Salinas, California, United States

Zuckerberg San Francisco General Hospital, San Francisco, California, United States

Kaiser Permanente-San Francisco, San Francisco, California, United States

Kaiser Permanente-Santa Teresa-San Jose, San Jose, California, United States

Stanford Cancer Center South Bay, San Jose, California, United States

Kaiser Permanente San Leandro, San Leandro, California, United States

Kaiser San Rafael-Gallinas, San Rafael, California, United States

Kaiser Permanente Medical Center - Santa Clara, Santa Clara, California, United States

Saint John's Cancer Institute, Santa Monica, California, United States

Kaiser Permanente-Santa Rosa, Santa Rosa, California, United States

Kaiser Permanente-South San Francisco, South San Francisco, California, United States

Cedars-Sinai Cancer - Tarzana, Tarzana, California, United States

Torrance Memorial Physician Network - Cancer Care, Torrance, California, United States

Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee, California, United States

Kaiser Permanente-Vallejo, Vallejo, California, United States

Kaiser Permanente-Walnut Creek, Walnut Creek, California, United States

UCHealth University of Colorado Hospital, Aurora, Colorado, United States

UCHealth Memorial Hospital Central, Colorado Springs, Colorado, United States

Memorial Hospital North, Colorado Springs, Colorado, United States

Kaiser Permanente-Franklin, Denver, Colorado, United States

UCHealth - Cherry Creek, Denver, Colorado, United States

UCHealth Highlands Ranch Hospital, Highlands Ranch, Colorado, United States

Kaiser Permanente-Rock Creek, Lafayette, Colorado, United States

Kaiser Permanente-Lone Tree, Lone Tree, Colorado, United States

UCHealth Lone Tree Health Center, Lone Tree, Colorado, United States

Danbury Hospital, Danbury, Connecticut, United States

Smilow Cancer Hospital-Derby Care Center, Derby, Connecticut, United States

Smilow Cancer Hospital Care Center-Fairfield, Fairfield, Connecticut, United States

Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury, Connecticut, United States

Smilow Cancer Hospital Care Center at Greenwich, Greenwich, Connecticut, United States

Smilow Cancer Hospital Care Center - Guilford, Guilford, Connecticut, United States

Smilow Cancer Hospital Care Center at Saint Francis, Hartford, Connecticut, United States

Yale University, New Haven, Connecticut, United States

Yale-New Haven Hospital North Haven Medical Center, North Haven, Connecticut, United States

Norwalk Hospital, Norwalk, Connecticut, United States

Smilow Cancer Hospital Care Center at Long Ridge, Stamford, Connecticut, United States

Smilow Cancer Hospital-Torrington Care Center, Torrington, Connecticut, United States

Smilow Cancer Hospital Care Center-Trumbull, Trumbull, Connecticut, United States

Smilow Cancer Hospital-Waterbury Care Center, Waterbury, Connecticut, United States

Smilow Cancer Hospital Care Center - Waterford, Waterford, Connecticut, United States

Beebe South Coastal Health Campus, Frankford, Delaware, United States

Helen F Graham Cancer Center, Newark, Delaware, United States

Medical Oncology Hematology Consultants PA, Newark, Delaware, United States

Beebe Health Campus, Rehoboth Beach, Delaware, United States

MedStar Georgetown University Hospital, Washington, District of Columbia, United States

MedStar Washington Hospital Center, Washington, District of Columbia, United States

Morton Plant Hospital, Clearwater, Florida, United States

University of Florida Health Science Center - Gainesville, Gainesville, Florida, United States

