Spots Global Cancer Trial Database for Hemostasis Alterations in Neurosurgical Patients

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Trial Identification

Brief Title: Hemostasis Alterations in Neurosurgical Patients

Official Title: Prospective Study on Hemostasis Alterations in Patients Undergoing Neuro Surgical Glioma Resection Acronym: (ABCD Study: Acute Brain Coagulopathy Development Study)

Study ID: NCT02652897

Conditions

Glioma

Coagulopathy

Acquired Platelet Function Disorder

Thromboelastometry

Surgery

Interventions

Exposure to glioma resection surgery

Exposure to colon resection surgery

Study Description

Brief Summary: Prospective, observational study aimed to investigate the specific hemostatic alterations in patients undergoing glial tumor resection.

Detailed Description: Brain parenchyma express tissue factor and other coagulation factors in high concentrations. In addition, neuro critical patients (NCP) may present platelet dysfunction, hyperfibrinolysis, hypo coagulation and / or hyper coagulation status, early after the injury. It is not known whether these alterations of hemostasis are due to a specific brain response to aggression, or they are included into a systemic response. This prospective, observational study is aimed to investigate the coagulation disorders specifically associated with cerebral aggression. This is a prospective, cohort study including (calculated sample size) a study group of patients undergoing elective surgery (glial tumors) and other one undergoing colo rectal surgery. Alterations of the hemostasis will be evaluated by clotting tests, thromboelastometry and tests for platelet function. Samples will be drawn before and after surgical procedures. Multiple statistical comparisons intra and inter groups will be performed.