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Brief Title: Tobacco and Alcohol Influence on Oncogenic Drivers and Somatic Evolution in the Oral Mucosa
Official Title: Tobacco and Alcohol Influence on Oncogenic Drivers and Somatic Evolution in the Oral Mucosa
Study ID: NCT06094829
Brief Summary: Head and neck cancers represent more than 500,000 cases per year worldwide, and often involve post-treatment relapse. The oral cavity is the most frequent site, but early disease stages are still insufficiently characterised and poorly detected. The study's aim is to better understand the oral mucosa somatic evolution, and how it can give rise to oral squamous cell carcinoma (OSCC). This is a multi-centric, descriptive, non-interventional cohort in healthy adult subjects. The aim of the study is to detect the presence of OSCC driver gene mutations in healthy subjects' oral mucosa, quantify whether they provide cells with a selective advantage, and study the impact of tobacco and alcohol consumption on the mutational load. This study will not allow to identify potential malignant cells, and will be usable for diagnostic purposes.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: Yes
Cabinet Libéral Picquendar, Bougival, , France
Cabinet Libéral Balayre, Chassieu, , France
Cabinet Libéral Debeauvais, Châtillon-Coligny, , France
Cabinet Libéral Finet, Fontaine-lès-Dijon, , France
Cabinet Libéral Jaeggy, Haguenau, , France
Unité de chirurgie et médecine orales (UCMO) - HCL - Hôpital Edouard Herriot- Pavillon R, Lyon, , France
Centre de Consultations et de Traitements Dentaires HCL, Lyon, , France
Cabinet Libéral Grammatica, Lyon, , France
Cabinet Libéral Cougot, Meudon, , France
Cabinet Libéral Calvo, Quint-Fonsegrives, , France
Cabinet Libéral Glomet, Saumur, , France
Cabinet Libéral Dutour, Theix, , France
Cabinet Libéral Masri, Vandœuvre-lès-Nancy, , France
Cabinet Libéral Bondil, Villefranche-sur-Saône, , France
Cabinet Libéral Janisset-Masse, Villiers-sur-Marne, , France