Spots Global Cancer Trial Database for More Complete Removal of Malignant Brain Tumors by Fluorescence-Guided Surgery

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Trial Identification

Brief Title: More Complete Removal of Malignant Brain Tumors by Fluorescence-Guided Surgery

Official Title: A Multicenter Phase II Study of 5-Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Newly Diagnosed or Recurrent Malignant Gliomas

Study ID: NCT01445691

Conditions

Benign Neoplasms, Brain

Brain Cancer

Brain Neoplasms, Benign

Brain Neoplasms, Malignant

Brain Tumor, Primary

Brain Tumor, Recurrent

Brain Tumors

Intracranial Neoplasms

Neoplasms, Brain

Neoplasms, Intracranial

Primary Brain Neoplasms

Primary Malignant Brain Neoplasms

Primary Malignant Brain Tumors

Gliomas

Glioblastoma

Interventions

5-ALA (Gliolan)

Study Description

Brief Summary: The purpose of this study is to determine the safety and utility of 5-aminolevulinic acid (ALA) for identifying your tumor during surgery. 5-ALA is not FDA approved at this time. When the investigators remove the tumor from your brain, it is important that they remove all of the tumor and not remove parts of normal brain. Sometimes this can be difficult because the tumor can look like normal brain. In some brain tumors, 5-ALA can make the tumors glow red under blue light. This may make it easier for your doctor to take out all of the tumor from your brain. The purpose of this study is to: * Make sure that 5-ALA helps the doctor remove more of the tumor. * Make sure 5-ALA does not cause any side effects. If you do not want to participate in this study, your doctor(s) will still do their best to remove all of the tumor in your brain. Whether or not you join this study will not change your treatment for your brain tumor.

Detailed Description: