Spots Global Cancer Trial Database for stage iv lung cancer ajcc v8

Every month we try and update this database with for stage iv lung cancer ajcc v8 cancer trials from around the world to help patients and their families find trials that might be right for them.
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We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Adaptive Radiation Planning for the Reduction of Radiation-Induced Toxicity in Patients With Stage II-IV Non-small Cell Lung Cancer	NCT04751747	Locally Advance... Metastatic Lung... Stage II Lung C... Stage IIA Lung ... Stage IIB Lung ... Stage III Lung ... Stage IIIA Lung... Stage IIIB Lung... Stage IIIC Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ... Unresectable Lu...	Computed Tomogr... Contrast Agent	18 Years -	Rutgers, The State University of New Jersey
Poziotinib and Ramucirumab for the Treatment of EGFR Exon 20 Mutant Stage IV Non-small Cell Lung Cancer	NCT05045404	Metastatic Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Poziotinib Hydr... 1429757-68-5, H...	18 Years -	M.D. Anderson Cancer Center
Biologically Guided Radiation Therapy (BgRT) and Stereotactic Body Radiation Therapy (SBRT) With Osimertinib for the Treatment of Patients With Oligoprogressive EGFR Positive Non-small Cell Lung Carcinoma	NCT06014827	Lung Non-Small ... Stage IV Lung C...	Biospecimen Col... Computed Tomogr... Osimertinib Positron Emissi... Stereotactic Bo... Survey Administ...	18 Years -	City of Hope Medical Center
EMB-01 in Combination With Osimertinib in Patients With EGFR Mutant Lung Cancer	NCT05498389	Metastatic Lung... Advanced Lung N... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ... Stage III Lung ... Stage IIIA Lung... Stage IIIB Lung... EGFR Mutation-R...	EMB-01 Osimertinib	18 Years -	Shanghai EpimAb Biotherapeutics Co., Ltd.
Local Consolidative Therapy and Brigatinib in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer	NCT03707938	Advanced Lung C... ALK Gene Rearra... Lung Non-Small ... Recurrent Lung ... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Brigatinib Local Consolida...	18 Years -	M.D. Anderson Cancer Center
A Multiple Antigen Vaccine (STEMVAC) for the Treatment of Patients With Stage IV Non-Small Cell Lung Cancer	NCT05242965	Lung Non-Small ... Stage IV Lung C...	CD105/Yb-1/SOX2... Sargramostim Computed Tomogr... Biopsy Biospecimen Col...	18 Years -	University of Washington
Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer	NCT06287775	Extensive Stage... Stage IV Lung C...	Atezolizumab Biopsy Biospecimen Col... Computed Tomogr... Durvalumab Echocardiograph... Iadademstat Magnetic Resona... Multigated Acqu...	18 Years -	National Cancer Institute (NCI)
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy	NCT03965689	Metastatic Lung... Metastatic Lung... Stage IIIB Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ... Unresectable Lu... Unresectable Lu...	Carboplatin Paclitaxel Pevonedistat	18 Years -	National Cancer Institute (NCI)
Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer	NCT04181060	Advanced Lung N... Metastatic Lung... Recurrent Lung ... Stage IIIB Lung... Stage IV Lung C...	Bevacizumab Biospecimen Col... Computed Tomogr... Echocardiograph... Magnetic Resona... Multigated Acqu... Osimertinib	18 Years -	National Cancer Institute (NCI)
18F-FMAU PET/CT and MRI for the Detection of Brain Tumors in Patients With Brain Cancer or Brain Metastases	NCT04752267	Anatomic Stage ... Clinical Stage ... Glioma Malignant Brain... Metastatic Brea... Metastatic Colo... Metastatic Kidn... Metastatic Lung... Metastatic Mali... Metastatic Mela... Pathologic Stag... Prognostic Stag... Stage IV Colon ... Stage IV Lung C... Stage IV Renal ... Stage IVA Colon... Stage IVA Lung ... Stage IVB Colon... Stage IVB Lung ... Stage IVC Colon...	Computed Tomogr... 18F-FMAU Multiparametric... Positron Emissi...	18 Years -	University of Southern California
Single Fraction Stereotactic Body Radiation Therapy After Surgery in Treating Patients With Non-small Cell Lung Cancer	NCT04073745	Lung Non-Small ... Positive Surgic... Resected Mass Stage III Lung ... Stage IIIA Lung... Stage IIIB Lung... Stage IIIC Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Quality-of-Life... Questionnaire A... Stereotactic Bo...	18 Years -	Roswell Park Cancer Institute
