Infections

All Conditions

Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Symptoms and General Pathology

Immune System Diseases

Uterine Cervical Neoplasms

Communicable Diseases

Acquired Immunodeficiency Syndrome

HIV Infections

Papillomavirus Infections

Disease Attributes

Sexually Transmitted Diseases

Sexually Transmitted Diseases, Viral

Virus Diseases

Genital Diseases

Urogenital Diseases

Uterine Neoplasms

Genital Neoplasms, Female

Urogenital Neoplasms

Uterine Cervical Diseases

Uterine Diseases

Genital Diseases, Female

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

DNA Virus Infections

Tumor Virus Infections

Women with perinatally acquired HIV aged 18 or over who are sexually active

Women with perinatally acquired HIV aged 18 or over who are not sexually active

HPV test from cervical sample using Cepheid GeneXpert HPV

Human papillomavirus testing

Cervical cytology

HPV type specific serology (16/18) using ELISA from serum samples

HPV serology

Tamara Elliott

Sarah Fidler

This is a cross-sectional, observational study of high-risk HPV status, cervical cytology and HPV vaccine uptake and response in young women with perinatally acquired HIV.

This is an observational study of cervical cytology assessment, high risk human papilloma virus (hr-HPV) status, and HPV antibody titres amongst adult women living with perinatally acquired HIV infection (PaHIV). Eligible consenting participants will have two samples taken; firstly, a cervical sample tested for cytology and Hr-HPV with the Cepheid GeneXpert HPV; secondly serum will be assessed for hr-HPV serology. All women with PaHIV, vaccinated and unvaccinated for HPV, over the age of 18 years will be eligible and will be recruited into one of two cohorts: (1) sexually active women: full study, cervical and blood sampling (n=50) or (2) non-sexually active women, blood sampling only (n=30). Follow up for abnormal smear results or hr-HPV positivity will be arranged through colposcopy.

Screening for HPV and Cervical Cancer in Young Women With Perinatally Acquired HIV

Screening for Human Papillomavirus and Cervical Cancer in Young Women With Perinatally Acquired HIV

Public Health England

Imperial College London

Carcinoma

Carcinoma in Situ

Papilloma

Neoplasms, Squamous Cell

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Women will be offered HPV testing within the health facilities in the communities randomized to this arm. Women who test HPV positive will be referred to care at the sub-district and district hospitals (current standard of care).

Women will be offered HPV-based cervical cancer screening followed by standard linkage to care for women who test positive (to subdistrict or district hospitals).

Women will be offered HPV-based cervical cancer screening followed by enhanced linkage to care using the strategies determined in partnership with the key stakeholders in the communities.

Community-based testing with standard linkage to care

Community-based HPV testing with enhanced linkage to care

Megan J Huchko, MD, MPH

There are many challenges to implementation of cervical cancer prevention in resource-limited countries, despite evidence based screening and treatment strategies. The investigators hypothesize that self-collected HPV specimens offered in a community health campaign setting will

Community-Driven Cervical Cancer Prevention in Western Kenya

Evaluation of a Community-Driven Cervical Cancer Prevention Strategy in Western Kenya

The investigators will determine the cost-effectiveness of the three strategies in this study: clinic-based testing with standard referral to care, community-health campaign testing w/ standard referral to care \& community based testing w/ enhanced linkage to care.

The investigators will compare the number of women who uptake HPV testing in the community health campaign arms compared to the number who uptake HPV testing in the clinic-based arms.

The investigators will compare the number of women accessing treatment for positive HPV results with standard linkage to care compared to the enhanced linkage to treatment strategy.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Screening for HPV and Cervical Cancer in Young Women With Perinatally Acquired HIV	NCT04587050	HIV Infections Human Papilloma... Cervical Cancer	Human papilloma... Cervical cytolo... HPV serology	18 Years -	Imperial College London
Screening for HPV and Cervical Cancer in Young Women With Perinatally Acquired HIV	NCT04587050	HIV Infections Human Papilloma... Cervical Cancer	Human papilloma... Cervical cytolo... HPV serology	18 Years -	Imperial College London
Community-Driven Cervical Cancer Prevention in Western Kenya	NCT02124252	Human Papilloma... Carcinoma in Si...	Community-based... Community-based...	25 Years - 65 Years	Duke University

Spots Global Cancer Trial Database for human papillomavirus testing