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Female Urogenital Diseases and Pregnancy Complications

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Women with perinatally acquired HIV aged 18 or over who are sexually active

Women with perinatally acquired HIV aged 18 or over who are not sexually active

HPV test from cervical sample using Cepheid GeneXpert HPV

Human papillomavirus testing

Cervical cytology

HPV type specific serology (16/18) using ELISA from serum samples

HPV serology

Tamara Elliott

Sarah Fidler

This is a cross-sectional, observational study of high-risk HPV status, cervical cytology and HPV vaccine uptake and response in young women with perinatally acquired HIV.

This is an observational study of cervical cytology assessment, high risk human papilloma virus (hr-HPV) status, and HPV antibody titres amongst adult women living with perinatally acquired HIV infection (PaHIV). Eligible consenting participants will have two samples taken; firstly, a cervical sample tested for cytology and Hr-HPV with the Cepheid GeneXpert HPV; secondly serum will be assessed for hr-HPV serology. All women with PaHIV, vaccinated and unvaccinated for HPV, over the age of 18 years will be eligible and will be recruited into one of two cohorts: (1) sexually active women: full study, cervical and blood sampling (n=50) or (2) non-sexually active women, blood sampling only (n=30). Follow up for abnormal smear results or hr-HPV positivity will be arranged through colposcopy.

Screening for HPV and Cervical Cancer in Young Women With Perinatally Acquired HIV

Screening for Human Papillomavirus and Cervical Cancer in Young Women With Perinatally Acquired HIV

Public Health England

Imperial College London

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Screening for HPV and Cervical Cancer in Young Women With Perinatally Acquired HIV	NCT04587050	HIV Infections Human Papilloma... Cervical Cancer	Human papilloma... Cervical cytolo... HPV serology	18 Years -	Imperial College London
Screening for HPV and Cervical Cancer in Young Women With Perinatally Acquired HIV	NCT04587050	HIV Infections Human Papilloma... Cervical Cancer	Human papilloma... Cervical cytolo... HPV serology	18 Years -	Imperial College London

Spots Global Cancer Trial Database for hpv serology

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