Spots Global Cancer Trial Database for Screening for HPV and Cervical Cancer in Young Women With Perinatally Acquired HIV

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Screening for HPV and Cervical Cancer in Young Women With Perinatally Acquired HIV

Official Title: Screening for Human Papillomavirus and Cervical Cancer in Young Women With Perinatally Acquired HIV

Study ID: NCT04587050

Conditions

HIV Infections

Human Papillomavirus Infection

Cervical Cancer

Interventions

Human papillomavirus testing

Cervical cytology

HPV serology

Study Description

Brief Summary: This is a cross-sectional, observational study of high-risk HPV status, cervical cytology and HPV vaccine uptake and response in young women with perinatally acquired HIV.

Detailed Description: This is an observational study of cervical cytology assessment, high risk human papilloma virus (hr-HPV) status, and HPV antibody titres amongst adult women living with perinatally acquired HIV infection (PaHIV). Eligible consenting participants will have two samples taken; firstly, a cervical sample tested for cytology and Hr-HPV with the Cepheid GeneXpert HPV; secondly serum will be assessed for hr-HPV serology. All women with PaHIV, vaccinated and unvaccinated for HPV, over the age of 18 years will be eligible and will be recruited into one of two cohorts: (1) sexually active women: full study, cervical and blood sampling (n=50) or (2) non-sexually active women, blood sampling only (n=30). Follow up for abnormal smear results or hr-HPV positivity will be arranged through colposcopy.