Mayo Clinic in Florida, Jacksonville, Florida, United States

Orlando Health Cancer Institute, Orlando, Florida, United States

Memorial Hospital West, Pembroke Pines, Florida, United States

Mease Countryside Hospital, Safety Harbor, Florida, United States

Tallahassee Memorial HealthCare, Tallahassee, Florida, United States

Tampa General Hospital, Tampa, Florida, United States

Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida, United States

Phoebe Putney Memorial Hospital, Albany, Georgia, United States

Grady Health System, Atlanta, Georgia, United States

Emory University Hospital Midtown, Atlanta, Georgia, United States

Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia, United States

Emory Saint Joseph's Hospital, Atlanta, Georgia, United States

Northside Hospital, Atlanta, Georgia, United States

Augusta Oncology Associates PC-D'Antignac, Augusta, Georgia, United States

Augusta Oncology Associates PC-Wheeler, Augusta, Georgia, United States

Northside Hospital - Duluth, Duluth, Georgia, United States

Northside Hospital - Gwinnett, Lawrenceville, Georgia, United States

Hawaii Cancer Care - Westridge, 'Aiea, Hawaii, United States

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu, Hawaii, United States

Queen's Cancer Cenrer - POB I, Honolulu, Hawaii, United States

Queen's Medical Center, Honolulu, Hawaii, United States

Straub Clinic and Hospital, Honolulu, Hawaii, United States

Queen's Cancer Center - Kuakini, Honolulu, Hawaii, United States

Kaiser Permanente Moanalua Medical Center, Honolulu, Hawaii, United States

Kapiolani Medical Center for Women and Children, Honolulu, Hawaii, United States

Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho, United States

Saint Luke's Cancer Institute - Boise, Boise, Idaho, United States

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell, Idaho, United States

Kootenai Health - Coeur d'Alene, Coeur d'Alene, Idaho, United States

Saint Luke's Cancer Institute - Fruitland, Fruitland, Idaho, United States

Saint Luke's Cancer Institute - Meridian, Meridian, Idaho, United States

Saint Luke's Cancer Institute - Nampa, Nampa, Idaho, United States

Saint Alphonsus Cancer Care Center-Nampa, Nampa, Idaho, United States

Kootenai Clinic Cancer Services - Post Falls, Post Falls, Idaho, United States

Kootenai Cancer Clinic, Sandpoint, Idaho, United States

Saint Luke's Cancer Institute - Twin Falls, Twin Falls, Idaho, United States

Advocate Good Shepherd Hospital, Barrington, Illinois, United States

Illinois CancerCare-Bloomington, Bloomington, Illinois, United States

Illinois CancerCare-Canton, Canton, Illinois, United States

Illinois CancerCare-Carthage, Carthage, Illinois, United States

Centralia Oncology Clinic, Centralia, Illinois, United States

Northwestern University, Chicago, Illinois, United States

University of Illinois, Chicago, Illinois, United States

University of Chicago Comprehensive Cancer Center, Chicago, Illinois, United States

Advocate Illinois Masonic Medical Center, Chicago, Illinois, United States

AMG Crystal Lake - Oncology, Crystal Lake, Illinois, United States

Carle at The Riverfront, Danville, Illinois, United States

Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois, United States

Decatur Memorial Hospital, Decatur, Illinois, United States

Illinois CancerCare-Dixon, Dixon, Illinois, United States

Advocate Good Samaritan Hospital, Downers Grove, Illinois, United States

Crossroads Cancer Center, Effingham, Illinois, United States

Advocate Sherman Hospital, Elgin, Illinois, United States

Illinois CancerCare-Eureka, Eureka, Illinois, United States

Illinois CancerCare-Galesburg, Galesburg, Illinois, United States

Ingalls Memorial Hospital, Harvey, Illinois, United States

Advocate South Suburban Hospital, Hazel Crest, Illinois, United States

Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois, United States

AMG Libertyville - Oncology, Libertyville, Illinois, United States

Condell Memorial Hospital, Libertyville, Illinois, United States

Illinois CancerCare-Macomb, Macomb, Illinois, United States

Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois, United States

Trinity Medical Center, Moline, Illinois, United States

UC Comprehensive Cancer Center at Silver Cross, New Lenox, Illinois, United States

Cancer Care Center of O'Fallon, O'Fallon, Illinois, United States

Advocate Christ Medical Center, Oak Lawn, Illinois, United States

University of Chicago Medicine-Orland Park, Orland Park, Illinois, United States

Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois, United States

Advocate Lutheran General Hospital, Park Ridge, Illinois, United States

Illinois CancerCare-Pekin, Pekin, Illinois, United States

Illinois CancerCare-Peoria, Peoria, Illinois, United States

Illinois CancerCare-Peru, Peru, Illinois, United States

Illinois CancerCare-Princeton, Princeton, Illinois, United States

OSF Saint Anthony Medical Center, Rockford, Illinois, United States

SwedishAmerican Regional Cancer Center/ACT, Rockford, Illinois, United States

Southern Illinois University School of Medicine, Springfield, Illinois, United States

