Spots Global Cancer Trial Database for Metastatic Colorectal Cancer: Treatment Response With Dynamic Contrast MRI

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Trial Identification

Brief Title: Metastatic Colorectal Cancer: Treatment Response With Dynamic Contrast MRI

Official Title: Angle Interleaved Projection Reconstruction With K-Space Weighted Image Reconstruction for Dynamic Contrast MRI of Cancer Therapy Response

Study ID: NCT00820456

Conditions

Colorectal Neoplasm

Hepatic Neoplasm

Interventions

DCE-MRI

Study Description

Brief Summary: The objectives for this study include: * Testing a unique way of imaging people with colorectal cancer and other cancers that has spread to the liver using magnetic resonance imaging (MRI); * Seeing if the MRI process can be used across multiple imaging platforms; * Determining whether the results of the imaging can be reproduced; * Reviewing how MRI results relate to cancer response to combination therapy and to clinical endpoints.

Detailed Description: This study will investigate the use of projection reconstruction dynamic contrast-enhanced MRI (DCE-MRI) as a surrogate marker of tumor vascularity in patients treated with the antiangiogenic agent bevacizumab. DCE-MRI is gaining popularity as a method to assess the functional response of tumors to agents targeting the vascular endothelial growth factor (VGEF) pathways. DCE-MRI measurements have been proposed as a non-invasive measure of both tumor biologic activity and (in the case of antivascular therapy) early response to treatment. A number of phase I and II studies demonstrate the ability for DCE-MRI to detect perfusion changes associated with tumor biologic response to vascularly targeted agents. It has been suggested that pre-treatment DCE-MRI might identify tumors with high intrinsic perfusion and that these tumors will be more likely to respond to antivascular-based therapies. However, the current use of DCE-MRI in clinical settings is challenging. Trade-offs between spatial coverage, time, and spatial resolution make this technique difficult to implement in human studies and may limit its reliability. The use of projection reconstruction-based acquisition can mitigate the need for these trade-offs and can simultaneously provide high temporal and spatial resolution data for DCE-MRI analysis.