Spots Global Cancer Trial Database for rectal adenocarcinoma

Every month we try and update this database with for rectal adenocarcinoma cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Proteomic Approach Using Matrix-assisted Laser Desorption/Ionization Tandem Time-of-flight (MALDI-TOF/TOF) of Tumor Response in Rectal Carcinoma After Radiochemotherapy	NCT00855946	Rectal Adenocar...		18 Years - 80 Years	University Hospital, Bordeaux
Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer	NCT04703101	Locally Advance... Rectal Adenocar... Stage II Rectal... Stage IIA Recta... Stage IIB Recta... Stage IIC Recta... Stage III Recta... Stage IIIA Rect... Stage IIIB Rect... Stage IIIC Rect...	Capecitabine Fluorouracil Intensity-Modul... Leucovorin Oxaliplatin Quality-of-Life... Surveillance Total Mesorecta...	18 Years -	Jonsson Comprehensive Cancer Center
Prospective Validation Study for the Proprietary Rectal and Anal Cancer Protein Expression Assays	NCT02407561	Rectal Adenocar... Anal Adenocarci... Anal Squamous C...		18 Years -	Castle Biosciences Incorporated
Capecitabine and Lenvatinib With External Radiation in Rectal Adenocarcinoma	NCT02935309	Rectal Cancer Rectal Adenocar...	Lenvatinib Capecitabine External Radiat...	18 Years -	H. Lee Moffitt Cancer Center and Research Institute
Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy Treatment (Capecitabine) During Radiation Therapy for Rectal Cancer	NCT04406857	Locally Advance... Rectal Adenocar... Stage II Rectal... Stage III Recta...	Capecitabine Radiation Thera... Ropidoxuridine	18 Years -	National Cancer Institute (NCI)
Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer	NCT04963283	Colorectal Aden... Colon Cancer Colon Adenocarc... Rectum Cancer Rectal Cancer Rectal Adenocar... Colorectal Canc...	Cabozantinib Nivolumab	18 Years -	University of Colorado, Denver
The Safety and Feasibility of MONOFIX on Fascial Closure of Mid-line Wound After Minimally Invasive Colorectal Cancer Surgery	NCT05872334	Colon Cancer Rectal Cancer Colon Adenocarc... Rectal Adenocar...	Monofix	18 Years - 80 Years	Samsung Medical Center
Evaluation of Rectal Tumor Margin Using Confocal Endomicroscopy and Comparison to Histopathology	NCT01887509	Rectal Cancer Rectal Adenocar...	Probe-based con... Rectoscopy EUS Biopsy and rese...	18 Years -	IHU Strasbourg
Talimogene Laherparepvec, Chemotherapy, and Radiation Therapy Before Surgery in Treating Patients With Locally Advanced or Metastatic Rectal Cancer	NCT03300544	Locally Advance... Metastatic Rect... Rectal Adenocar... Stage III Recta... Stage IIIA Rect... Stage IIIB Rect... Stage IIIC Rect... Stage IV Rectal... Stage IVA Recta... Stage IVB Recta...	Capecitabine Fluorouracil Leucovorin Oxaliplatin Radiation Thera... Talimogene Lahe...	18 Years -	National Cancer Institute (NCI)
S1613, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery	NCT03365882	Colon Adenocarc... ERBB2 Gene Ampl... Rectal Adenocar... Recurrent Colon... Recurrent Recta... Stage III Colon... Stage III Recta... Stage IIIA Colo... Stage IIIA Rect... Stage IIIB Colo... Stage IIIB Rect... Stage IIIC Colo... Stage IIIC Rect... Stage IV Colon ... Stage IV Rectal... Stage IVA Colon... Stage IVA Recta... Stage IVB Colon... Stage IVB Recta...	Cetuximab Irinotecan Hydr... Laboratory Biom... Pertuzumab Trastuzumab HER-2 testing	18 Years -	SWOG Cancer Research Network
