Spots Global Cancer Trial Database for Study of Selumetinib (AZD6244)(ARRY-142886) in Combination With Irinotecan in Previously Treated Patients With Colorec
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Trial Identification
Brief Title: Study of Selumetinib (AZD6244)(ARRY-142886) in Combination With Irinotecan in Previously Treated Patients With Colorec
Official Title: A Dose Finding and Phase II Study of Selumetinib (AZD6244) (Hyd-Sulfate) in Combination With Irinotecan, in 2nd Line Patients With K-ras or B-raf Mutation Positive Advanced or Metastatic Colorectal Cancer
Study ID: NCT01116271
Conditions
Study Description
Brief Summary: The purpose of this study is to determine whether treatment with Selumetinib (AZD6244) (Hyd-Sulfate) in combination with Irinotecan as a second treatment in patients with K-ras or B-raf mutation will prevent tumor progression and prolong progression free survival.
Detailed Description: A Dose Finding and Phase II Study of Selumetinib (AZD6244) (Hyd-Sulfate) in Combination with Irinotecan, in 2nd Line Patients with K-ras or B-raf Mutation Positive Advanced or Metastatic Colorectal Cancer
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Research Site, Los Angeles, California, United States
Research Site, Palm Springs, California, United States
Research Site, Aurora, Colorado, United States
Research Site, New Haven, Connecticut, United States
Research Site, Newark, Delaware, United States
Research Site, Miami Beach, Florida, United States
Research Site, New York, New York, United States
Reserach Site, Chapel Hill, North Carolina, United States
Research Site, Greenville, North Carolina, United States
Research Site, Washington, North Carolina, United States
Research Site, Philadelphia, Pennsylvania, United States
Research Site, Seattle, Washington, United States
Contact Details
Name: Howard Hochster, MD
Affiliation: Yale University
Role: PRINCIPAL_INVESTIGATOR
Name: Lawrence Leichman, MD
Affiliation: Desert Regional Comprehensive Cancer Center
Role: PRINCIPAL_INVESTIGATOR
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