Supportive Care Intervention (ROAR-LCT) for Patients With Stage IIIA, IIIB, and IV Lung Cancer, ROAR-LCT Trial	NCT05339022	Advanced Lung N... Advanced Lung S... Extensive Stage... Stage IIIA Lung... Stage IIIB Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ... Unresectable Lu... Unresectable Lu...	Best Practice Exercise Interv... Physical Therap... Quality-of-Life... Questionnaire A... Relaxation Ther...	60 Years -	Ohio State University Comprehensive Cancer Center
Aurora Kinase Inhibitor LY3295668 in Combination With Osimertinib for the Treatment of Advanced or Metastatic EGFR-Mutant Non-squamous Non-small Cell Lung Cancer	NCT05017025	Advanced Lung N... Metastatic Lung... Stage III Lung ... Stage IIIA Lung... Stage IIIB Lung... Stage IIIC Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Aurora A Kinase... Osimertinib	18 Years -	M.D. Anderson Cancer Center
4D PET/CT in Diagnosing Participants With Lung and Colorectal Cancer With Liver and Lung Metastasis	NCT00862680	Metastatic Mali... Metastatic Mali... Stage IV Colore... Stage IV Lung C... Stage IVA Color... Stage IVA Lung ... Stage IVB Color... Stage IVB Lung ... Stage IVC Color...	4-Dimensional C... 4D PET Scan	18 Years -	M.D. Anderson Cancer Center
Gilteritinib for the Treatment of ALK NSCLC	NCT06225427	Lung Non-Small ... Stage IV Lung C...	Biopsy Biospecimen Col... Computed Tomogr... Echocardiograph... Gilteritinib Magnetic Resona... Questionnaire A...	18 Years -	University of Michigan Rogel Cancer Center
Genetics and Shared Decision Making in Improving Care for Patients With Stage IVA-C Non-small Cell Lung Cancer	NCT03944265	Activating ALK ... Activating EGFR... Activating ROS1... Health Care Pro... Lung Non-Small ... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Counseling Questionnaire A... Medical Chart R...	18 Years -	Thomas Jefferson University
Phase IB Study to Evaluate the Safety of Selinexor (KPT-330) in Combination With Multiple Standard Chemotherapy or Immunotherapy Agents in Patients With Advanced Malignancies	NCT02419495	Advanced Malign... Clinical Stage ... Clinical Stage ... Fallopian Tube ... Metastatic Lung... Metastatic Mali... Metastatic Mela... Metastatic Rena... Ovarian Carcino... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Primary Periton... Stage III Lung ... Stage III Renal... Stage IIIA Lung... Stage IIIB Lung... Stage IIIC Lung... Stage IV Lung C... Stage IV Renal ... Stage IVA Lung ... Stage IVB Lung ... Triple-Negative... Unresectable Lu... Unresectable Me... Unresectable Re...	Capecitabine Carboplatin Cyclophosphamid... Doxorubicin Eribulin Fluorouracil Ipilimumab Irinotecan Hydr... Leucovorin Calc... Nivolumab Olaparib Oxaliplatin Paclitaxel Pembrolizumab Pemetrexed Selinexor Topotecan	18 Years -	M.D. Anderson Cancer Center
A Biobehavioral/Cognitive Treatment for Stress, Depression, and Anxiety in Patients With Stage IV Lung Cancer	NCT05342571	Advanced Lung C... Metastatic Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Behavioral, Psy... Biospecimen Col... Electronic Heal... Informational I... Survey Administ...	18 Years -	Ohio State University Comprehensive Cancer Center
Genetically Engineered Cells (MAGE-A1-specific T Cell Receptor-transduced Autologous T-cells) and Atezolizumab for the Treatment of Metastatic Triple Negative Breast Cancer, Urothelial Cancer, or Non-small Cell Lung Cancer	NCT04639245	Anatomic Stage ... Metastatic Lung... Metastatic Mali... Metastatic Trip... Metastatic Urot... Stage IV Lung C...	Atezolizumab Cyclophosphamid... Fludarabine MAGE-A1-specifi... PD1 Inhibitor	18 Years -	Fred Hutchinson Cancer Center
Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability	NCT04804644	Metastatic Lung... Metastatic Mali... Recurrent Lung ... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Memantine Hydro... Neurocognitive ... Stereotactic Ra... Whole-Brain Rad...	18 Years -	NRG Oncology
Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin and Gemcitabine) for Advanced Solid Tumors With Emphasis on Urothelial Cancer	NCT04491942	Advanced Bile D... Advanced Breast... Advanced Cervic... Advanced Endome... Advanced Esopha... Advanced Gastri... Advanced Head a... Advanced Lung N... Advanced Lung S... Advanced Malign... Advanced Ovaria... Advanced Penile... Advanced Pleura... Advanced Urothe... Anatomic Stage ... Anatomic Stage ... Clinical Stage ... Clinical Stage ... Stage III Cervi... Stage III Dista... Stage III Intra... Stage III Lung ... Stage III Ovari... Stage III Penil... Stage III Pleur... Stage IV Cervic... Stage IV Distal... Stage IV Intrah... Stage IV Lung C... Stage IV Ovaria... Stage IV Penile... Stage IV Pleura... Triple-Negative... Unresectable Ur...	Cisplatin Elimusertib Gemcitabine Hyd...	18 Years -	National Cancer Institute (NCI)