Role of Neoadjuvent Radiotherapy in Locally Advanced Cancer Rectum	NCT04814784	Rectal Adenocar...	Neoadjuvent rad...	18 Years - 70 Years	Assiut University
Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy Treatment (Capecitabine) During Radiation Therapy for Rectal Cancer	NCT04406857	Locally Advance... Rectal Adenocar... Stage II Rectal... Stage III Recta...	Capecitabine Radiation Thera... Ropidoxuridine	18 Years -	National Cancer Institute (NCI)
Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors	NCT04165772	Rectal Adenocar... Clinical Stage:... Stage III (Any ... Solid Tumor Solid Tumor, Ad...	TSR-042 or Dost... capecitabine or... Intensity Modul...	18 Years -	Memorial Sloan Kettering Cancer Center
Lower or Standard Dose Regorafenib in Treating Patients With Refractory Metastatic Colorectal Cancer	NCT02368886	Colon Adenocarc... Rectal Adenocar... Stage III Color... Stage IIIA Colo... Stage IIIB Colo... Stage IIIC Colo... Stage IV Colore... Stage IVA Color... Stage IVB Color...	Clobetasol Prop... Pharmacological... Quality-of-Life... Regorafenib	18 Years -	Academic and Community Cancer Research United
Prospective Validation Study for the Proprietary Rectal and Anal Cancer Protein Expression Assays	NCT02407561	Rectal Adenocar... Anal Adenocarci... Anal Squamous C...		18 Years -	Castle Biosciences Incorporated
TAS-102 With Concurrent Radiation for the Treatment of Untreated Resectable Stage II-III Rectal Cancer	NCT04104139	Rectal Adenocar... Stage IIA Recta... Stage IIB Recta... Stage III Recta... Stage IIIA Rect... Stage IIIB Rect... Stage IIIC Rect...	3-Dimensional C... Intensity-Modul... Trifluridine an...	18 Years -	OHSU Knight Cancer Institute
A Trial of Durvalumab (MEDI 4736) in Combination With Extended Neoadjuvant Regimens in Rectal Cancer	NCT04621370	Rectal Cancer Rectal Adenocar... Rectal Neoplasm...	Durvalumab FOLFOX Short Course Ra... Long course che... Capecitabine	18 Years -	Cancer Research UK, Glasgow
Evaluation of Quality of Life and Utilities Following Surgical Treatment of Stage I-IV Rectal Cancer	NCT02107105	Rectal Adenocar... Stage I Rectal ... Stage II Rectal... Stage IIA Recta... Stage IIB Recta... Stage IIC Recta... Stage III Recta... Stage IIIA Rect... Stage IIIB Rect... Stage IIIC Rect... Stage IV Rectal... Stage IVA Recta... Stage IVB Recta... Stage IVC Recta...	Quality-of-Life... Questionnaire A...	18 Years -	M.D. Anderson Cancer Center
Factors Predicting Recurrence in Rectal Cancer After Surgery	NCT03899870	Rectal Cancer Rectal Adenocar...	Rectal resectio... Neoadjuvant the... Adjuvant therap...	-	Université de Sousse
MRI-Guided Adaptive Radiation Therapy for Organ Preservation in Rectal Cancer	NCT04808323	Rectal Adenocar...	Capecitabine Initial Dose of... Cohort A: Dose ... Cohort B: Dose ... Cohort C: Dose ... FOLFOX	18 Years -	Medical College of Wisconsin
Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer	NCT04703101	Locally Advance... Rectal Adenocar... Stage II Rectal... Stage IIA Recta... Stage IIB Recta... Stage IIC Recta... Stage III Recta... Stage IIIA Rect... Stage IIIB Rect... Stage IIIC Rect...	Capecitabine Fluorouracil Intensity-Modul... Leucovorin Oxaliplatin Quality-of-Life... Surveillance Total Mesorecta...	18 Years -	Jonsson Comprehensive Cancer Center
