Spots Global Cancer Trial Database for A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement
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Trial Identification
Brief Title: A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement
Official Title: A TWO-PART, PHASE 1A/B, OPEN-LABEL, MULTICENTER TRIAL EVALUATING PHARMACOKINETICS, SAFETY AND EFFICACY OF PF 07284890 (ARRY 461) IN PARTICIPANTS WITH BRAF V600 MUTANT SOLID TUMORS WITH AND WITHOUT BRAIN INVOLVEMENT
Study ID: NCT04543188
Study Description
Brief Summary: First-in-human study to assess safety, tolerability, PK, and preliminary activity of PF-07284890 as a single agent and in combination with binimetinib in participants with BRAF V600-mutated advanced solid tumor malignancies with and without brain involvement.
Detailed Description:
Eligibility
Minimum Age: 16 Years
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
City of Hope (City of Hope National Medical Center, City of Hope Medical Center), Duarte, California, United States
City of Hope Investigational Drug Services (IDS), Duarte, California, United States
Keck Hospital of USC, Los Angeles, California, United States
LAC + USC Medical Center, Los Angeles, California, United States
Norris Healthcare Center 3 (HC3), Los Angeles, California, United States
USC/Norris Comprehensive Cancer Center, Los Angeles, California, United States
USC/Roski Eye Institute, Los Angeles, California, United States
Keck Medical Center of USC Pasadena, Pasadena, California, United States
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States
UCSF Medical Center, San Francisco, California, United States
Orlando Health Cancer Institute, Orlando, Florida, United States
Moffitt Cancer Center, Tampa, Florida, United States
Richard M Schulze Family Foundation Outpatient Center at McKinley Campus, Tampa, Florida, United States
Northwestern Medical Group, Chicago, Illinois, United States
Northwestern Memorial Hospital, Chicago, Illinois, United States
Community Health Network, Inc., Indianapolis, Indiana, United States
University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States
The University of Kansas Cancer Center - Investigational Drug Services, Fairway, Kansas, United States
The University of Kansas Clinical Research Center, Fairway, Kansas, United States
The University of Kansas Hospital, Kansas City, Kansas, United States
The University of Kansas Cancer Center, Westwood, Kansas, United States
Johns Hopkins University / Johns Hopkins Hospital, Baltimore, Maryland, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Ophthalmic Consultants of Boston Inc (OCB), Boston, Massachusetts, United States
Brigham & Women's Hospital, Boston, Massachusetts, United States
Imaging: Brigham and Women's Hospital, Boston, Massachusetts, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
Imaging: Brigham and Women's Radiology, Coolidge Corner Imaging, Brookline, Massachusetts, United States
Imaging: Brigham and Women's Ambulatory Care, Chestnut Hill, Massachusetts, United States
Imaging: Brigham and Women's Mass General Healthcare Center, Foxboro, Massachusetts, United States
Dana-Farber Cancer Institute - Chestnut Hill, Newton, Massachusetts, United States
Michigan Health Professionals (PI Clinic), Farmington Hills, Michigan, United States
Revive Research Institute, Sterling Heights, Michigan, United States
HealthPartners Cancer Center at Regions Hospital, Saint Paul, Minnesota, United States
Regions Hospital Pharmacy, Saint Paul, Minnesota, United States
Siteman Cancer Center - West County, Creve Coeur, Missouri, United States
Siteman Cancer Center - North County, Florissant, Missouri, United States
Barnes-Jewish Hospital, Saint Louis, Missouri, United States
Washington University Infusion Center Pharmacy, Saint Louis, Missouri, United States
Washington University School of Medicine, Saint Louis, Missouri, United States
Siteman Cancer Center - South County, Saint Louis, Missouri, United States
Siteman Cancer Center - St Peters, Saint Peters, Missouri, United States
Hackensack University Medical Center, Hackensack, New Jersey, United States
John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey, United States
MSK Monmouth., Middletown, New Jersey, United States
MSK Commack, Commack, New York, United States
MSKCC-Westchester (500 Westchester Ave.), Harrison, New York, United States
Laura and Isaac Perlmutter Cancer Center, New York, New York, United States
NYU Langone Health, New York, New York, United States
NYU Langone Medical Center (Tisch Hospital), New York, New York, United States
NYU Langone Radiology- ACC East 41st street, New York, New York, United States
Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street)., New York, New York, United States
Memorial Sloan Kettering Cancer Center Rockefeller Outpatient Pavilion, New York, New York, United States
Rockefeller Outpatient Pavilion (53rd Street), New York, New York, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
UNC Cancer Hospital Infusion Pharmacy, Chapel Hill, North Carolina, United States
UNC Hospitals, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
Duke Eye Center, Durham, North Carolina, United States
Duke University Medical Center, Investigational Chemotherapy Services, Durham, North Carolina, United States
Duke University Medical Center, Durham, North Carolina, United States
Carl & Edyth Lindner Center for Research & Education at TCH and TCH Cancer Center, Cincinnati, Ohio, United States
University of Cincinnati Medical Center, Cincinnati, Ohio, United States
West Chester Hospital, West Chester, Ohio, United States
Tennessee Oncology PLLC, Franklin, Tennessee, United States
Sarah Cannon Research Institute - Pharmacy, Nashville, Tennessee, United States
Tennessee Oncology PLLC, Nashville, Tennessee, United States
The University of Texas MD Anderson Cancer Center, Houston, Texas, United States
The University of Texas MD Anderson Cancer Center, Houston, Texas, United States
University of Wisconsin Hospitals and Clinics, Madison, Wisconsin, United States
Hamilton Health Sciences-Juravinski Cancer Centre, Hamilton, Ontario, Canada
Sunnybrook Research Institute, Toronto, Ontario, Canada
Princess Margaret Cancer Centre, Toronto, Ontario, Canada
Jewish General Hospital, Montreal, Quebec, Canada
Rambam Health Care Campus, Haifa, ?eif?, Israel
Rabin Medical Center, Petah-Tikva, Hamerkaz, Israel
Sheba Medical Center, Ramat Gan, Hamerkaz, Israel
Sourasky Medical Center, Tel Aviv, Tell Abīb, Israel
Hadassah Medical Center, Jerusalem, Yerushalayim, Israel
Contact Details
Name: Pfizer CT.gov Call Center
Affiliation: Pfizer
Role: STUDY_DIRECTOR
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