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Spots Global Cancer Trial Database for Glioblastoma Treatment With Irradiation and Olaptesed Pegol (NOX-A12) in MGMT Unmethylated Patients

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Trial Identification

Brief Title: Glioblastoma Treatment With Irradiation and Olaptesed Pegol (NOX-A12) in MGMT Unmethylated Patients

Official Title: Single-arm Dose-escalation Phase 1/2 Study of Olaptesed Pegol (NOX-A12) in Combination With Irradiation in Inoperable or Partially Resected First-line Glioblastoma Patients With Unmethylated MGMT Promoter With a 3-arm Expansion Group Including Fully Resected Patients and Combination With Bevacizumab or Pembrolizumab

Study ID: NCT04121455

Conditions

Glioblastoma

Study Description

Brief Summary: The purpose of this study is to obtain first, exploratory information on the safety and efficacy of (i) olaptesed pegol in combination with radiation therapy in patients with newly diagnosed glioblastoma of unmethylated MGMT promoter status either not amenable to resection (biopsy only) or after incomplete tumor resection, (ii) olaptesed pegol in combination with radiation therapy and bevacizumab in patients with newly diagnosed glioblastoma of unmethylated MGMT promoter status either not amenable to resection (biopsy only) or after incomplete or complete tumor resection, (iii) olaptesed pegol in combination with radiation therapy in patients with newly diagnosed glioblastoma of unmethylated MGMT promoter status after complete tumor resection, and (iv) olaptesed pegol in combination with radiation therapy and pembrolizumab in patients with newly diagnosed glioblastoma of unmethylated MGMT promoter status after either complete or incomplete tumor resection.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Klinik und Poliklinik für Neurologie Schwerpunkt Klinische Neuroonkologie, Bonn, , Germany

Klinik für Neurologie, Essen, , Germany

Klinik für Strahlentherapie und Radioonkologie, Leipzig, , Germany

Klinik für Strahlentherapie und Radioonkologie, Mannheim, , Germany

Klinik für Neurologie mit Institut für Translationale Neurologie, Münster, , Germany

Abteilung Neurologie mit interdisziplinärem Schwerpunkt Neuroonkologie, Tübingen, , Germany

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

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