Testing the Addition of Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in People With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery	NCT04588246	Anatomic Stage ... Metastatic Brea... Metastatic Dige... Metastatic Lung... Metastatic Mali... Metastatic Mela... Metastatic Rena... Prognostic Stag... Recurrent Brain... Stage IV Lung C... Stage IV Renal ... Stage IVA Lung ... Stage IVB Lung ...	Memantine Quality-of-Life... Questionnaire A... Stereotactic Ra... Whole-Brain Rad...	18 Years -	NRG Oncology
Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease	NCT03025256	Acral Lentigino... Central Nervous... Clinical Stage ... Leptomeningeal ... Melanocytoma Metastatic Lung... Metastatic Mela... Metastatic Muco... Metastatic Uvea... Stage IV Lung C...	Biospecimen Col... Computed Tomogr... Lumbar Puncture Magnetic Resona... Nivolumab Positron Emissi...	18 Years -	M.D. Anderson Cancer Center
Abexinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumor Malignancies	NCT03590054	Stage III Cutan... Stage IV Cutane... Locally Advance... Locally Advance... Metastatic Head... Metastatic Mali... Metastatic Mela... Metastatic Urot... Non-Small Cell ... Stage IB Lung C... Stage III Cutan... Stage III Lung ... Stage III Urete... Stage IIIA Lung... Stage IIIB Lung... Stage IIIC Lung... Stage IV Cutane... Stage IV Lung C... Stage IV Ureter... Stage IVA Lung ... Stage IVB Lung ...	Abexinostat Pembrolizumab	18 Years -	University of California, San Francisco
Testing the Use of Targeted Treatment (AMG 510) for KRAS G12C Mutated Advanced Non-squamous Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)	NCT04625647	Lung Adenocarci... Lung Non-Small ... Recurrent Lung ... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Sotorasib	18 Years -	SWOG Cancer Research Network
Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors	NCT04771520	Anatomic Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Locally Advance... Locally Advance... Locally Advance... Locally Advance... Metastatic Mali... Metastatic Mela... Metastatic Prim... Metastatic Sarc... Pathologic Stag... Pathologic Stag... Pathologic Stag... Postneoadjuvant... Postneoadjuvant... Postneoadjuvant... Prognostic Stag... Prognostic Stag... Stage IIIC Colo... Stage IIIC Lung... Stage IV Colore... Stage IV Lung C... Stage IVA Color... Stage IVA Lung ... Stage IVB Color... Stage IVB Lung ... Stage IVC Color...	Avapritinib	18 Years -	M.D. Anderson Cancer Center
Testing the Addition of Radiation Therapy to Immunotherapy for Stage IV Non-Small Cell Lung Cancer Patients Who Are PD-L1 Negative	NCT04929041	Lung Adenocarci... Lung Adenosquam... Lung Non-Small ... Stage IIIB Lung... Stage IIIC Lung... Stage IV Lung C...	Biopsy Biospecimen Col... Computed Tomogr... Echocardiograph... Ipilimumab Magnetic Resona... Nivolumab Positron Emissi... Quality-of-Life... Stereotactic Bo...	18 Years -	National Cancer Institute (NCI)
Ramucirumab and Pembrolizumab for the Treatment of EGFR Mutant Recurrent or Metastatic Non-small Cell Lung Cancer	NCT04120454	Metastatic Lung... Recurrent Lung ... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Pembrolizumab Ramucirumab	18 Years -	Ohio State University Comprehensive Cancer Center
Microwave Ablation or Wedge Resection for the Treatment of Lung, Sarcoma and Colorectal Lesions, ALLUME Study	NCT04430725	Lung Non-Small ... Metastatic Colo... Metastatic Sarc... Stage I Lung Ca... Stage IA1 Lung ... Stage IA2 Lung ... Stage IA3 Lung ... Stage IB Lung C... Stage II Lung C... Stage IIA Lung ... Stage IIB Lung ... Stage III Lung ... Stage IIIA Lung... Stage IIIB Lung... Stage IIIC Lung... Stage IV Colore... Stage IV Lung C... Stage IVA Color... Stage IVA Lung ... Stage IVB Color... Stage IVB Lung ... Stage IVC Color...	Computed Tomogr... Microwave Ablat... Questionnaire A... Wedge Excision	18 Years -	M.D. Anderson Cancer Center
Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV	NCT04514484	Advanced Differ... Advanced Head a... Advanced Hepato... Advanced Kaposi... Advanced Lung N... Advanced Lung S... Advanced Malign... Advanced Melano... Advanced Ovaria... Advanced Prosta... Advanced Renal ... Advanced Thyroi... Advanced Triple... Advanced Urothe... Anatomic Stage ... Anatomic Stage ... Castration-Resi... Clinical Stage ... Clinical Stage ... HIV Infection Metastatic Diff... Metastatic Head... Metastatic Hepa... Metastatic Kapo... Metastatic Lung... Metastatic Lung... Metastatic Mali... Metastatic Mela... Metastatic Ovar... Metastatic Pros... Metastatic Rena... Metastatic Thyr... Metastatic Trip... Metastatic Urot... Recurrent Diffe... Recurrent Head ... Recurrent Hepat... Recurrent Kapos... Recurrent Lung ... Recurrent Lung ... Recurrent Malig... Recurrent Melan... Recurrent Ovari... Recurrent Prost... Recurrent Renal... Recurrent Thyro... Recurrent Tripl... Recurrent Uroth... Refractory Diff... Stage III Diffe... Stage III Hepat... Stage III Lung ... Stage III Ovari... Stage III Prost... Stage III Renal... Stage III Thyro... Stage IV Differ... Stage IV Hepato... Stage IV Lung C... Stage IV Ovaria... Stage IV Prosta... Stage IV Renal ... Stage IV Thyroi...	Biospecimen Col... Cabozantinib S-... Computed Tomogr... Magnetic Resona... Nivolumab	18 Years -	National Cancer Institute (NCI)
Decision Aid for the Improvement of Decision-Making in Patients With Non-small Cell Lung Cancer	NCT04946279	Lung Non-Small ... Stage I Lung Ca... Stage II Lung C... Stage III Lung ... Stage IV Lung C...	Best Practice Informational I... Questionnaire A...	-	OHSU Knight Cancer Institute
Telaglenastat Hydrochloride and Osimertinib in Treating Patients With EGFR-Mutated Stage IV Non-small Cell Lung Cancer	NCT03831932	Advanced Lung N... Metastatic Lung... Stage IV Lung C...	Biospecimen Col... Computed Tomogr... Magnetic Resona... Osimertinib Positron Emissi... Telaglenastat H... X-Ray Imaging	18 Years -	National Cancer Institute (NCI)
BeWell360-CG Care Model: Health and Wellness Coaching to Support Caregivers of Patients Living With Advanced Lung Cancers	NCT05640765	Advanced Lung C... Stage III Lung ... Stage IV Lung C...	Best Practice Educational Int... Health Promotio... Questionnaire A...	-	Mayo Clinic
Testing the Use of Targeted Treatment for RET Positive Advanced Non-small Cell Lung Cancer	NCT05364645	Lung Non-Small ... Recurrent Lung ... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Carboplatin Pemetrexed Selpercatinib	18 Years -	SWOG Cancer Research Network
Targeted Treatment for ALK Positive Patients Who Have Previously Been Treated for Non-squamous Non-small Cell Lung Cancer	NCT03737994	Lung Non-Squamo... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Alectinib Brigatinib Carboplatin Ceritinib Cisplatin Crizotinib Ensartinib Lorlatinib Pemetrexed	18 Years -	National Cancer Institute (NCI)
Testing the Addition of Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in People With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery	NCT04588246	Anatomic Stage ... Metastatic Brea... Metastatic Dige... Metastatic Lung... Metastatic Mali... Metastatic Mela... Metastatic Rena... Prognostic Stag... Recurrent Brain... Stage IV Lung C... Stage IV Renal ... Stage IVA Lung ... Stage IVB Lung ...	Memantine Quality-of-Life... Questionnaire A... Stereotactic Ra... Whole-Brain Rad...	18 Years -	NRG Oncology
Hypofractionated Radiation Therapy After Durvalumab and Chemotherapy for the Treatment of Stage IV Extensive Stage Small Cell Lung Cancer, CASPIAN-RT Trial	NCT05161533	Extensive Stage... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Carboplatin Cisplatin Durvalumab Etoposide Hypofractionate... Quality-of-Life... Questionnaire A...	18 Years -	University of Washington
Danvatirsen and Durvalumab in Treating Patients With Advanced and Refractory Pancreatic, Non-Small Cell Lung Cancer, and Mismatch Repair Deficient Colorectal Cancer	NCT02983578	Advanced Colore... Advanced Lung N... Lung Non-Small ... Mismatch Repair... Refractory Colo... Refractory Lung... Refractory Panc... Stage II Pancre... Stage III Color... Stage III Lung ... Stage III Pancr... Stage IIIA Colo... Stage IIIA Lung... Stage IIIB Colo... Stage IIIB Lung... Stage IIIC Colo... Stage IIIC Lung... Stage IV Colore... Stage IV Lung C... Stage IV Pancre... Stage IVA Color... Stage IVA Lung ... Stage IVB Color... Stage IVB Lung ... Stage IVC Color...	Danvatirsen Durvalumab	18 Years -	M.D. Anderson Cancer Center
