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Spots Global Cancer Trial Database for Recombinant Vaccinia Virus Administered Intravenously in Patients With Metastatic, Refractory Colorectal Carcinoma

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Recombinant Vaccinia Virus Administered Intravenously in Patients With Metastatic, Refractory Colorectal Carcinoma

Official Title: A Phase 1/2a Dose-escalation Study of JX 594 Administered by Multiple Intravenous (IV) Infusions Alone and in Combination With Irinotecan in Patients With Metastatic, Refractory Colorectal Carcinoma.

Study ID: NCT01394939

Interventions

JX-594
Irinotecan

Study Description

Brief Summary: The purpose of this study is to evaluate the safety, tolerability, and efficacy of JX-594 (Pexa-Vec) administered intravenously either alone or in combination with Irinotecan in colorectal carcinoma patients who are refractory to or intolerant to standard therapy.

Detailed Description: This was a Phase 1/2a, open-label, dose-escalation study in patients with advanced colorectal cancer (CRC)

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Mayo Clinic, Scottsdale, Arizona, United States

UCSD Moores Cancer Center, La Jolla, California, United States

Billings Clinic Cancer Center, Billings, Montana, United States

University of North Carolina, Chapel Hill, North Carolina, United States

Gabrail Cancer Center, Canton, Ohio, United States

The Ohio State University, Columbus, Ohio, United States

Juravinski Cancer Centre, Hamilton, Ontario, Canada

Ottawa Hospital and Research Institute (OHRI), Ottawa, Ontario, Canada

Hôpital Saint Antoine, Paris, , France

Hôpital Hautepierre, Strasbourg, , France

Institut Claudius Regaud, Toulouse, , France

Contact Details

Name: James Burke, MD

Affiliation: Jennerex Biotherapeutics

Role: STUDY_DIRECTOR

Name: Derek Jonker, MD

Affiliation: Ottawa Hospital and Research Institute

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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