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Brief Title: Dose-escalation Trial of Preoperative Radiotherapy and Concurrent Chemotherapy in Locally Advanced Rectal Cancer
Official Title: Multicenter Dose-escalation Trial of Radiotherapy in Patients With Locally Advanced Rectal Cancer
Study ID: NCT02964468
Brief Summary: The aim of this study is to evaluate the increase of radiation dose administered in patients diagnosed with locally advanced rectal cancer in terms of ypRC with tolerable toxicity, using IMRT (concomitant boost technique).
Detailed Description: The hypothesis that arises is an improvement in the proportion of pathological complete responses, resulting therapeutic gain, as a result of a higher dose of radiation delivered to the tumor volume without incurring a higher gastrointestinal toxicity to the patient or surgical complications later, thanks to the use of intensity modulated radiotherapy (concomitant boost technique) that allows us to significantly reduce the administered dose organs at risk.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Hospital General de Elche, Elche, Alicante, Spain
Consorcio Hospitalario Provincial de Castellón, Castellón De La Plana, Castellón, Spain
Hospital Universitario Santiago de Compostela, Santiago de Compostela, La Coruña, Spain
Hospital Universitario Rey Juan Carlos, Mostoles, Madrid, Spain
Hospital General Universitario de Ciudad Real, Ciudad Real, , Spain
Hospital Universitario de Fuenlabrada, Fuenlabrada, , Spain
Hospital Universitario Ramón y Cajal, Madrid, , Spain
Hospital Universitario La Paz, Madrid, , Spain
Hospital Clínico Universitario de Valencia, Valencia, , Spain
Name: Fernando López Campos, Investigator
Affiliation: Hospital Universitario Ramón y Cajal
Role: PRINCIPAL_INVESTIGATOR