Spots Global Cancer Trial Database for Simvastatin Effect on Radiation Therapy of Brain Metastases
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Trial Identification
Brief Title: Simvastatin Effect on Radiation Therapy of Brain Metastases
Official Title: The Effect of Simvastatin on the Clinical Outcome of Patients With Brain Metastases Treated With Radiation Therapy: a Pilot Study
Study ID: NCT02104193
Conditions
Study Description
Brief Summary: The purpose of the study is to evaluate the effect of simvastatin in combination with radiotherapy on the clinical outcomes of patients with brain metastases.
Detailed Description: Despite current advances in therapies, the outcome for patients with brain metastases is fatal. New therapeutic approaches, such as radiosensitizing agents, are needed to provide a significant survival advantage for those patients. Statins have been reported to enhance the efficacy of radiotherapy in addition to a neuroprotective effect. The aim of the study is to evaluate the effect of simvastatin on the efficacy and safety of radiation therapy in patients with brain metastases and on improving patients' quality of life.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Ain Shams university Hospitals, Cairo, , Egypt
Contact Details
Name: May A Shawki, master
Affiliation: Faculty of Pharmacy- Ain Shams university
Role: PRINCIPAL_INVESTIGATOR
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