An Interactive Time-Restricted Diet Intervention (txt4fasting) for Reducing Neurocognitive Decline and Improving Survival in Patients With Brain Metastases From Breast or Lung Cancer	NCT06315296	Anatomic Stage ... Metastatic Brea... Metastatic Lung... Metastatic Mali... Stage IV Lung C...	Behavioral Diet... Text Message-Ba... Internet-Based ... Dietary Counsel... Stereotactic Ra... Biospecimen Col... Magnetic Resona... Neurocognitive ... Questionnaire A... Interview Internet-Based ... Stereotactic Ra... Text Message-Ba... Biospecimen Col... Magnetic Resona... Neurocognitive ... Questionnaire A... Interview	18 Years -	Thomas Jefferson University
Resiliency Among Older Adults Receiving Lung Cancer Treatment	NCT04229381	Advanced Lung C... Extensive Stage... Stage IIIA Lung... Stage IIIB Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ... Unresectable Lu... Unresectable Lu...	Physical Therap... Quality-of-Life... Questionnaire A... Relaxation Ther...	60 Years -	Ohio State University Comprehensive Cancer Center
Conquer Fear SUPPORT Intervention in Supporting Patients With Stage III-IV Lung or Gynecologic Cancer	NCT03776253	Advanced Lung C... Malignant Femal... Stage III Lung ... Stage IIIA Lung... Stage IIIB Lung... Stage IIIC Lung... Stage IV Lung C...	Psychosocial Ca... Questionnaire A...	-	City of Hope Medical Center
Subcutaneous Atezolizumab for the Treatment of Non-small Cell Lung Cancer	NCT05340309	Lung Non-Small ... Stage II Lung C... Stage IIA Lung ... Stage IIB Lung ... Stage III Lung ... Stage IIIA Lung... Stage IIIB Lung... Stage IIIC Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Atezolizumab an... Survey Administ...	18 Years -	University of Southern California
Dyadic Yoga Intervention in Improving Physical Performance and Quality of Life in Patients With Stage I-IV Non-small Cell Lung or Esophageal Cancer Undergoing Radiotherapy and Their Caregivers	NCT03948100	Esophageal Carc... Lung Non-Small ... Stage I Lung Ca... Stage IA1 Lung ... Stage IA2 Lung ... Stage IA3 Lung ... Stage IB Lung C... Stage II Lung C... Stage IIA Lung ... Stage IIB Lung ... Stage III Lung ... Stage IIIA Lung... Stage IIIB Lung... Stage IIIC Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Educational Int... Quality-of-Life... Questionnaire A... Yoga	18 Years -	M.D. Anderson Cancer Center
Low-Dose Interleukin-2 and Pembrolizumab for the Treatment of Stage IV Non-Small Cell Lung Cancer	NCT05493566	Lung Non-Small ... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Aldesleukin Pembrolizumab	18 Years -	Emory University
Genetic Analysis of Blood and Tissue Samples From Patients With Advanced Cancer, Moonshot Study	NCT03707574	Advanced Malign... Advanced Melano... Advanced Renal ... Anatomic Stage ... Anatomic Stage ... Anatomic Stage ... Anatomic Stage ... Anatomic Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Prognostic Stag... Prognostic Stag... Prognostic Stag... Prognostic Stag... Prognostic Stag... Stage III Color... Stage III Lung ... Stage III Ovari... Stage III Prost... Stage IIIA Colo... Stage IIIA Lung... Stage IIIA Ovar... Stage IIIA Pros... Stage IIIA1 Ova... Stage IIIA2 Ova... Stage IIIB Colo... Stage IIIB Lung... Stage IIIB Ovar... Stage IIIB Pros... Stage IIIC Colo... Stage IIIC Lung... Stage IIIC Ovar... Stage IIIC Pros... Stage IV Colore... Stage IV Lung C... Stage IV Ovaria... Stage IV Prosta... Stage IVA Color... Stage IVA Lung ... Stage IVA Ovari... Stage IVA Prost... Stage IVB Color... Stage IVB Lung ... Stage IVB Ovari... Stage IVB Prost... Stage IVC Color...	Biospecimen Col...	18 Years -	National Cancer Institute (NCI)
Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity KRASG12V Mutation-Specific T Cell Receptors (FH-A11KRASG12V-TCR) in Treating Patients With Metastatic Pancreatic, Colorectal and Non-Small Cell Lung Cancers With KRAS G12V Mutations	NCT06043713	Metastatic Colo... Metastatic Lung... Metastatic Panc... Stage IV Colore... Stage IV Lung C... Stage IV Pancre...	Bendamustine Biopsy Biospecimen Col... Computed Tomogr... Cyclophosphamid... Echocardiograph... Fludarabine Leukapheresis Magnetic Resona... Multigated Acqu... Positron Emissi... T-cell Receptor...	18 Years -	Fred Hutchinson Cancer Center
PBF-1129 and Nivolumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer	NCT05234307	Metastatic Lung... Recurrent Lung ... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Adenosine A2B R... Biospecimen Col... Nivolumab	18 Years -	Ohio State University Comprehensive Cancer Center
Local Consolidative Therapy and Brigatinib in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer	NCT03707938	Advanced Lung C... ALK Gene Rearra... Lung Non-Small ... Recurrent Lung ... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Brigatinib Local Consolida...	18 Years -	M.D. Anderson Cancer Center
