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Spots Global Cancer Trial Database for A Phase I Study of ABT-888 in Combination With Conventional Whole Brain Radiation Therapy (WBRT) in Cancer Patients With Brain Metastases

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Trial Identification

Brief Title: A Phase I Study of ABT-888 in Combination With Conventional Whole Brain Radiation Therapy (WBRT) in Cancer Patients With Brain Metastases

Official Title: A Phase 1 Study Evaluating the Safety, Tolerability and Pharmacokinetics of ABT-888 in Combination With Whole Brain Radiation Therapy in Subjects With Brain Metastases

Study ID: NCT00649207

Study Description

Brief Summary: This Phase I clinical trial is studying the side effects and best dose of ABT-888 when given together with Whole Brain Radiation Therapy (WBRT) in treating patients with brain metastases.

Detailed Description: This is a Phase 1, multicenter, dose-escalation study evaluating the safety, tolerability and pharmacokinetics of the PARP inhibitor ABT-888 in combination with conventional whole brain radiation therapy (WBRT) in the treatment of subjects with solid tumors metastatic to the brain.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Site Reference ID/Investigator# 8334, Atlanta, Georgia, United States

Site Reference ID/Investigator# 52462, Chicago, Illinois, United States

Site Reference ID/Investigator# 24483, Kansas City, Kansas, United States

Site Reference ID/Investigator# 7180, Baltimore, Maryland, United States

Site Reference ID/Investigator# 19021, Detroit, Michigan, United States

Site Reference ID/Investigator# 6344, Philadelphia, Pennsylvania, United States

Site Reference ID/Investigator# 6653, Madison, Wisconsin, United States

Site Reference ID/Investigator# 18542, Toronto, , Canada

Site Reference ID/Investigator# 46322, Ponce, , Puerto Rico

Contact Details

Name: Shepherd L Stacie, MD

Affiliation: AbbVie

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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