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Spots Global Cancer Trial Database for Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tumors Harboring Activating FGFR1-3 Alterations

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Trial Identification

Brief Title: Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tumors Harboring Activating FGFR1-3 Alterations

Official Title: A Phase 2, Open-Label, Single-Arm, Multicenter Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tumors Harboring Activating FGFR1-3 Alterations (FIGHT-209)

Study ID: NCT05267106

Interventions

Pemigatinib

Study Description

Brief Summary: This is an open-label, monotherapy study of pemigatinib in participants with recurrent glioblastoma (GBM) or other recurrent gliomas, circumscribed astrocytic gliomas, and glioneuronal and neuronal tumors with an activating FGFR1-3 mutation or fusion/rearrangement. This study consists of 2 cohorts, Cohorts A, and B, and will enroll approximately 82 participants into each cohort. Participants will receive pemigatinib 13.5 mg QD on a 2-week on-therapy and 1-week off-therapy schedule as long as they are receiving benefit and have not met any criteria for study withdrawal.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Valkyrie Clinical Trials, Beverly Hills, California, United States

City of Hope National Medical Center, Duarte, California, United States

Providence Medical Foundation, Fullerton, California, United States

Usc Norris Comprehensive Cancer Center, Los Angeles, California, United States

Stanford Neuroscience Health Center, Sacramento, California, United States

Sharp Memorial Hospital, San Diego, California, United States

University of California San Francisco, San Francisco, California, United States

Providence St Joseph Hospital Orange Center For Cancer Prevention and Treatment, Santa Monica, California, United States

Yale Cancer Center, New Haven, Connecticut, United States

Baptist Md Anderson Cancer Center, Jacksonville, Florida, United States

Miami Cancer Institute, Miami, Florida, United States

Orlando Health Cancer Institute Downtown Orlando, Orlando, Florida, United States

H. Lee Moffitt Cancer Center and Research Institute Hospital, Tampa, Florida, United States

University of Illinois Hospital & Health Sciences System, Chicago, Illinois, United States

University of Iowa Hospital and Clinics, Iowa City, Iowa, United States

University Medical Center New Orleans, New Orleans, Louisiana, United States

University of Minnesota Health Clinics and Surgery Center, Minneapolis, Minnesota, United States

Northwell Health, Lake Success, New York, United States

Columbia University Irving Medical Center, New York, New York, United States

Memorial Sloan Kettering Cancer Center, New York, New York, United States

East Carolina University, Greenville, North Carolina, United States

Wake Forest Baptist Health, Winston-Salem, North Carolina, United States

UC Health At Cincinnati Va Medical Center, Cincinnati, Ohio, United States

Cleveland Clinic Foundation, Cleveland, Ohio, United States

University of Pennsylvania Hospital, Philadelphia, Pennsylvania, United States

University of Pittsburgh Medical Center Health System, Pittsburgh, Pennsylvania, United States

Tennessee Oncology, Chattanooga, Tennessee, United States

Tennessee Oncology, Nashville, Tennessee, United States

Baylor University Medical Center, Dallas, Texas, United States

Houston Methodist Hospital, Houston, Texas, United States

Huntsman Cancer Institute, Salt Lake City, Utah, United States

Fred Hutchinson Cancer Research Center, Seattle, Washington, United States

Aalborg Universitets Hospital, Aalborg, , Denmark

Rigshospitalet Uni of Hospital of Copenhagen, Copenhagen, , Denmark

Odense University Hospital, Odense C, , Denmark

Chru de Lille Hopital Claude Huriez, Lille Cedex, , France

Chu Hopital de La Timone, Marseille, , France

Hospital Universitaire Pitie-Salpetriere, Paris, , France

Universitaire Du Cancer de Toulouse Institut Claudius Regaud Iuct-Oncopole, Toulouse, , France

Universitatsklinikum Bonn Aoer, Bonn, , Germany

Klinikum Der Johann Wolfgang Goethe University, Frankfurt, , Germany

Universitaetsklinikum Heidelberg, Heidelberg, , Germany

University Hospital Tuebingen, Tuebingen, , Germany

Ospedale Bellaria, Bologna, , Italy

Istituto Di Ricovero E Cura A Carattere Scientifico (Irccs) Ospedale San Raffaele, Milano, , Italy

Iov - Istituto Oncologico Veneto Irccs, Padova, , Italy

A.S.L. Napoli 1 Centro Ospedale Del Mare, Ponticelli, , Italy

Irccs Istituto Clinico Humanitas, Rozzano, , Italy

Azienda Ospedaliero Universitaria Citta Della Salute E Della Scienza, Torino, , Italy

University of Tokyo Hospital, Bunkyo-ku, , Japan

National Cancer Center Hospital, Chuo-ku, , Japan

Kyushu University Hospital, Fukuoka-shi, , Japan

Kyoto University Hospital, Kyoto-shi, , Japan

Nagoya University Hospital, Nagoya-shi, , Japan

Tohoku University Hospital, Sendai-shi, , Japan

Netherlands Cancer Institute Antoni Van Leeuwenhoek Ziekenhuis, Amsterdam, , Netherlands

Erasmus Mc Cancer Institute, Rotterdam, , Netherlands

Hospital Del Mar, Barcelona, , Spain

Hospital General Universitario Vall D Hebron, Barcelona, , Spain

Hospital Clinic Barcelona Main, Barcelona, , Spain

Hospital de La Santa Creu I Sant Pau, Barcelona, , Spain

Ico Girona Hospital Universitari de Girona Dr Josep Trueta, Girona, , Spain

Ico Institut Catala D Oncologia, L'hospitalet de Llobregat, , Spain

Hospital General Universitario Gregorio Maranon, Madrid, , Spain

Hospital Universitario Ramon Y Cajal, Madrid, , Spain

Hospital Universitario 12 de Octubre, Madrid, , Spain

Hospital Universitario Hm Sanchinarro, Madrid, , Spain

Clinica Universidad de Navarra (Cun), Pamplona, , Spain

Hospital General de Catalunya, Sant Cugat Del Valles, , Spain

Hospital Universitario Virgen Del Rocio, Sevilla, , Spain

Hospital General Universitario de Valencia, Valencia, , Spain

Addenbrooke'S Hospital, Cambridge, , United Kingdom

Velindre Cancer Centre, Cardiff, , United Kingdom

St James'S University Hospital, Leeds, , United Kingdom

Guys Hospital, London, , United Kingdom

The Royal Marsden Nhs Foundation Trust - Sutton, London, , United Kingdom

The Royal Marsden Nhs Foundation Trust - Chelsea, London, , United Kingdom

The Christie Nhs Foundation Trust Uk, Manchester, , United Kingdom

The Clatterbridge Cancer Centre, Wirral, , United Kingdom

Contact Details

Name: Victoria Ebiana, MD

Affiliation: Incyte Corporation

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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