Osimertinib in Combination With Alisertib or Sapanisertib for the Treatment of Osimertinib-Resistant EGFR Mutant Stage IIIB or IV Non-Small Cell Lung Cancer	NCT04479306	Recurrent Lung ... Stage IIIB Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Alisertib Osimertinib Sapanisertib	18 Years -	M.D. Anderson Cancer Center
Atezolizumab and Cobimetinib in Treating Patients With Metastatic, Recurrent, or Refractory Non-small Cell Lung Cancer	NCT03600701	Metastatic Lung... Recurrent Lung ... Refractory Lung... Stage IV Lung C...	Atezolizumab Biopsy Biospecimen Col... Cobimetinib Computed Tomogr... Magnetic Resona...	18 Years -	National Cancer Institute (NCI)
Geriatric and Quality of Life Assessments in Older Patients With Non-metastatic or Metastatic Head and Neck or Lung Cancer Undergoing Surgery or Chemoradiation and Their Caregivers	NCT03902535	Caregiver Head and Neck C... Lung Carcinoma Metastatic Head... Metastatic Lung... Stage 0 Lung Ca... Stage I Lung Ca... Stage IA1 Lung ... Stage IA2 Lung ... Stage IA3 Lung ... Stage IB Lung C... Stage II Lung C... Stage IIA Lung ... Stage IIB Lung ... Stage III Lung ... Stage IIIA Lung... Stage IIIB Lung... Stage IIIC Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Comprehensive G... Quality-of-Life... Questionnaire A...	21 Years -	City of Hope Medical Center
Local Consolidative Therapy and Brigatinib in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer	NCT03707938	Advanced Lung C... ALK Gene Rearra... Lung Non-Small ... Recurrent Lung ... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Brigatinib Local Consolida...	18 Years -	M.D. Anderson Cancer Center
Osimertinib With or Without Bevacizumab in Treating Patients With EGFR Positive Non-small Cell Lung Cancer and Brain Metastases	NCT02971501	Metastatic Lung... Metastatic Mali... Stage IV Lung C...	Bevacizumab Biopsy Biospecimen Col... Computed Tomogr... Magnetic Resona... Osimertinib	18 Years -	National Cancer Institute (NCI)
Remote Monitoring With Health-Coaching for Lifestyle Changes in Patients With Lung Cancer Related Fatigue	NCT05407038	Advanced Lung N... Stage III Lung ... Stage IIIA Lung... Stage IIIB Lung... Stage IIIC Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Exercise Counse... Exercise Interv... Internet-Based ... Interview Medical Device ... Questionnaire A...	18 Years -	Mayo Clinic
Temozolomide and Atezolizumab as Second or Third Line for the Treatment of Metastatic or Recurrent Small Cell Lung Cancer	NCT04919382	Extensive Stage... Metastatic Lung... Recurrent Lung ... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Atezolizumab Temozolomide	18 Years -	Big Ten Cancer Research Consortium
Testing the Safety of M6620 (VX-970) When Given With Standard Whole Brain Radiation Therapy for the Treatment of Brain Metastases From Non-small Cell Lung Cancer, Small Cell Lung Cancer, or Neuroendocrine Tumors	NCT02589522	Metastatic Lung... Metastatic Lung... Metastatic Lung... Metastatic Mali... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Berzosertib Quality-of-Life... Therapeutic Con... Whole-Brain Rad...	18 Years -	National Cancer Institute (NCI)
Osimertinib, Cetuximab, and Tucatinib for the Treatment of EGFR-Mutant Stage IV or Recurrent Non-small Lung Cell Cancer	NCT06067776	Metastatic Lung... Recurrent Lung ... Stage IV Lung C...	Cetuximab Osimertinib Tucatinib	18 Years -	University of California, Davis
CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors	NCT05733000	Advanced Biliar... Advanced Colore... Advanced Gastro... Advanced Lung A... Advanced Malign... Advanced Ovaria... Advanced Pancre... Advanced Urothe... Clinical Stage ... Clinical Stage ... Metastatic Bili... Metastatic Colo... Metastatic Gast... Metastatic Lung... Metastatic Ovar... Metastatic Panc... Metastatic Urot... Refractory Bili... Refractory Colo... Refractory Gast... Refractory Lung... Refractory Ovar... Refractory Panc... Refractory Urot... Stage II Pancre... Stage III Color... Stage III Lung ... Stage III Ovari... Stage III Pancr... Stage IV Colore... Stage IV Lung C... Stage IV Ovaria... Stage IV Pancre...	Biospecimen Col... Computed Tomogr... Devimistat Fluorouracil Gemcitabine Hyd... Hydroxychloroqu... Magnetic Resona...	18 Years -	Northwestern University
