Spots Global Cancer Trial Database for Local Ablative Therapy for Patients With Multiple (4-10) Brain Metastases

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Trial Identification

Brief Title: Local Ablative Therapy for Patients With Multiple (4-10) Brain Metastases

Official Title: Local Ablative Therapy for Patients With Multiple (4-10) Brain Metastases

Study ID: NCT04397978

Conditions

Brain Metastases, Adult

Interventions

Stereotactic radiotherapy

Study Description

Brief Summary: To observe the quality of life (QOL) and to report on toxicity and outcome parameters after the (repeated) use of local ablative therapy (LAT) i.e. stereotactic radiotherapy (SRT) for patients with multiple (4-10) brain metastases

Detailed Description: Phase IV prospective non-randomized observational trial (registry trial) for patients with a DS-GPA \> 1.5 or an estimated life expectancy of \>3 months and an established diagnosis on dedicated brain MRI of 4-10 BM of any solid primary tumor. We plan to deliver a local ablative therapy (LAT) i.e. SRT in 1 to 5 fractions on visible BM and post-surgical cavities if applicable. Our primary aim is to provide quality of life (QOL) data and our secondary aim is to report on several toxicity and outcome parameters for this patient cohort.