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Brief Title: Analysis of Patterns of Recurrence in Head and Neck Cancer Using Clinicopathomic Markers
Official Title: Analysis of Patterns of Recurrence in Head and Neck Cancer Using Clinicopathomic Markers
Study ID: NCT04086849
Brief Summary: Here, the investigators will develop a clinicopathomic assay from biomarkers obtained from digital pathologies of resected whole-mount oral cavity and oropharyngeal squamous cell carcinoma (OCSCC and OPSCC) specimens with the goal of administering personalized novel image-guided therapies immediately after primary surgical management in OCSCC and OPSCC patients. The primary aim is to determine the association between clinicopathomic biomarkers and LRR. The secondary aim is to develop a clinicopathomic risk score (assay) such that a decision-support tool can be used by physicians for measuring the benefit of additional therapies (i.e. conventional chemotherapy +/- radiation or administering dose-escalated chemoradiation) in the adjuvant setting to reduce LRR rates.
Detailed Description: The proposed study is significant for developing personalized treatments. The proposed research will yield high rewards to patients by providing additional information to clinicians for better prognostication and potentially adapting adjuvant treatments to improve the survival of patients with OCSCC or OPSCC.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Name: William Tran, MRT(T), PhD
Affiliation: Sunnybrook Research Institute
Role: PRINCIPAL_INVESTIGATOR