Spots Global Cancer Trial Database for oral squamous cell carcinoma
Every month we try and update this database with for oral squamous cell carcinoma cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| WORST PATTERN OF INVASION IN ORAL SQUAMOUS CELL CARCINOMA | NCT05927220 | Oral Cancer Oral Cavity Can... Oral Squamous C... | Biopsy Specimen... | 18 Years - 80 Years | Armed Forces Institute of Pathology Rawalpindi | |
| Determination of ALDH1b1 and ALDH2 Polymorphisms Frequency in the Brazilian Population | NCT04270201 | Oral Squamous C... | Saliva collecti... | 18 Years - | Instituto do Cancer do Estado de São Paulo | |
| Neoadjuvant Toripalimab Plus Nimotuzumab in Oral Squamous Cell Carcinoma Prior to Radical Therapy | NCT05803915 | Oral Squamous C... | Toripalimab | 18 Years - | Peking Union Medical College Hospital | |
| Prediction of Malignant Transformation of Oral Leukoplakia Using a MAGE-A-based Immunoscore | NCT03975322 | Oral Leukoplaki... Oral Leukoplaki... Oral Leukoplaki... Oral Lichen Pla... | 18 Years - 80 Years | University of Erlangen-Nürnberg Medical School | ||
| Tobacco and Alcohol Influence on Oncogenic Drivers and Somatic Evolution in the Oral Mucosa | NCT06094829 | Carcinoma, Squa... | Oral cytobrush | 18 Years - | Hospices Civils de Lyon | |
| "Ultra-High Frequency intraOral UltraSonography of the TONgue" (HOUSTON) | NCT06336941 | Oral Squamous C... | Ultrasound | 18 Years - | University of Pisa | |
| Survival Benefit of Elective Neck Dissection in T1,2N0M0 Oral Squamous Cell Carcinoma | NCT01334320 | Oral Squamous C... | elective neck d... | 20 Years - 70 Years | Sun Yat-sen University | |
| Assessment of Anti-cancerous Effect of Green, Roasted and Decaffeinated Coffee on Oral Squamous Cell Carcinoma Cell Line | NCT03619304 | Oral Squamous C... | coffee | - | Cairo University | |
| A Prospective, Single-arm Phase II Clinical Trial of Tislelizumab Combined With Platinum Doublet Neoadjuvant Therapy to Improve Mandibular Preservation in Resectable Locally Advanced Oral Squamous Cell Carcinoma. | NCT06130007 | Oral Squamous C... | Three-Week Trea... | 18 Years - 70 Years | Sun Yat-sen University | |
| Developing an In-vitro Diagnostic Risk-Stratification Test for Oral Cancer | NCT01587573 | Oral Squamous C... | saliva collecti... | 18 Years - | PeriRx | |
| Neoadjuvant Personalized Anti-PD-1 and Anti-VEGFR Therapy in OSCC Patients | NCT05069857 | Oral Squamous C... Neoadjvant Ther... Anti-PD-1 Anti-VEGFR | Camrelizumab (a... Apatinib (anti-... | 18 Years - 75 Years | Shanghai Jiao Tong University School of Medicine | |
| Using Vitamin D to Reduce Oral Mucosal Inflammation in Chemotherapy Patients With Oral Squamous Cell Carcinoma | NCT06016400 | Oral Squamous C... Oral Mucositis | Alfacalcidol Or... Placebo | 20 Years - 70 Years | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | |
| Neoadjuvant Immunochemotherapy for LAOSCC | NCT06258811 | Oral Squamous C... Locally Advance... | albumin paclita... | 18 Years - 75 Years | Huashan Hospital | |
| The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related Osteonecrosis of the Jaw | NCT03418454 | Oral Squamous C... Medication Rela... Oral Epithelial... | Buccal mucosa s... | 20 Years - 90 Years | Barzilai Medical Center | |
| Verification of Saliva MMP-1 as a Diagnostic Marker of Oral Cavity Cancer | NCT05049408 | Oral Squamous C... | MMP-1 Enzyme Li... | 20 Years - | S&T Biomed Co., Ltd. | |
| Neoadjuvant Anti-PD-1 Immunotherapy With Chemotherapy in Resectable Locally Advanced Oral Squamous Cell Carcinoma | NCT05798793 | Oral Squamous C... | Camrelizumab pl... TP | 18 Years - 70 Years | Hospital of Stomatology, Wuhan University | |
