Spots Global Cancer Trial Database for Molecularly Targeted Umbrella Study in Luminal Advanced Breast Cancer
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Trial Identification
Brief Title: Molecularly Targeted Umbrella Study in Luminal Advanced Breast Cancer
Official Title: Precision Treatment of Luminal Advanced Breast Cancer Based on Molecular Subtyping
Study ID: NCT04355858
Study Description
Brief Summary: This study is a prospective, single-center, open-label, umbrella-shaped phase II clinical study for patients with HR+/HER2- endocrine-resistant advanced breast cancer.
Detailed Description: Seven precision treatment cohorts, which targeting NF1 mutation, gBRCA mutation,HER2 mutation, FDGFRb mutation PAM pathway mutations, CD8 and AR, as long as an epigenetic therapy cohort and a combined immunization cohort were initially set up based on gene expression profiles and molecular pathways. The main purpose is to screen valuable treatment cohorts and prepare for subsequent randomized controlled phase III clinical studies with larger sample size.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
Cancer Hospital Affiliated to Fudan University, Shanghai, Shanghai, China
Contact Details
Name: Zhi-Ming Shao
Affiliation: Fudan University
Role: PRINCIPAL_INVESTIGATOR
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