Springfield Clinic, Springfield, Illinois, United States

Memorial Medical Center, Springfield, Illinois, United States

Carle Cancer Center, Urbana, Illinois, United States

Illinois CancerCare - Washington, Washington, Illinois, United States

IU Health West Hospital, Avon, Indiana, United States

IU Health North Hospital, Carmel, Indiana, United States

Northwest Cancer Center - Main Campus, Crown Point, Indiana, United States

Northwest Oncology LLC, Dyer, Indiana, United States

Northwest Cancer Center - Hobart, Hobart, Indiana, United States

Saint Mary Medical Center, Hobart, Indiana, United States

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, United States

Sidney and Lois Eskenazi Hospital, Indianapolis, Indiana, United States

Saint Catherine Hospital, Indianapolis, Indiana, United States

The Community Hospital, Munster, Indiana, United States

Women's Diagnostic Center - Munster, Munster, Indiana, United States

Northwest Cancer Center - Valparaiso, Valparaiso, Indiana, United States

Physicians' Clinic of Iowa PC, Cedar Rapids, Iowa, United States

Mercy Hospital, Cedar Rapids, Iowa, United States

Oncology Associates at Mercy Medical Center, Cedar Rapids, Iowa, United States

Heartland Oncology and Hematology LLP, Council Bluffs, Iowa, United States

Methodist Jennie Edmundson Hospital, Council Bluffs, Iowa, United States

University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa, United States

Cancer Center of Kansas - Chanute, Chanute, Kansas, United States

Cancer Center of Kansas - Dodge City, Dodge City, Kansas, United States

Cancer Center of Kansas - El Dorado, El Dorado, Kansas, United States

HaysMed University of Kansas Health System, Hays, Kansas, United States

Cancer Center of Kansas-Independence, Independence, Kansas, United States

University of Kansas Cancer Center, Kansas City, Kansas, United States

Cancer Center of Kansas-Kingman, Kingman, Kansas, United States

Lawrence Memorial Hospital, Lawrence, Kansas, United States

Cancer Center of Kansas-Liberal, Liberal, Kansas, United States

Cancer Center of Kansas - McPherson, McPherson, Kansas, United States

Cancer Center of Kansas - Newton, Newton, Kansas, United States

Olathe Health Cancer Center, Olathe, Kansas, United States

Menorah Medical Center, Overland Park, Kansas, United States

University of Kansas Cancer Center-Overland Park, Overland Park, Kansas, United States

University of Kansas Hospital-Indian Creek Campus, Overland Park, Kansas, United States

Cancer Center of Kansas - Parsons, Parsons, Kansas, United States

Cancer Center of Kansas - Pratt, Pratt, Kansas, United States

Cancer Center of Kansas - Salina, Salina, Kansas, United States

Salina Regional Health Center, Salina, Kansas, United States

University of Kansas Health System Saint Francis Campus, Topeka, Kansas, United States

Cancer Center of Kansas - Wellington, Wellington, Kansas, United States

University of Kansas Hospital-Westwood Cancer Center, Westwood, Kansas, United States

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita, Kansas, United States

Ascension Via Christi Hospitals Wichita, Wichita, Kansas, United States

Cancer Center of Kansas - Wichita, Wichita, Kansas, United States

Cancer Center of Kansas - Winfield, Winfield, Kansas, United States

University of Kentucky/Markey Cancer Center, Lexington, Kentucky, United States

Ochsner Hematology Oncology North Shore - Covington (West Region), Covington, Louisiana, United States

Ochsner Medical Center Jefferson, New Orleans, Louisiana, United States

Anne Arundel Medical Center, Annapolis, Maryland, United States

Walter Reed National Military Medical Center, Bethesda, Maryland, United States

FMH James M Stockman Cancer Institute, Frederick, Maryland, United States

Tufts Medical Center, Boston, Massachusetts, United States

Boston Medical Center, Boston, Massachusetts, United States

Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Saint Joseph Mercy Hospital, Ann Arbor, Michigan, United States

University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States

Bronson Battle Creek, Battle Creek, Michigan, United States

Saint Joseph Mercy Brighton, Brighton, Michigan, United States

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton, Michigan, United States

Saint Joseph Mercy Canton, Canton, Michigan, United States

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton, Michigan, United States

Saint Joseph Mercy Chelsea, Chelsea, Michigan, United States

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea, Michigan, United States

Henry Ford Macomb Hospital-Clinton Township, Clinton Township, Michigan, United States

Henry Ford Hospital, Detroit, Michigan, United States

Genesee Cancer and Blood Disease Treatment Center, Flint, Michigan, United States