| The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related Osteonecrosis of the Jaw | NCT03418454 | Oral Squamous C... Medication Rela... Oral Epithelial... | Buccal mucosa s... | 20 Years - 90 Years | Barzilai Medical Center | |
| Assessment of Bmi-1 on Protein and Molecular Levels in Oral Dysplasia and Squamous Cell Carcinoma: A Diagnostic Study | NCT03345966 | Oral Squamous C... | Bmi-1 antibody | - | Cairo University | |
| Neoadjuvant Sintilimab in Combination With Carboplatin and Nab-paclitaxel in Resectable Oral Cavity or Oropharyngeal Squamous Cell Carcinoma | NCT04718415 | Oral Squamous C... Oropharyngeal S... | sintilimab, pac... Surgical resect... | 18 Years - 80 Years | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | |
| Hepatitis C Virus Detection in Oral Squamous Cell Carcinoma | NCT03109457 | Hepatitis C | oral squamous c... | - | Cairo University | |
| Detection of Oral and Throat Cancers Using OralViome Cancer Testing System | NCT05451303 | Oral Squamous C... Oropharynx Squa... Premalignant Le... | OralViome Cance... | 18 Years - | Viome | |
| A Study of Vobramitamab Duocarmazine in Participants With Metastatic Castration Resistant Prostate Cancer and Other Solid Tumors | NCT05551117 | Castration-Resi... Androgen-Indepe... Androgen-Insens... Androgen-Resist... Hormone Refract... Anal Cancer Anal Neoplasm Carcinoma, Squa... Head and Neck S... Laryngeal Squam... Oral Squamous C... Malignant Melan... Melanoma Non-small Cell ... Non-small Cell ... Small-cell Lung... Small Cell Carc... | vobramitamab du... vobramitamab du... vobramitamab du... | 18 Years - | MacroGenics | |
| Assessment of Anti-cancerous Effect of Green, Roasted and Decaffeinated Coffee on Oral Squamous Cell Carcinoma Cell Line | NCT03619304 | Oral Squamous C... | coffee | - | Cairo University | |
| Detection of Oral and Throat Cancers Using OralViome Cancer Testing System | NCT05451303 | Oral Squamous C... Oropharynx Squa... Premalignant Le... | OralViome Cance... | 18 Years - | Viome | |
| A Study of Neoadjuvant Bio-C/T Followed by Concurrent Bio-R/T in High-risk Locally Advanced Oral Squamous Cell Carcinoma | NCT00933387 | Oral Cancer | Cetuximab,Pacli... | 18 Years - 70 Years | National Health Research Institutes, Taiwan | |
| Assessment of Anti-cancerous Effect of Green, Roasted and Decaffeinated Coffee on Oral Squamous Cell Carcinoma Cell Line | NCT03619304 | Oral Squamous C... | coffee | - | Cairo University | |
| Elective vs Therapeutic Neck Dissection in Treatment of Patients With Clinical T1/2N1M0 Oral Squamous Cell Carcinoma | NCT05806073 | Oral Squamous C... Neck Dissection | Elective neck d... Therapeutic nec... | 18 Years - 75 Years | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | |
| Safety and Efficacy Study of PRV211 in Subjects With Oral Squamous Cell Carcinoma | NCT05893888 | Oral Squamous C... | PRV211 (Intraop... | 18 Years - | Privo Technologies | |
| Epigenetic Biomarkers in the Saliva for the Diagnosis of Squamous Cells Carcinoma of the Oral Cavity | NCT05791149 | Oral Squamous C... Maxillo-facial ... Biomarkers Saliva DNA Methylation Epigenetics | saliva tube | 18 Years - | Centre Hospitalier Universitaire, Amiens | |
| TPF Induction Chemotherapy for Locally Advanced and Resectable Oral Squamous Cell Carcinoma | NCT01542931 | Stage III Oral ... Stage IVA Oral ... | TPF induction c... | 18 Years - 75 Years | Shanghai Jiao Tong University School of Medicine | |
| Neoadjuvant Treatment of Tislelizumab Combined Chemotherapy for Locally Advanced Oral Squamous Cell Carcinoma ：A Single-arm, Prospective, Phase II Trial | NCT05862168 | Oral Squamous C... | Tislelizumab Albumin paclita... Cisplatin 5-Fluorouracil | 18 Years - 75 Years | Zhejiang University | |
| Tobacco and Alcohol Influence on Oncogenic Drivers and Somatic Evolution in the Oral Mucosa | NCT06094829 | Carcinoma, Squa... | Oral cytobrush | 18 Years - | Hospices Civils de Lyon | |