Audit of Surgery for Colorectal Cancer	NCT04349384	Rectal Adenocar... Colon Adenocarc...	Colorectal rese...	18 Years -	Institut National d'Oncologie, Morocco
Prospective Pilot Study of Multimodal Radiological Evaluation Feasibility During Chemoradiotherapy of Rectal Adenocarcinomas	NCT01619696	Rectal Adenocar...	Pelvic MRI and ...	18 Years - 80 Years	University Hospital, Toulouse
Adaptive Radiation for Locally Advanced Rectal Adenocarcinoma	NCT05108428	Rectal Adenocar...	Capecitabine Radiation Thera... FOLFOX regimen	18 Years -	H. Lee Moffitt Cancer Center and Research Institute
Predicting the Efficacy and Prognosis of Rectal Cancer Patients Based on ctDNA-MRD Technology	NCT05969938	Rectal Adenocar... Circulating Tum... Minimal Residua... Neoadjuvant Che...	MRD detection	18 Years - 75 Years	Sun Yat-sen University
Bevacizumab, Radiation Therapy, and Combination Chemotherapy in Treating Patients Who Are Undergoing Surgery for Locally Advanced Nonmetastatic Rectal Cancer	NCT00321685	Rectal Adenocar... Stage II Rectal... Stage III Recta...	Bevacizumab Capecitabine Fluorouracil Leucovorin Calc... Oxaliplatin Radiation Thera... Therapeutic Con...	18 Years -	National Cancer Institute (NCI)
Selinexor Combined With Standard Chemoradiation as Neoadjuvant Treatment in Locally Advanced Rectal Cancer	NCT02137356	Rectal Neoplasm...	standard dose p... standard dose c... dose-escalated ...	18 Years -	Sheba Medical Center
Neo-adjuvant Chemoradiotherapy Using Infusional Gemcitabine Followed by Surgery for Locally Advanced Rectal Cancer	NCT02919878	Rectal Adenocar...	Gemcitabine XRT capecitabine	18 Years - 85 Years	King Faisal Specialist Hospital & Research Center
Avoiding Surgery in Rectal Cancer After Pre-Operative Therapy	NCT01047969	Rectal Adenocar...	Adjuvant Chemot... Surgery	18 Years -	Royal Marsden NHS Foundation Trust
The Efficacy and Safety of Short-course Radiation Combined With Adebrelimab and CAPEOX Neo-adjuvant Therapy for Organ-retention in Patients With MSS/pMMR Ultra Low Rectal Adenocarcinoma	NCT06266832	Rectal Adenocar...	Adebrelimab Oxaliplatin Capecitabine Short-course Ra... Biopsy	18 Years -	Sir Run Run Shaw Hospital
ExIST Study of LY2157299 (Galunisertib) in Rectal Cancer	NCT02688712	Rectal Adenocar...	LY2157299 Capecitabine Fluorouracil Tumor specific ...	18 Years -	Providence Health & Services
Peptide-based Immunization for Colon- and and Pancreas-carcinoma	NCT03871790	Colon Neoplasm Colon Adenocarc... Colon Cancer Colo-rectal Can... Rectal Cancer Rectal Neoplasm... Rectal Adenocar... Rectal Tumors Pancreatic Canc... Pancreas Cancer Pancreatic Neop... Pancreatic Aden...		18 Years -	CENTOGENE GmbH Rostock
TAS-102 With Concurrent Radiation for the Treatment of Untreated Resectable Stage II-III Rectal Cancer	NCT04104139	Rectal Adenocar... Stage IIA Recta... Stage IIB Recta... Stage III Recta... Stage IIIA Rect... Stage IIIB Rect... Stage IIIC Rect...	3-Dimensional C... Intensity-Modul... Trifluridine an...	18 Years -	OHSU Knight Cancer Institute
Nordic ORgan Preservation Pilot Approach Nonrandomised Single-Arm Trial for Non-Operative Management of Rectal Cancer	NCT06328361	Rectal Cancer Rectal Adenocar...	Nonoperative su...	18 Years -	Tampere University Hospital
