Spots Global Cancer Trial Database for Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer Types

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Trial Identification

Brief Title: Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer Types

Official Title: Maximizing Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer Types

Study ID: NCT06075524

Conditions

Clinical Stage III Cutaneous Melanoma AJCC v8

Clinical Stage IV Cutaneous Melanoma AJCC v8

Locally Advanced Lung Carcinoma

Locally Advanced Malignant Solid Neoplasm

Locally Advanced Melanoma

Metastatic Lung Carcinoma

Metastatic Malignant Solid Neoplasm

Metastatic Melanoma

Stage III Lung Cancer AJCC v8

Stage IV Lung Cancer AJCC v8

Interventions

Biospecimen Collection

Electronic Health Record Review

Study Description

Brief Summary: This study explores the role of T cells in monitoring disease status and response during anti-PD-1/PD-L1 treatment in patients with melanoma, lung and other cancer types. Measuring levels of specific targets such as Bim and soluble PD-L1 during therapy may help track treatment resistance and clinical outcomes. This information may also help researchers determine why some people with melanoma, lung and other cancer types respond to PD-1/PD-L1 treatment and others do not.

Detailed Description: PRIMARY OBJECTIVES: I. Establish the role of Bim for monitoring disease status during anti-PD-1 therapy. II. Identify the mechanisms of resistance to anti-PD-1 blockade. III. Quantify and modulate levels of NKG7 messenger ribonucleic acid (mRNA) in CD8+ T cells. OUTLINE: This is an observational study. Patients undergo blood sample collection throughout the study. Patients also undergo optional stool sample collection and have their medical records reviewed on study. In addition, patients provide previously-collected tissue sample, if available.