Genesee Hematology Oncology PC, Flint, Michigan, United States

Genesys Hurley Cancer Institute, Flint, Michigan, United States

Hurley Medical Center, Flint, Michigan, United States

Spectrum Health at Butterworth Campus, Grand Rapids, Michigan, United States

Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan, United States

Bronson Methodist Hospital, Kalamazoo, Michigan, United States

West Michigan Cancer Center, Kalamazoo, Michigan, United States

Ascension Borgess Cancer Center, Kalamazoo, Michigan, United States

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan, United States

Trinity Health Muskegon Hospital, Muskegon, Michigan, United States

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores, Michigan, United States

Ascension Providence Hospitals - Novi, Novi, Michigan, United States

Saint Joseph Mercy Oakland, Pontiac, Michigan, United States

Corewell Health Reed City Hospital, Reed City, Michigan, United States

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph, Michigan, United States

Lakeland Medical Center Saint Joseph, Saint Joseph, Michigan, United States

Ascension Providence Hospitals - Southfield, Southfield, Michigan, United States

Munson Medical Center, Traverse City, Michigan, United States

University of Michigan Health - West, Wyoming, Michigan, United States

Huron Gastroenterology PC, Ypsilanti, Michigan, United States

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti, Michigan, United States

Sanford Joe Lueken Cancer Center, Bemidji, Minnesota, United States

Minnesota Oncology - Burnsville, Burnsville, Minnesota, United States

Mercy Hospital, Coon Rapids, Minnesota, United States

Fairview Southdale Hospital, Edina, Minnesota, United States

Abbott-Northwestern Hospital, Minneapolis, Minnesota, United States

Hennepin County Medical Center, Minneapolis, Minnesota, United States

Mayo Clinic in Rochester, Rochester, Minnesota, United States

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud, Minnesota, United States

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota, United States

Regions Hospital, Saint Paul, Minnesota, United States

United Hospital, Saint Paul, Minnesota, United States

Baptist Memorial Hospital and Cancer Center-Golden Triangle, Columbus, Mississippi, United States

Baptist Cancer Center-Grenada, Grenada, Mississippi, United States

University of Mississippi Medical Center, Jackson, Mississippi, United States

Baptist Memorial Hospital and Cancer Center-Union County, New Albany, Mississippi, United States

Baptist Memorial Hospital and Cancer Center-Oxford, Oxford, Mississippi, United States

Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven, Mississippi, United States

Saint Francis Medical Center, Cape Girardeau, Missouri, United States

MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia, Missouri, United States

Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri, United States

Parkland Health Center - Farmington, Farmington, Missouri, United States

Centerpoint Medical Center LLC, Independence, Missouri, United States

Truman Medical Centers, Kansas City, Missouri, United States

Saint Luke's Hospital of Kansas City, Kansas City, Missouri, United States

Research Medical Center, Kansas City, Missouri, United States

University of Kansas Cancer Center - North, Kansas City, Missouri, United States

University of Kansas Cancer Center - Lee's Summit, Lee's Summit, Missouri, United States

Saint Luke's East - Lee's Summit, Lee's Summit, Missouri, United States

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City, Missouri, United States

Heartland Regional Medical Center, Saint Joseph, Missouri, United States

Washington University School of Medicine, Saint Louis, Missouri, United States

Siteman Cancer Center-South County, Saint Louis, Missouri, United States

Missouri Baptist Medical Center, Saint Louis, Missouri, United States

Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri, United States

Mercy Hospital Saint Louis, Saint Louis, Missouri, United States

Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri, United States

Sainte Genevieve County Memorial Hospital, Sainte Genevieve, Missouri, United States

Mercy Hospital Springfield, Springfield, Missouri, United States

CoxHealth South Hospital, Springfield, Missouri, United States

Missouri Baptist Sullivan Hospital, Sullivan, Missouri, United States

BJC Outpatient Center at Sunset Hills, Sunset Hills, Missouri, United States

Community Hospital of Anaconda, Anaconda, Montana, United States

Billings Clinic Cancer Center, Billings, Montana, United States

Bozeman Deaconess Hospital, Bozeman, Montana, United States

Benefis Healthcare- Sletten Cancer Institute, Great Falls, Montana, United States

Community Medical Hospital, Missoula, Montana, United States

Nebraska Medicine-Bellevue, Bellevue, Nebraska, United States

Nebraska Cancer Specialists/Oncology Hematology West PC - MECC, Omaha, Nebraska, United States

