Spots Global Cancer Trial Database for The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy
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Trial Identification
Brief Title: The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy
Official Title: Pilot Studies Testing the Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy
Study ID: NCT05688904
Study Description
Brief Summary: The purpose of this study is testing the use of topical Imipramine in combination with topical photodynamic therapy's (PDT) effect on pain following treatment. PDT is a commonly used treatment in dermatology for patients who have many pre-cancers (actinic keratosis-AKs) on their skin. These are both FDA-approved treatments, but this study is evaluating their use in combination, which has not been evaluated in the past. The investigators have been doing studies using animals that suggest that imipramine might make the PDT less painful and might help it work better. In order to participate, the subject and their dermatologist have decided that they would benefit from PDT to treat their skin due to many AK precancerous lesions. Please note that neither PDT nor imipramine are experimental treatments, but treating their skin with imipramine before PDT is a new approach.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Wright State Physicians, Fairborn, Ohio, United States
Contact Details
Name: Craig Rohan, MD
Affiliation: Wright State University
Role: PRINCIPAL_INVESTIGATOR
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