Spots Global Cancer Trial Database for Uniform FDG-PET Guided Gradient Dose Prescription to Reduce Late Radiation Toxicity
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Trial Identification
Brief Title: Uniform FDG-PET Guided Gradient Dose Prescription to Reduce Late Radiation Toxicity
Official Title: Uniform FDG-PET Guided GRAdient Dose prEscription to Reduce Late Radiation Toxicity (UPGRADE-RT): a Randomised Controlled Trial With Dose Reduction to the Elective Neck in Head and Neck Squamous Cell Carcinoma
Study ID: NCT02442375
Study Description
Brief Summary: The objective of the UPGRADE-RT trial is to investigate whether de-escalation of elective radiation dose and introduction of an intermediate dose-level in the treatment of head and neck cancer will results in less radiation sequelae and improved quality of life after treatment whilst the recurrence rate in electively irradiated lymph nodes should not be compromised. A summary of the study protocol can be found here: http://rdcu.be/qgMv
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
VU University Medical Center Amsterdam, Amsterdam, , Netherlands
Radiotherapiegroep, Arnhem, Arnhem, , Netherlands
MAASTRO clinic, Maastricht, Maastricht, , Netherlands
Radboud University Nijmegen Medical Center, Nijmegen, , Netherlands
University Medical Center Utrecht, Utrecht, , Netherlands
Contact Details
Name: Prof. Dr. J.H.A.M. Kaanders
Affiliation: Radboud University Nijmegen Medical Center
Role: STUDY_CHAIR
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