Symptoms and General Pathology

All Conditions

Neoplasms

Skin and Connective Tissue Diseases

Pain

Keratosis, Actinic

Keratosis

Skin Diseases

Precancerous Conditions

Psychotropic Drugs

All Drugs and Chemicals

Imipramine

Antidepressive Agents

Antidepressive Agents, Tricyclic

Adrenergic Agents

Neurotransmitter Agents

Vehicle

Manager, Clinical Research Operations

Regulatory Specialist

Pharmacology Translational Unit

Craig Rohan, MD

The purpose of this study is testing the use of topical Imipramine in combination with topical photodynamic therapy's (PDT) effect on pain following treatment. PDT is a commonly used treatment in dermatology for patients who have many pre-cancers (actinic keratosis-AKs) on their skin. These are both FDA-approved treatments, but this study is evaluating their use in combination, which has not been evaluated in the past. The investigators have been doing studies using animals that suggest that imipramine might make the PDT less painful and might help it work better. In order to participate, the subject and their dermatologist have decided that they would benefit from PDT to treat their skin due to many AK precancerous lesions. Please note that neither PDT nor imipramine are experimental treatments, but treating their skin with imipramine before PDT is a new approach.

The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy

Pilot Studies Testing the Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy

Principal investigator assesses this from AK lesion count mapping at baseline and in 6 months.

The visual analog pain scale is used to assess this outcome. (0 = no skin pain to 10 = severe skin pain)

The visual analog itch scale will be used to assess this outcome. (0 = no skin itch to 10 = severe skin itch)

Wright State University

Breast Neoplasms

Triple Negative Breast Neoplasms

Breast Diseases

Imipramine will initially be 50mg and this will be increased by 50mg every other day as tolerated to 200 mg.

Imipramine will be given daily for 21-30 days.

Virginia G Kaklamani, MD

Comparing changes in biomarkers from a diagnostic core needle biopsy to surgical pathology specimen or repeat core needle biopsy.

This will be a single arm, non-randomized, pre-surgical clinical trial of women with newly diagnosed triple negative breast cancer comparing changes in biomarkers from a diagnostic core needle biopsy to surgical pathology specimen or repeat core needle biopsy.

Imipramine on ER+ve and Triple Negative Breast Cancer

A Pre-Surgical Window of Opportunity Trial Investigating the Effect of Imipramine on Previously Untreated Breast Cancer (CTMS# 17-0037)

The University of Texas Health Science Center at San Antonio

Principal Investigator

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy	NCT05688904	Imipramine Photodynamic Th... Actinic Keratos...	Imipramine Vehicle	18 Years -	Wright State University
Imipramine on ER+ve and Triple Negative Breast Cancer	NCT03122444	Breast Cancer	Imipramine	18 Years - 71 Years	The University of Texas Health Science Center at San Antonio
The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy	NCT05688904	Imipramine Photodynamic Th... Actinic Keratos...	Imipramine Vehicle	18 Years -	Wright State University
Imipramine on ER+ve and Triple Negative Breast Cancer	NCT03122444	Breast Cancer	Imipramine	18 Years - 71 Years	The University of Texas Health Science Center at San Antonio

Spots Global Cancer Trial Database for imipramine

Every month we try and update this database with for imipramine cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for imipramine

Every month we try and update this database with for imipramine cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for imipramine cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.