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Spots Global Cancer Trial Database for Tobacco and Alcohol Influence on Oncogenic Drivers and Somatic Evolution in the Oral Mucosa

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Trial Identification

Brief Title: Tobacco and Alcohol Influence on Oncogenic Drivers and Somatic Evolution in the Oral Mucosa

Official Title: Tobacco and Alcohol Influence on Oncogenic Drivers and Somatic Evolution in the Oral Mucosa

Study ID: NCT06094829

Interventions

Oral cytobrush

Study Description

Brief Summary: Head and neck cancers represent more than 500,000 cases per year worldwide, and often involve post-treatment relapse. The oral cavity is the most frequent site, but early disease stages are still insufficiently characterised and poorly detected. The study's aim is to better understand the oral mucosa somatic evolution, and how it can give rise to oral squamous cell carcinoma (OSCC). This is a multi-centric, descriptive, non-interventional cohort in healthy adult subjects. The aim of the study is to detect the presence of OSCC driver gene mutations in healthy subjects' oral mucosa, quantify whether they provide cells with a selective advantage, and study the impact of tobacco and alcohol consumption on the mutational load. This study will not allow to identify potential malignant cells, and will be usable for diagnostic purposes.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: Yes

Locations

Cabinet Libéral Picquendar, Bougival, , France

Cabinet Libéral Balayre, Chassieu, , France

Cabinet Libéral Debeauvais, Châtillon-Coligny, , France

Cabinet Libéral Finet, Fontaine-lès-Dijon, , France

Cabinet Libéral Jaeggy, Haguenau, , France

Unité de chirurgie et médecine orales (UCMO) - HCL - Hôpital Edouard Herriot- Pavillon R, Lyon, , France

Centre de Consultations et de Traitements Dentaires HCL, Lyon, , France

Cabinet Libéral Grammatica, Lyon, , France

Cabinet Libéral Cougot, Meudon, , France

Cabinet Libéral Calvo, Quint-Fonsegrives, , France

Cabinet Libéral Glomet, Saumur, , France

Cabinet Libéral Dutour, Theix, , France

Cabinet Libéral Masri, Vandœuvre-lès-Nancy, , France

Cabinet Libéral Bondil, Villefranche-sur-Saône, , France

Cabinet Libéral Janisset-Masse, Villiers-sur-Marne, , France

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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