Stereotactic Radiosurgery for the Treatment of Patients With Small Cell Lung Cancer Brain Metastasis	NCT04516070	Metastatic Lung... Metastatic Mali... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Questionnaire A... Stereotactic Ra...	18 Years -	M.D. Anderson Cancer Center
Phase 2 DoceRamPem for Patients With Metastatic or Recurrent NSCLC Who Progressed on Platinum-Doublet and PD-1/PD-L1 Blockade	NCT04340882	Metastatic Non-... Recurrent Non-S... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Docetaxel Pembrolizumab Ramucirumab	18 Years -	Emory University
Cemiplimab for the Treatment of Untreated Brain Metastases From PD-L1 >= 50% Non-Small Cell Lung Cancer	NCT05840770	Metastatic Lung... Metastatic Mali... Stage IV Lung C...	Biospecimen Col... Cemiplimab Computed Tomogr... Magnetic Resona... Positron Emissi...	18 Years -	City of Hope Medical Center
Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)	NCT06031688	Recurrent Lung ... Stage IV Lung C...	Biospecimen Col... Computed Tomogr... Lymphoscintigra... Magnetic Resona... Ramucirumab Tepotinib	-	SWOG Cancer Research Network
National Cancer Institute "Cancer Moonshot Biobank"	NCT04314401	Acute Myeloid L... Anatomic Stage ... Anatomic Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Lung Non-Small ... Lung Small Cell... Malignant Solid... Metastatic Pros... Multiple Myelom... Stage III Lung ... Stage III Ovari... Stage IV Colore... Stage IV Lung C... Stage IV Ovaria... Stage IV Prosta... Stage IVB Prost...	Biospecimen Col... Medical Chart R...	13 Years -	National Cancer Institute (NCI)
Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)	NCT05642572	Recurrent Lung ... Stage IV Lung C...	Biospecimen Col... Capmatinib Computed Tomogr... Magnetic Resona... Osimertinib Ramucirumab	18 Years -	SWOG Cancer Research Network
Tumor Treating Fields (TTFields) Therapy to Manage Brain Metastases in Small Cell Lung Cancer	NCT03995667	Extensive Stage... Limited Stage L... Stage I Lung Ca... Stage IA1 Lung ... Stage IA2 Lung ... Stage IA3 Lung ... Stage IB Lung C... Stage II Lung C... Stage IIA Lung ... Stage IIB Lung ... Stage III Lung ... Stage IIIA Lung... Stage IIIB Lung... Stage IIIC Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Questionnaire A... Tumor Treating ...	22 Years -	OHSU Knight Cancer Institute
Genetically Engineered Natural Killer (NK) Cells With or Without Atezolizumab for the Treatment of Non-small Cell Lung Cancer Previously Treated With PD-1 and/or PD-L1 Immune Checkpoint Inhibitors	NCT05334329	Advanced Lung N... Metastatic Lung... Recurrent Lung ... Refractory Lung... Stage III Lung ... Stage IIIA Lung... Stage IIIB Lung... Stage IIIC Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Antineoplastic ... Atezolizumab Biospecimen Col... Cyclophosphamid... Fludarabine	18 Years -	City of Hope Medical Center
Cemiplimab for the Treatment of Untreated Brain Metastases From PD-L1 >= 50% Non-Small Cell Lung Cancer	NCT05840770	Metastatic Lung... Metastatic Mali... Stage IV Lung C...	Biospecimen Col... Cemiplimab Computed Tomogr... Magnetic Resona... Positron Emissi...	18 Years -	City of Hope Medical Center
4D PET/CT in Diagnosing Participants With Lung and Colorectal Cancer With Liver and Lung Metastasis	NCT00862680	Metastatic Mali... Metastatic Mali... Stage IV Colore... Stage IV Lung C... Stage IVA Color... Stage IVA Lung ... Stage IVB Color... Stage IVB Lung ... Stage IVC Color...	4-Dimensional C... 4D PET Scan	18 Years -	M.D. Anderson Cancer Center
Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer	NCT03793179	Lung Non-Squamo... Stage IIIB Lung... Stage IIIC Lung... Stage IV Lung C...	Biospecimen Col... Carboplatin Computed Tomogr... Magnetic Resona... Pembrolizumab Pemetrexed Positron Emissi...	18 Years -	National Cancer Institute (NCI)
Testing the Addition of Radiation Therapy to Immunotherapy for Stage IV Non-Small Cell Lung Cancer Patients Who Are PD-L1 Negative	NCT04929041	Lung Adenocarci... Lung Adenosquam... Lung Non-Small ... Stage IIIB Lung... Stage IIIC Lung... Stage IV Lung C...	Biopsy Biospecimen Col... Computed Tomogr... Echocardiograph... Ipilimumab Magnetic Resona... Nivolumab Positron Emissi... Quality-of-Life... Stereotactic Bo...	18 Years -	National Cancer Institute (NCI)
