Symptoms and General Pathology

All Conditions

Frailty

Elderly cancer patients treated with chemotherapy will have DEXA

The appendicular muscle mass measured by DEXA

DEXA

Laurent Balardy

The investigators could hypothesize that age-related changes in body composition parameters play a role in the variable tolerance to chemotherapy in the elderly.

However none of the studies relating body composition and chemotoxicity included elderly as a specific subpopulation. Furthermore in the majority of studies, body composition analyses are based on the estimation of muscle mass by CT scanner (axial L3 section). This method is to date not validated in the elderly cancer patients. Nevertheless some studies used Dual Energy X-ray Absorptiometry (DEXA), which is considered the gold standard in the assessment of body composition in older adults.

The investigators main hypothesis is that the appendicular muscle mass (I.e. muscle mass of the 4 limbs) operationalized as an index by dividing the muscle mass by squared height following Baumgartners' approach (Baumgartner, 1998) measured by DEXA (total of muscle mass of 4 limbs / height ²) represents a predictive factor of chemotoxicity in the elderly.

The finding that body composition is associated with poor tolerance of chemotherapy could lead to consider these parameters in the treatment decision of the elderly cancer patients and improve the current decision-making algorithms when treating older adults.

Frailty and Body Composition in the Elderly Cancer Patients Treated With Chemotherapy

Toxicity event defined by : first occurrence of grade 4 hematologic or grade 3-4 non hematologic toxicity as defined by the National Cancer Institute-Common Toxicity Criteria (NCI-CTC version 4) and/or disruption of chemotherapy because of inacceptable toxicity.

defined as a loss of ≥ 0.5 point in Activities of Daily Living Scale.

defined as a loss ≥ 1 point in the Short Physical Performance Battery

defined as a loss ≥ 10 points in the EORTC quality of life questionnaire (QLQ) QLQ-C30 questionnaire

defined by a death occuring during the 3 first months from the initiation of the treatment

University Hospital, Toulouse

Neoplasms

Skin and Connective Tissue Diseases

Nutritional and Metabolic Diseases

Breast Neoplasms

Obesity

Breast Diseases

Skin Diseases

Each patient will have a weekly goal of 2000 calories burned and 18 MET-hours of exercise which can be achieved in 4 to 7 hours of physical activity per week. Resistance training, using weight machines and aerobic training using treadmills, elliptical trainers and stationary bicycles, will be utilized in the intervention group.

The control group will receive basic information on physical activity but not be instructed.

Exercise Regimen

Breanne Eddington

Karen Milligan, MD

The proposed study compares the outcomes of a physical activity intervention begun at diagnosis, continuing through active cancer treatment and into six months of survivorship compared to the outcomes of a control group receiving limited information on activity.

Patients (with stage 0 to stage III breast cancer)receiving chemotherapy, radiation or both chemotherapy and radiation will be included in the study.Randomization will be stratified by disease stage at diagnosis, treatment modalities planned, and hormonal status. Each patient will have a weekly goal of 2000 calories burned and 18 MET-hours of exercise which can be achieved in 4 to 7 hours of physical activity per week. Resistance training, using weight machines and aerobic training using treadmills, elliptical trainers and stationary bicycles, will be utilized in the intervention group. The control group will receive basic information on physical activity but not be instructed. Any physical activity in this group will be self-reported. Change in C-reactive protein will be the primary endpoint. Changes in other laboratory values, DEXA measurements, and quality of life measurements will be secondary endpoints.

Breast Cancer Patients: A Breast Cancer Rehabilitation and Exercise Laboratory

Prescriptive Exercise Intervention During Active Treatment for Early Stage Breast Cancer Patients: A Breast Cancer Rehabilitation & Exercise Laboratory

The primary endpoint for this study change in C-reactive protein.

Compare changes in:

* Glucose
* Insulin
* Estradiol
* Testosterone

Body composition parameters and bone density will be assessed using Dual Energy X-ray Absorptiometry (DEXA) and compared between the two groups.

Quality of Life will be measured and compared between the groups

Comparing overall survival and progression free survival between groups.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Frailty and Body Composition in the Elderly Cancer Patients Treated With Chemotherapy	NCT02806154	Cancer	DEXA	70 Years -	University Hospital, Toulouse
Frailty and Body Composition in the Elderly Cancer Patients Treated With Chemotherapy	NCT02806154	Cancer	DEXA	70 Years -	University Hospital, Toulouse
Breast Cancer Patients: A Breast Cancer Rehabilitation and Exercise Laboratory	NCT01157130	Early Stage Bre...	Exercise Regime...	18 Years -	Nevada Cancer Institute

Spots Global Cancer Trial Database for dexa

Every month we try and update this database with for dexa cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for dexa

Every month we try and update this database with for dexa cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for dexa cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.