The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
Brief Title: Frailty and Body Composition in the Elderly Cancer Patients Treated With Chemotherapy
Official Title: Frailty and Body Composition in the Elderly Cancer Patients Treated With Chemotherapy
Study ID: NCT02806154
Brief Summary: The investigators could hypothesize that age-related changes in body composition parameters play a role in the variable tolerance to chemotherapy in the elderly.
Detailed Description: However none of the studies relating body composition and chemotoxicity included elderly as a specific subpopulation. Furthermore in the majority of studies, body composition analyses are based on the estimation of muscle mass by CT scanner (axial L3 section). This method is to date not validated in the elderly cancer patients. Nevertheless some studies used Dual Energy X-ray Absorptiometry (DEXA), which is considered the gold standard in the assessment of body composition in older adults. The investigators main hypothesis is that the appendicular muscle mass (I.e. muscle mass of the 4 limbs) operationalized as an index by dividing the muscle mass by squared height following Baumgartners' approach (Baumgartner, 1998) measured by DEXA (total of muscle mass of 4 limbs / height ²) represents a predictive factor of chemotoxicity in the elderly. The finding that body composition is associated with poor tolerance of chemotherapy could lead to consider these parameters in the treatment decision of the elderly cancer patients and improve the current decision-making algorithms when treating older adults.
Minimum Age: 70 Years
Eligible Ages: OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Hôpital Sainte Marguerite, Marseille, , France
CH de Montauban, Montauban, , France
Institut du Cancer de Montpellier Val d'Aurelle, Montpellier, , France
CHU de Nantes, Nantes, , France
Hôpital de Cimiez, CHU Nice, Nice, , France
CH de Bigorre, Tarbes, , France
Hospital of Toulouse, Toulouse, , France
Institut Claudius Régaud, Toulouse, , France
Name: Laurent Balardy
Affiliation: University Hospital, Toulouse
Role: PRINCIPAL_INVESTIGATOR