Proteomic Approach Using Matrix-assisted Laser Desorption/Ionization Tandem Time-of-flight (MALDI-TOF/TOF) of Tumor Response in Rectal Carcinoma After Radiochemotherapy	NCT00855946	Rectal Adenocar...		18 Years - 80 Years	University Hospital, Bordeaux
Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors	NCT04165772	Rectal Adenocar... Clinical Stage:... Stage III (Any ... Solid Tumor Solid Tumor, Ad...	TSR-042 or Dost... capecitabine or... Intensity Modul...	18 Years -	Memorial Sloan Kettering Cancer Center
Young-Onset Colorectal Cancer	NCT02863107	Colon Adenocarc... Colorectal Carc... Rectal Adenocar...	Biospecimen Col... Medical Chart R... Quality-of-Life... Questionnaire A...	18 Years - 80 Years	M.D. Anderson Cancer Center
Interest of Saline MR Peritoneography for Pre-operative Assessment of Rectal Cancer	NCT01497457	Rectal Adenocar...	MR saline perit...	18 Years -	Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Pan FGFR Kinase Inhibitor BGJ398 and Combination Chemotherapy in Treating Patients With Untreated Metastatic Pancreatic Cancer	NCT02575508	Colon Adenocarc... Metastatic Panc... Pancreatic Aden... Pancreatic Duct... Rectal Adenocar... Stage III Pancr... Stage IIIA Colo... Stage IIIA Rect... Stage IIIB Colo... Stage IIIB Rect... Stage IIIC Colo... Stage IIIC Rect... Stage IV Pancre... Stage IVA Colon... Stage IVA Recta... Stage IVB Colon... Stage IVB Recta...	Fluorouracil Irinotecan Hydr... Laboratory Biom... Oxaliplatin pan FGFR Kinase... Pharmacological...	18 Years -	Roswell Park Cancer Institute
Pelvic Radiotherapy With Concurrent Neoadjuvant FOLFOX for Patients With Newly Diagnosed Rectal Adenocarcinoma	NCT02319304	Rectal Adenocar...	FOLFOX {5-fluor... Low dose fracti...	18 Years -	University of Maryland, Baltimore
Pelvic Radiotherapy With Concurrent Neoadjuvant FOLFOX for Patients With Newly Diagnosed Rectal Adenocarcinoma	NCT02319304	Rectal Adenocar...	FOLFOX {5-fluor... Low dose fracti...	18 Years -	University of Maryland, Baltimore
Regorafenib in Reducing Recurrence in Patients With Non-metastatic Rectal Cancer Who Have Completed Curative-Intent Treatment	NCT02287727	Rectal Adenocar... Stage IIA Recta... Stage IIB Recta... Stage IIC Recta... Stage IIIA Rect... Stage IIIB Rect...	Laboratory Biom... Regorafenib	18 Years -	Roswell Park Cancer Institute
Immunoscore in Rectal Cancer	NCT02017509	Cancer of the R... Neoplasms, Rect... Rectal Cancer Rectal Tumors Rectal Adenocar...	Diagnostic Biop... Intravoxel inco... Dynamic Contras... RNA gene expres...	18 Years -	Providence Health & Services
Lower or Standard Dose Regorafenib in Treating Patients With Refractory Metastatic Colorectal Cancer	NCT02368886	Colon Adenocarc... Rectal Adenocar... Stage III Color... Stage IIIA Colo... Stage IIIB Colo... Stage IIIC Colo... Stage IV Colore... Stage IVA Color... Stage IVB Color...	Clobetasol Prop... Pharmacological... Quality-of-Life... Regorafenib	18 Years -	Academic and Community Cancer Research United
Chemo-radiotherapy as Main Treatment Strategy for Rectal Cancer. Can we Provide a More Precise and Effective Treatment	NCT03619668	Rectal Cancer Rectal Adenocar... Locally Advance...		18 Years -	Aalborg University Hospital