| The Long Non Coding MALAT1 as a Potential Salivary Diagnostic Biomarker in Oral Squamous Cell Carcinoma Through Targeting mi RNA 124 | NCT05708209 | Oral Squamous C... | 20 Years - 65 Years | Fayoum University | ||
| TPExtreme Induced Chemotherapy Followed by Surgery and Radiotherapy in the Oral Carcinoma. | NCT05872880 | Oral Squamous C... Locally Advance... | Modified radica... Radical surgery | 18 Years - 65 Years | Xiangya Hospital of Central South University | |
| TPExtreme Induced Chemotherapy Followed by Surgery and Radiotherapy in the Oral Carcinoma. | NCT05872880 | Oral Squamous C... Locally Advance... | Modified radica... Radical surgery | 18 Years - 65 Years | Xiangya Hospital of Central South University | |
| Evaluation of the Levels of Salivary Paxillin Oral Premalignant and Malignant Lesions | NCT06154551 | Comparison of S... | Paxillin biomar... | 30 Years - 70 Years | Cairo University | |
| Neoadjuvant Immunochemotherapy for LAOSCC | NCT06258811 | Oral Squamous C... Locally Advance... | albumin paclita... | 18 Years - 75 Years | Huashan Hospital | |
| Postoperative Radiotherapy for Oral Squamous Cell Carcinoma After Neoadjuvant Therapy and Surgery | NCT05455632 | Radiotherapy Neoadjuvant The... Oral Squamous C... Surgery | 18 Years - 75 Years | Shanghai Jiao Tong University School of Medicine | ||
| Neoadjuvant Personalized Anti-PD-1 and Anti-VEGFR Therapy in OSCC Patients | NCT05069857 | Oral Squamous C... Neoadjvant Ther... Anti-PD-1 Anti-VEGFR | Camrelizumab (a... Apatinib (anti-... | 18 Years - 75 Years | Shanghai Jiao Tong University School of Medicine | |
| Melatonin Effect in Combination With Neoadjuvant Chemotherapy to Clinical Response in Locally Advanced Oral Squamous Cell Carcinoma | NCT04137627 | Oral Squamous C... Neoadjuvant Che... | Melatonin 20 MG... Placebo oral ca... | - | Indonesia University | |
| Tolerance and Benefits of Mandibular Advanced Device for Snoring and Sleep Apnea in Oropharyngeal Cancer. | NCT05719779 | Oral Cancer Pharynx Cancer Sleep Apnea Snoring Oral Squamous C... | Ronco-Onco and ... | 18 Years - 65 Years | Centre hospitalier de l'Université de Montréal (CHUM) | |
| Neoadjuvant Treatment of Tislelizumab Combined Chemotherapy for Locally Advanced Oral Squamous Cell Carcinoma ：A Single-arm, Prospective, Phase II Trial | NCT05862168 | Oral Squamous C... | Tislelizumab Albumin paclita... Cisplatin 5-Fluorouracil | 18 Years - 75 Years | Zhejiang University | |
| Laser Mucite ORL : Effectiveness of Laser Therapy for Mucositis Induced by a Radio-chemotherapy in Head and Neck Cancer | NCT01772706 | Oral Squamous C... Squamous Cell C... Squamous Cell C... Oral Mucositis | low level laser... placebo (laser ... | 18 Years - 75 Years | Institut Cancerologie de l'Ouest | |
| Concurrent Radiotherapy and/or Cisplatin With or Without Celecoxib in Patients With Primary Oral Squamous Cell Carcinoma | NCT02739204 | Oral Squamous C... | Celecoxib | 20 Years - 80 Years | China Medical University Hospital | |
| Methylation of p16 CpG Island And Malignant Transformation of Oral Epithelial Dysplasia | NCT00835341 | Oral Epithelial... | - | Peking University | ||
| A Study of TC(Docetaxel and Carboplatin) Regimen With or Without Nimotuzumab in Recurrent Metastatic Oral Squamous Cell Carcinoma | NCT04367909 | Oral Squamous C... | Nimotuzumab Docetaxel Carboplatin | 18 Years - 75 Years | China Three Gorges University, Yichang, China | |
| Toluidine Blue Versus Frozen Sections for Assessment of Tumor Margins in Oral Squamous Cell Carcinoma | NCT03554967 | Oral Squamous C... | - | Cairo University | ||
