Spots Global Cancer Trial Database for Immunoscore in Rectal Cancer

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Trial Identification

Brief Title: Immunoscore in Rectal Cancer

Official Title: A Study to Determine the Immunopheotype of Locally Advanced Rectal Adenocarcinoma and Its Correlation With the Efficacy of Neoadjuvant Chemoradiotherapy

Study ID: NCT02017509

Conditions

Rectal Adenocarcinoma

Interventions

Diagnostic Biopsy and Surgical Procedure

Intravoxel incoherent motion MRI (IVIM)

Dynamic Contrast Enhanced MRI (DCE-MRI)

RNA gene expression analysis

Study Description

Brief Summary: This is an observational study of tumor samples and MRI imaging in patients with colorectal cancers. A tumor sample, MRI scans, and treatment outcome data will be used for research purposes to see if it is possible to predict patients' response to treatment.

Detailed Description: The quality of the immune environment in colorectal cancer biopsy samples correlates with disease-free survival and overall survival more so than current staging conventions. This study will use a scoring system called 'immunoscore' to characterize the immune enviroment. Researchers hypothesize that the immunoscore will correlate with outcomes of colorectal patients treated with neoadjuvant chemoradiation.