Audit of Surgery for Colorectal Cancer	NCT04349384	Rectal Adenocar... Colon Adenocarc...	Colorectal rese...	18 Years -	Institut National d'Oncologie, Morocco
Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer	NCT02921256	Rectal Adenocar... Stage II Rectal... Stage III Recta...	Capecitabine Fluorouracil Intensity-Modul... Leucovorin Oxaliplatin Pembrolizumab Veliparib	18 Years -	National Cancer Institute (NCI)
Avoiding Surgery in Rectal Cancer After Pre-Operative Therapy	NCT01047969	Rectal Adenocar...	Adjuvant Chemot... Surgery	18 Years -	Royal Marsden NHS Foundation Trust
Assessing the Additional Neoplasia Yield of Computer-aided Colonoscopy in a Screening Setting	NCT04441580	Colonic Neoplas... Colonic Adenoca... Polyps of Colon Rectal Neoplasm... Rectal Adenocar...	CADe colonoscop...	50 Years - 69 Years	Fondazione Poliambulanza Istituto Ospedaliero
A Phase I Study of Bavituximab, Capecitabine, and Radiation for the Treatment of Rectal Adenocarcinoma	NCT01634685	Rectal Adenocar...	Radiation Bavituximab Capecitabine	18 Years - 99 Years	University of Texas Southwestern Medical Center
Predicting the Efficacy and Prognosis of Rectal Cancer Patients Based on ctDNA-MRD Technology	NCT05969938	Rectal Adenocar... Circulating Tum... Minimal Residua... Neoadjuvant Che...	MRD detection	18 Years - 75 Years	Sun Yat-sen University
Safety and Efficiency of Photodynamic Therapy for Rectal Cancer	NCT01872104	Advanced Rectal...	Photodynamic th...	25 Years - 75 Years	Central South University
Talimogene Laherparepvec, Chemotherapy, and Radiation Therapy Before Surgery in Treating Patients With Locally Advanced or Metastatic Rectal Cancer	NCT03300544	Locally Advance... Metastatic Rect... Rectal Adenocar... Stage III Recta... Stage IIIA Rect... Stage IIIB Rect... Stage IIIC Rect... Stage IV Rectal... Stage IVA Recta... Stage IVB Recta...	Capecitabine Fluorouracil Leucovorin Oxaliplatin Radiation Thera... Talimogene Lahe...	18 Years -	National Cancer Institute (NCI)
Phase I Study of Neoadjuvant Radiotherapy With 5-Fluorouracil for Rectal Cancer	NCT02270606	Mucinous Adenoc... Recurrent Recta... Signet Ring Ade... Rectal Adenocar... Stage IIA Recta... Stage IIB Recta... Stage IIC Recta... Stage IIIA Rect... Stage IIIB Rect... Stage IIIC Rect...	intensity-modul... fluorouracil oxaliplatin leucovorin calc... therapeutic con...	18 Years -	Virginia Commonwealth University
Monitoring Treatment Response With On-board DWI During Neo-adjuvant Chemo-radiation for Rectal Cancer Using Magnetic Resonance-guided-radiotherapy Systems	NCT03961776	Rectal Adenocar...	MRI-guided radi...	18 Years -	Institut Paoli-Calmettes
Factors Affecting the Results of Treatment of Patients With Colorectal Cancer	NCT06050447	Colorectal Canc... Colon Cancer Rectal Cancer Colorectal Aden... Colorectal Neop... Rectal Adenocar...	Right hemicolec... Left hemicolect... Sigmoid colon r... Anterior resect... Low anterior re... Abdominoperinea... Total Colectomy	18 Years -	Immanuel Kant Baltic Federal University
Pelvic Radiotherapy With Concurrent Neoadjuvant FOLFOX for Patients With Newly Diagnosed Rectal Adenocarcinoma	NCT02319304	Rectal Adenocar...	FOLFOX {5-fluor... Low dose fracti...	18 Years -	University of Maryland, Baltimore
Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer	NCT04703101	Locally Advance... Rectal Adenocar... Stage II Rectal... Stage IIA Recta... Stage IIB Recta... Stage IIC Recta... Stage III Recta... Stage IIIA Rect... Stage IIIB Rect... Stage IIIC Rect...	Capecitabine Fluorouracil Intensity-Modul... Leucovorin Oxaliplatin Quality-of-Life... Surveillance Total Mesorecta...	18 Years -	Jonsson Comprehensive Cancer Center
Chemo-radiotherapy as Main Treatment Strategy for Rectal Cancer. Can we Provide a More Precise and Effective Treatment	NCT03619668	Rectal Cancer Rectal Adenocar... Locally Advance...		18 Years -	Aalborg University Hospital
Safety and Efficiency of Photodynamic Therapy for Rectal Cancer	NCT01872104	Advanced Rectal...	Photodynamic th...	25 Years - 75 Years	Central South University
Proteomic Approach Using Matrix-assisted Laser Desorption/Ionization Tandem Time-of-flight (MALDI-TOF/TOF) of Tumor Response in Rectal Carcinoma After Radiochemotherapy	NCT00855946	Rectal Adenocar...		18 Years - 80 Years	University Hospital, Bordeaux
Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors	NCT04165772	Rectal Adenocar... Clinical Stage:... Stage III (Any ... Solid Tumor Solid Tumor, Ad...	TSR-042 or Dost... capecitabine or... Intensity Modul...	18 Years -	Memorial Sloan Kettering Cancer Center
Active Surveillance and Chemotherapy Before Surgery in Treating Participants With Stage II-III Rectal Cancer	NCT03594630	Rectal Adenocar... Stage II Rectal... Stage IIA Recta... Stage IIB Recta... Stage IIC Recta... Stage III Recta... Stage IIIA Rect... Stage IIIB Rect... Stage IIIC Rect...	Chemotherapy Patient Observa... Questionnaire A... Resection of Re...	18 Years -	M.D. Anderson Cancer Center
Neoadjuvant Chemoradiation With Bevacizumab for Chinese Rectal Cancer Patients	NCT01554059	Rectal Adenocar...	Bevacizumab Oxaliplatin 5-FU Radiotherapy	18 Years - 70 Years	Sixth Affiliated Hospital, Sun Yat-sen University
Safety and Efficiency of Photodynamic Therapy for Rectal Cancer	NCT01872104	Advanced Rectal...	Photodynamic th...	25 Years - 75 Years	Central South University
Mechanical Bowel Preparation and Oral Antibiotics Versus Mechanical Bowel Preparation Only Prior Rectal Surgery	NCT04281667	Rectal Adenocar... Rectum Neoplasm Rectum Carcinom... Colorectal Canc... Colorectal Neop... Colorectal Carc... Surgical Site I... Surgery--Compli...	Oral Antibiotic... Placebo Mechanical Bowe...	18 Years -	Helsinki University Central Hospital
Assessing the Additional Neoplasia Yield of Computer-aided Colonoscopy in a Screening Setting	NCT04441580	Colonic Neoplas... Colonic Adenoca... Polyps of Colon Rectal Neoplasm... Rectal Adenocar...	CADe colonoscop...	50 Years - 69 Years	Fondazione Poliambulanza Istituto Ospedaliero
Safety and Efficiency of Photodynamic Therapy for Rectal Cancer	NCT01872104	Advanced Rectal...	Photodynamic th...	25 Years - 75 Years	Central South University
Pelvic Radiotherapy With Concurrent Neoadjuvant FOLFOX for Patients With Newly Diagnosed Rectal Adenocarcinoma	NCT02319304	Rectal Adenocar...	FOLFOX {5-fluor... Low dose fracti...	18 Years -	University of Maryland, Baltimore
Factors Predicting Recurrence in Rectal Cancer After Surgery	NCT03899870	Rectal Cancer Rectal Adenocar...	Rectal resectio... Neoadjuvant the... Adjuvant therap...	-	Université de Sousse

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