| Melatonin Effect in Combination With Neoadjuvant Chemotherapy to Clinical Response in Locally Advanced Oral Squamous Cell Carcinoma | NCT04137627 | Oral Squamous C... Neoadjuvant Che... | Melatonin 20 MG... Placebo oral ca... | - | Indonesia University | |
| Epigenetic Biomarkers in the Saliva for the Diagnosis of Squamous Cells Carcinoma of the Oral Cavity | NCT05791149 | Oral Squamous C... Maxillo-facial ... Biomarkers Saliva DNA Methylation Epigenetics | saliva tube | 18 Years - | Centre Hospitalier Universitaire, Amiens | |
| A Study on Tumor Budding Guiding Individualized Surgical Planning of Early-stage Oral Squamous Cell Carcinoma. | NCT02743832 | Carcinoma, Squa... | Resection for p... Resection for p... | 20 Years - 70 Years | Sun Yat-sen University | |
| Neoadjuvant Treatment of Tislelizumab Combined Chemotherapy for Locally Advanced Oral Squamous Cell Carcinoma ：A Single-arm, Prospective, Phase II Trial | NCT05862168 | Oral Squamous C... | Tislelizumab Albumin paclita... Cisplatin 5-Fluorouracil | 18 Years - 75 Years | Zhejiang University | |
| Neoadjuvant PD-1 Blockade in Resectable Oral Squamous Cell Carcinoma | NCT04649476 | Oral Squamous C... | Camrelizumab Camrelizumanb p... | 18 Years - 70 Years | Hospital of Stomatology, Wuhan University | |
| Predicting Metastatic Oral Squamous Cell Carcinomas With Molecular Biomarkers Using Machine Learning | NCT04543266 | Oral Squamous C... | Surgery | - | The University of Hong Kong | |
| Molecular Mechanisms of the Development of Precancerous and Cancerous Lesions of the Oral Cavity | NCT03026361 | Oral Lichen Pla... Oral Squamous C... | global proteomi... | 30 Years - 70 Years | University of Zagreb | |
| A Study of Vobramitamab Duocarmazine in Participants With Metastatic Castration Resistant Prostate Cancer and Other Solid Tumors | NCT05551117 | Castration-Resi... Androgen-Indepe... Androgen-Insens... Androgen-Resist... Hormone Refract... Anal Cancer Anal Neoplasm Carcinoma, Squa... Head and Neck S... Laryngeal Squam... Oral Squamous C... Malignant Melan... Melanoma Non-small Cell ... Non-small Cell ... Small-cell Lung... Small Cell Carc... | vobramitamab du... vobramitamab du... vobramitamab du... | 18 Years - | MacroGenics | |
| Neoadjuvant Sintilimab in Combination With Carboplatin and Nab-paclitaxel in Resectable Oral Cavity or Oropharyngeal Squamous Cell Carcinoma | NCT04718415 | Oral Squamous C... Oropharyngeal S... | sintilimab, pac... Surgical resect... | 18 Years - 80 Years | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | |
| Salivary Expression of SOX7 in Oral Squamous Cell Carcinoma: Diagnostic Accuracy Study | NCT06031337 | Oral Cancer Oral Squamous C... | ELISA | 12 Years - | Fayoum University | |
| Salivary LINC00657 as a Diagnostic Biomarker for Oral Squamous Cell Carcinoma | NCT05821179 | Oral Squamous C... | 20 Years - 70 Years | Fayoum University | ||
| Hepatitis C Virus Detection in Oral Squamous Cell Carcinoma | NCT03109457 | Hepatitis C | oral squamous c... | - | Cairo University | |
| Concurrent Radiotherapy and/or Cisplatin With or Without Celecoxib in Patients With Primary Oral Squamous Cell Carcinoma | NCT02739204 | Oral Squamous C... | Celecoxib | 20 Years - 80 Years | China Medical University Hospital | |
| Neoadjuvant Anti-PD-1 Immunotherapy With Chemotherapy in Resectable Locally Advanced Oral Squamous Cell Carcinoma | NCT05798793 | Oral Squamous C... | Camrelizumab pl... TP | 18 Years - 70 Years | Hospital of Stomatology, Wuhan University | |
| Safety and Efficacy Study of PRV111 in Subjects With Oral Squamous Cell Carcinoma | NCT03502148 | Oral Squamous C... | PRV111 (Cisplat... | 18 Years - | Privo Technologies | |
| Prediction of Malignant Transformation of Oral Leukoplakia Using a MAGE-A-based Immunoscore | NCT03975322 | Oral Leukoplaki... Oral Leukoplaki... Oral Leukoplaki... Oral Lichen Pla... | 18 Years - 80 Years | University of Erlangen-Nürnberg Medical School | ||