Nebraska Methodist Hospital, Omaha, Nebraska, United States

Oncology Associates PC, Omaha, Nebraska, United States

Nebraska Medicine-Village Pointe, Omaha, Nebraska, United States

University of Nebraska Medical Center, Omaha, Nebraska, United States

OptumCare Cancer Care at Seven Hills, Henderson, Nevada, United States

OptumCare Cancer Care at Charleston, Las Vegas, Nevada, United States

OptumCare Cancer Care at Fort Apache, Las Vegas, Nevada, United States

New Hampshire Oncology Hematology PA-Concord, Concord, New Hampshire, United States

Solinsky Center for Cancer Care, Manchester, New Hampshire, United States

Englewood Hospital and Medical Center, Englewood, New Jersey, United States

Hackensack University Medical Center, Hackensack, New Jersey, United States

Inspira Medical Center Mullica Hill, Mullica Hill, New Jersey, United States

University of New Mexico Cancer Center, Albuquerque, New Mexico, United States

Presbyterian Kaseman Hospital, Albuquerque, New Mexico, United States

Presbyterian Rust Medical Center/Jorgensen Cancer Center, Rio Rancho, New Mexico, United States

Roswell Park Cancer Institute, Buffalo, New York, United States

Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse, New York, United States

NYU Winthrop Hospital, Mineola, New York, United States

Mount Sinai Chelsea, New York, New York, United States

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York, United States

Mount Sinai West, New York, New York, United States

Mount Sinai Hospital, New York, New York, United States

Vassar Brothers Medical Center, Poughkeepsie, New York, United States

Pluta Cancer Center, Rochester, New York, United States

University of Rochester, Rochester, New York, United States

Stony Brook University Medical Center, Stony Brook, New York, United States

Wilmot Cancer Institute at Webster, Webster, New York, United States

Randolph Health Cancer Center, Asheboro, North Carolina, United States

Cone Health Cancer Center at Alamance Regional, Burlington, North Carolina, United States

Rex Hematology Oncology Associates-Cary, Cary, North Carolina, United States

UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, United States

Novant Health Presbyterian Medical Center, Charlotte, North Carolina, United States

Rex Hematology Oncology Associates-Garner, Garner, North Carolina, United States

Cone Health Cancer Center, Greensboro, North Carolina, United States

Cone Health Cancer Center at Drawbridge Parkway, Greensboro, North Carolina, United States

East Carolina University, Greenville, North Carolina, United States

Margaret R Pardee Memorial Hospital, Hendersonville, North Carolina, United States

Novant Health Cancer Institute - Huntersville, Huntersville, North Carolina, United States

Novant Health Presbyterian Medical Center Huntersville, Huntersville, North Carolina, United States

Novant Health Cancer Institute - Kernersville, Kernersville, North Carolina, United States

Novant Health Cancer Institute - Matthews, Matthews, North Carolina, United States

Novant Health Cancer Institute - Mooresville, Mooresville, North Carolina, United States

Novant Health Cancer Institute - Mount Airy, Mount Airy, North Carolina, United States

FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst, North Carolina, United States

UNC Rex Healthcare, Raleigh, North Carolina, United States

UNC Rex Cancer Center of Wakefield, Raleigh, North Carolina, United States

Annie Penn Memorial Hospital, Reidsville, North Carolina, United States

Novant Health Cancer Institute - Rowan, Salisbury, North Carolina, United States

Rowan Regional Medical Center, Salisbury, North Carolina, United States

Novant Health Cancer Institute - Thomasville, Thomasville, North Carolina, United States

Marion L Shepard Cancer Center at Vidant Beaufort Hospital, Washington, North Carolina, United States

Novant Health Forsyth Medical Center, Winston-Salem, North Carolina, United States

Sanford Bismarck Medical Center, Bismarck, North Dakota, United States

Sanford Broadway Medical Center, Fargo, North Dakota, United States

Sanford Roger Maris Cancer Center, Fargo, North Dakota, United States

Summa Health System - Akron Campus, Akron, Ohio, United States

Summa Health System - Barberton Campus, Barberton, Ohio, United States

Strecker Cancer Center-Belpre, Belpre, Ohio, United States

Miami Valley Hospital South, Centerville, Ohio, United States

Adena Regional Medical Center, Chillicothe, Ohio, United States

Good Samaritan Hospital - Cincinnati, Cincinnati, Ohio, United States

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Mount Carmel East Hospital, Columbus, Ohio, United States