Sonidegib and Pembrolizumab in Treating Patients With Advanced Solid Tumors	NCT04007744	Clinical Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Locally Advance... Locally Advance... Locally Advance... Metastatic Gast... Metastatic Gast... Metastatic Head... Metastatic Lung... Metastatic Mali... Metastatic Mela... Metastatic Urot... Recurrent Head ... Refractory Lung... Stage IV Cutane... Stage IV Lung C... Unresectable Ma... Unresectable Me...	Pembrolizumab Sonidegib	18 Years -	Mayo Clinic
National Cancer Institute "Cancer Moonshot Biobank"	NCT04314401	Acute Myeloid L... Anatomic Stage ... Anatomic Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Lung Non-Small ... Lung Small Cell... Malignant Solid... Metastatic Pros... Multiple Myelom... Stage III Lung ... Stage III Ovari... Stage IV Colore... Stage IV Lung C... Stage IV Ovaria... Stage IV Prosta... Stage IVB Prost...	Biospecimen Col... Medical Chart R...	13 Years -	National Cancer Institute (NCI)
Tumor Treating Fields (TTFields) Therapy to Manage Brain Metastases in Small Cell Lung Cancer	NCT03995667	Extensive Stage... Limited Stage L... Stage I Lung Ca... Stage IA1 Lung ... Stage IA2 Lung ... Stage IA3 Lung ... Stage IB Lung C... Stage II Lung C... Stage IIA Lung ... Stage IIB Lung ... Stage III Lung ... Stage IIIA Lung... Stage IIIB Lung... Stage IIIC Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Questionnaire A... Tumor Treating ...	22 Years -	OHSU Knight Cancer Institute
A Biobehavioral/Cognitive Treatment for Stress, Depression, and Anxiety in Patients With Stage IV Lung Cancer	NCT05342571	Advanced Lung C... Metastatic Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Behavioral, Psy... Biospecimen Col... Electronic Heal... Informational I... Survey Administ...	18 Years -	Ohio State University Comprehensive Cancer Center
Bintrafusp Alfa With Chemotherapy for Tyrosine Kinase Inhibitor-Resistant EGFR-Mutant Non-small Cell Lung Cancer	NCT04971187	Locally Advance... Metastatic Lung... Stage III Lung ... Stage IIIA Lung... Stage IIIB Lung... Stage IIIC Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ... Unresectable Lu...	Bintrafusp Alfa Pemetrexed Carboplatin Cisplatin	18 Years -	M.D. Anderson Cancer Center
PET/CT Changes During Chemoimmunotherapy and Radiation Therapy in Patients With Stage IV Non-small Cell Lung Cancer	NCT04151940	Metastatic Lung... Recurrent Lung ... Stage IV Lung C...	Positron Emissi... Computed Tomogr... Chemotherapy Immunotherapy Radiation Thera...	18 Years -	University of Washington
Testing the Addition of an Experimental Medication MK-3475 (Pembrolizumab) to Usual Anti-Retroviral Medications in Patients With HIV and Cancer	NCT02595866	AIDS-Related No... Clinical Stage ... Clinical Stage ... Hepatocellular ... HIV Infection Kaposi Sarcoma Locally Advance... Locally Advance... Metastatic Lung... Metastatic Mali... Metastatic Mela... Non-Hodgkin Lym... Recurrent Class... Recurrent Malig... Refractory Clas... Refractory Mali... Stage III Lung ... Stage IV Lung C... Unresectable Me...	Antiretroviral ... Biopsy Biospecimen Col... Computed Tomogr... Pembrolizumab Positron Emissi...	18 Years -	National Cancer Institute (NCI)
A Tool for Improving the Shared Decision-making Process in Patients With Non-small Cell Lung Cancer	NCT06122064	Lung Non-Small ... Stage II Lung C... Stage III Lung ... Stage IV Lung C...	Best Practice Communication I... Electronic Heal... Survey Administ... Video Recording	18 Years -	Mayo Clinic
Brigatinib and Bevacizumab for the Treatment of ALK-Rearranged Locally Advanced, Metastatic, or Recurrent NSCLC	NCT04227028	Locally Advance... Metastatic Lung... Recurrent Lung ... Stage III Lung ... Stage IIIA Lung... Stage IIIB Lung... Stage IIIC Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Bevacizumab Brigatinib	18 Years -	City of Hope Medical Center
Role of Gut Microbiome and Fecal Transplant on Medication-Induced GI Complications in Patients With Cancer	NCT03819296	Clinical Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Colitis Lung Non-Small ... Malignant Genit... Malignant Solid... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Stage 0 Lung Ca... Stage I Lung Ca... Stage IA1 Lung ... Stage IA2 Lung ... Stage IA3 Lung ... Stage IB Lung C... Stage II Lung C... Stage IIA Lung ... Stage IIB Lung ... Stage III Lung ... Stage IIIA Lung... Stage IIIB Lung... Stage IIIC Lung... Stage IV Lung C... Stage IVA Lung ... Stage IVB Lung ...	Best Practice Biospecimen Col... Endoscopic Proc... Fecal Microbiot... Infliximab Laboratory Biom... Prednisone Vedolizumab	18 Years -	M.D. Anderson Cancer Center

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