| TPExtreme Induced Chemotherapy Followed by Surgery and Radiotherapy in the Oral Carcinoma. | NCT05872880 | Oral Squamous C... Locally Advance... | Modified radica... Radical surgery | 18 Years - 65 Years | Xiangya Hospital of Central South University | |
| Neoadjuvant Tislelizumab Plus Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer (NeoSPOT) | NCT06009861 | Oral Squamous C... Oropharyngeal S... | Tislelizumab Albumin-Bound P... Cisplatin | 18 Years - 80 Years | Peking University Hospital of Stomatology | |
| Effect of COX-2 and EGFR Suppression on Molecular Markers of Angiogenesis and Proliferation in Squamous Cell Carcinoma of Oral Cavity - Prospective Randomized Study | NCT02748707 | Oral Squamous C... Carcinoma of Bu... Tongue Cancers Head and Neck C... | Arm1 Arm 2 Arm 3 Arm 4 | 18 Years - 75 Years | Tata Memorial Hospital | |
| Tobacco and Alcohol Influence on Oncogenic Drivers and Somatic Evolution in the Oral Mucosa | NCT06094829 | Carcinoma, Squa... | Oral cytobrush | 18 Years - | Hospices Civils de Lyon | |
| Gross Examinations Versus Frozen Section for Assessment of Surgical Margins in Oral Cancers | NCT04809324 | Oral Cavity Can... | Gross examinati... Frozen section | 18 Years - 100 Years | Tata Memorial Centre | |
| Using MASL to Combat Oral Cancer | NCT04188665 | Squamous Cell C... | MASL Placebo | 18 Years - | Rowan University | |
| Verification of Saliva MMP-1 as a Diagnostic Marker of Oral Cavity Cancer | NCT05049408 | Oral Squamous C... | MMP-1 Enzyme Li... | 20 Years - | S&T Biomed Co., Ltd. | |
| Determination of ALDH1b1 and ALDH2 Polymorphisms Frequency in the Brazilian Population | NCT04270201 | Oral Squamous C... | Saliva collecti... | 18 Years - | Instituto do Cancer do Estado de São Paulo | |
| Laser Mucite ORL : Effectiveness of Laser Therapy for Mucositis Induced by a Radio-chemotherapy in Head and Neck Cancer | NCT01772706 | Oral Squamous C... Squamous Cell C... Squamous Cell C... Oral Mucositis | low level laser... placebo (laser ... | 18 Years - 75 Years | Institut Cancerologie de l'Ouest | |
| Toluidine Blue Versus Frozen Sections for Assessment of Tumor Margins in Oral Squamous Cell Carcinoma | NCT03554967 | Oral Squamous C... | - | Cairo University | ||
| Early Prediction of Oral Cancer by S100A7 Immunohistochemistry Signature-based Assessment | NCT04622462 | Oral Neoplasm | Standard of Car... STRATICYTE Asse... | 15 Years - 90 Years | Proteocyte Diagnostics Inc. | |
| Association of Salivary Amino Acid Level With OSCC Identified By Liquid Chromatography Mass Spectroscopy | NCT05150509 | Oral Squamous C... | Oral Squamous C... | - | Bangladesh Reference Institute of Chemical Measurements (BRICM) | |
| Dissecting the Heterogeneity of Oral Cancer Pain | NCT05024383 | Oral Squamous C... | Chemical sensit... Mechanical sens... | 18 Years - | NYU College of Dentistry | |
| Neoadjuvant Tislelizumab Plus Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer (NeoSPOT) | NCT06009861 | Oral Squamous C... Oropharyngeal S... | Tislelizumab Albumin-Bound P... Cisplatin | 18 Years - 80 Years | Peking University Hospital of Stomatology | |
| Methylation of p16 CpG Island And Malignant Transformation of Oral Epithelial Dysplasia | NCT00835341 | Oral Epithelial... | - | Peking University | ||
| Concurrent Radiotherapy and/or Cisplatin With or Without Celecoxib in Patients With Primary Oral Squamous Cell Carcinoma | NCT02739204 | Oral Squamous C... | Celecoxib | 20 Years - 80 Years | China Medical University Hospital | |
| Salivary LINC00657 as a Diagnostic Biomarker for Oral Squamous Cell Carcinoma | NCT05821179 | Oral Squamous C... | 20 Years - 70 Years | Fayoum University |
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