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Spots Global Cancer Trial Database for Dose-escalation Trial of Preoperative Radiotherapy and Concurrent Chemotherapy in Locally Advanced Rectal Cancer

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Trial Identification

Brief Title: Dose-escalation Trial of Preoperative Radiotherapy and Concurrent Chemotherapy in Locally Advanced Rectal Cancer

Official Title: Multicenter Dose-escalation Trial of Radiotherapy in Patients With Locally Advanced Rectal Cancer

Study ID: NCT02964468

Study Description

Brief Summary: The aim of this study is to evaluate the increase of radiation dose administered in patients diagnosed with locally advanced rectal cancer in terms of ypRC with tolerable toxicity, using IMRT (concomitant boost technique).

Detailed Description: The hypothesis that arises is an improvement in the proportion of pathological complete responses, resulting therapeutic gain, as a result of a higher dose of radiation delivered to the tumor volume without incurring a higher gastrointestinal toxicity to the patient or surgical complications later, thanks to the use of intensity modulated radiotherapy (concomitant boost technique) that allows us to significantly reduce the administered dose organs at risk.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Hospital General de Elche, Elche, Alicante, Spain

Consorcio Hospitalario Provincial de Castellón, Castellón De La Plana, Castellón, Spain

Hospital Universitario Santiago de Compostela, Santiago de Compostela, La Coruña, Spain

Hospital Universitario Rey Juan Carlos, Mostoles, Madrid, Spain

Hospital General Universitario de Ciudad Real, Ciudad Real, , Spain

Hospital Universitario de Fuenlabrada, Fuenlabrada, , Spain

Hospital Universitario Ramón y Cajal, Madrid, , Spain

Hospital Universitario La Paz, Madrid, , Spain

Hospital Clínico Universitario de Valencia, Valencia, , Spain

Contact Details

Name: Fernando López Campos, Investigator

Affiliation: Hospital Universitario Ramón y Cajal

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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