The Mark H Zangmeister Center, Columbus, Ohio, United States

Dayton Blood and Cancer Center, Dayton, Ohio, United States

Dayton Physician LLC-Miami Valley Hospital North, Dayton, Ohio, United States

Miami Valley Hospital North, Dayton, Ohio, United States

Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio, United States

Mount Carmel Grove City Hospital, Grove City, Ohio, United States

Kettering Medical Center, Kettering, Ohio, United States

Fairfield Medical Center, Lancaster, Ohio, United States

Memorial Hospital, Marysville, Ohio, United States

Summa Health Medina Medical Center, Medina, Ohio, United States

Licking Memorial Hospital, Newark, Ohio, United States

Mercy Health Perrysburg Cancer Center, Perrysburg, Ohio, United States

Southern Ohio Medical Center, Portsmouth, Ohio, United States

Springfield Regional Cancer Center, Springfield, Ohio, United States

ProMedica Flower Hospital, Sylvania, Ohio, United States

Mercy Health - Saint Anne Hospital, Toledo, Ohio, United States

Toledo Clinic Cancer Centers-Toledo, Toledo, Ohio, United States

Upper Valley Medical Center, Troy, Ohio, United States

Saint Ann's Hospital, Westerville, Ohio, United States

Genesis Healthcare System Cancer Care Center, Zanesville, Ohio, United States

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States

Mercy Hospital Oklahoma City, Oklahoma City, Oklahoma, United States

Clackamas Radiation Oncology Center, Clackamas, Oregon, United States

Providence Cancer Institute Clackamas Clinic, Clackamas, Oregon, United States

Legacy Mount Hood Medical Center, Gresham, Oregon, United States

Providence Newberg Medical Center, Newberg, Oregon, United States

Saint Alphonsus Medical Center-Ontario, Ontario, Oregon, United States

Providence Willamette Falls Medical Center, Oregon City, Oregon, United States

Legacy Good Samaritan Hospital and Medical Center, Portland, Oregon, United States

Providence Portland Medical Center, Portland, Oregon, United States

Providence Saint Vincent Medical Center, Portland, Oregon, United States

Kaiser Permanente Northwest, Portland, Oregon, United States

Legacy Meridian Park Hospital, Tualatin, Oregon, United States

Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania, United States

Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania, United States

Geisinger Medical Center, Danville, Pennsylvania, United States

Pocono Medical Center, East Stroudsburg, Pennsylvania, United States

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States

Guthrie Medical Group PC-Robert Packer Hospital, Sayre, Pennsylvania, United States

Community Medical Center, Scranton, Pennsylvania, United States

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre, Pennsylvania, United States

Asplundh Cancer Pavilion, Willow Grove, Pennsylvania, United States

Rhode Island Hospital, Providence, Rhode Island, United States

Women and Infants Hospital, Providence, Rhode Island, United States

Smilow Cancer Hospital Care Center - Westerly, Westerly, Rhode Island, United States

Tidelands Georgetown Memorial Hospital, Georgetown, South Carolina, United States

Saint Francis Hospital, Greenville, South Carolina, United States

Saint Francis Cancer Center, Greenville, South Carolina, United States

Self Regional Healthcare, Greenwood, South Carolina, United States

Lexington Medical Center, West Columbia, South Carolina, United States

Avera Cancer Institute-Aberdeen, Aberdeen, South Dakota, United States

Avera Cancer Institute at Pierre, Pierre, South Dakota, United States

Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota, United States

Avera Cancer Institute, Sioux Falls, South Dakota, United States

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota, United States

Baptist Memorial Hospital and Cancer Center-Collierville, Collierville, Tennessee, United States

University of Tennessee - Knoxville, Knoxville, Tennessee, United States

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis, Tennessee, United States

Houston Methodist San Jacinto Hospital, Baytown, Texas, United States

MD Anderson in The Woodlands, Conroe, Texas, United States

Parkland Memorial Hospital, Dallas, Texas, United States

UT Southwestern Simmons Cancer Center - RedBird, Dallas, Texas, United States

UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas, United States

Tarrant County Hospital District/JPS Health Network, Fort Worth, Texas, United States

UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth, Texas, United States

Houston Methodist Hospital, Houston, Texas, United States

M D Anderson Cancer Center, Houston, Texas, United States

Methodist Willowbrook Hospital, Houston, Texas, United States

MD Anderson West Houston, Houston, Texas, United States

Houston Methodist West Hospital, Houston, Texas, United States

MD Anderson League City, League City, Texas, United States

Houston Methodist Saint John Hospital, Nassau Bay, Texas, United States

UT Southwestern Clinical Center at Richardson/Plano, Richardson, Texas, United States

MD Anderson in Sugar Land, Sugar Land, Texas, United States

Houston Methodist Sugar Land Hospital, Sugar Land, Texas, United States

Houston Methodist The Woodlands Hospital, The Woodlands, Texas, United States

Inova Schar Cancer Institute, Fairfax, Virginia, United States

Inova Fair Oaks Hospital, Fairfax, Virginia, United States

Inova Fairfax Hospital, Falls Church, Virginia, United States

Bon Secours Memorial Regional Medical Center, Mechanicsville, Virginia, United States

Bon Secours Saint Francis Medical Center, Midlothian, Virginia, United States

Bon Secours Saint Mary's Hospital, Richmond, Virginia, United States

VCU Massey Cancer Center at Stony Point, Richmond, Virginia, United States

Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia, United States

Valley Medical Center, Renton, Washington, United States

Legacy Cancer Institute Medical Oncology and Day Treatment, Vancouver, Washington, United States

Legacy Salmon Creek Hospital, Vancouver, Washington, United States

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima, Washington, United States

Edwards Comprehensive Cancer Center, Huntington, West Virginia, United States

Langlade Hospital and Cancer Center, Antigo, Wisconsin, United States

ThedaCare Regional Cancer Center, Appleton, Wisconsin, United States

ThedaCare Cancer Care - Berlin, Berlin, Wisconsin, United States

Aurora Cancer Care-Southern Lakes VLCC, Burlington, Wisconsin, United States

Aurora Health Care Germantown Health Center, Germantown, Wisconsin, United States

Aurora Cancer Care-Grafton, Grafton, Wisconsin, United States

Aurora BayCare Medical Center, Green Bay, Wisconsin, United States

Mercyhealth Hospital and Cancer Center - Janesville, Janesville, Wisconsin, United States

UW Cancer Center Johnson Creek, Johnson Creek, Wisconsin, United States

Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin, United States

University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States

Aurora Bay Area Medical Group-Marinette, Marinette, Wisconsin, United States

Aspirus Medford Hospital, Medford, Wisconsin, United States

Froedtert Menomonee Falls Hospital, Menomonee Falls, Wisconsin, United States

Aurora Cancer Care-Milwaukee, Milwaukee, Wisconsin, United States

Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin, United States

Medical College of Wisconsin, Milwaukee, Wisconsin, United States

Aurora Sinai Medical Center, Milwaukee, Wisconsin, United States

ProHealth D N Greenwald Center, Mukwonago, Wisconsin, United States

ThedaCare Regional Medical Center - Neenah, Neenah, Wisconsin, United States

ThedaCare Cancer Care - New London, New London, Wisconsin, United States

Drexel Town Square Health Center, Oak Creek, Wisconsin, United States

ProHealth Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin, United States

ThedaCare Cancer Care - Oshkosh, Oshkosh, Wisconsin, United States

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin, United States

Aurora Cancer Care-Racine, Racine, Wisconsin, United States

Ascension Saint Mary's Hospital, Rhinelander, Wisconsin, United States

ThedaCare Cancer Care - Shawano, Shawano, Wisconsin, United States

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan, Wisconsin, United States

Ascension Saint Michael's Hospital, Stevens Point, Wisconsin, United States

Aurora Medical Center in Summit, Summit, Wisconsin, United States

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers, Wisconsin, United States

UW Cancer Center at ProHealth Care, Waukesha, Wisconsin, United States

ThedaCare Cancer Care - Waupaca, Waupaca, Wisconsin, United States

Aspirus Regional Cancer Center, Wausau, Wisconsin, United States

Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin, United States

Aurora West Allis Medical Center, West Allis, Wisconsin, United States

Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend, Wisconsin, United States

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin, United States

Doctors Cancer Center, Manati, , Puerto Rico

Centro Comprensivo de Cancer de UPR, San Juan, , Puerto Rico

PROncology, San Juan, , Puerto Rico

San Juan City Hospital, San Juan, , Puerto Rico

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

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