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Spots Global Cancer Trial Database for Zoledronate in Preventing Skeletal (Bone)-Related Events in Men Who Are Receiving Androgen Deprivation Therapy For Prostate Cancer and Bone Metastases

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Trial Identification

Brief Title: Zoledronate in Preventing Skeletal (Bone)-Related Events in Men Who Are Receiving Androgen Deprivation Therapy For Prostate Cancer and Bone Metastases

Official Title: A Randomized Double-Blind, Placebo-Controlled Phase III Study of Early Versus Standard Zoledronic Acid to Prevent Skeletal Related Events in Men With Prostate Cancer Metastatic to Bone

Study ID: NCT00079001

Study Description

Brief Summary: RATIONALE: Zoledronate may prevent or decrease skeletal (bone)-related events (such as pain or fractures) caused by bone metastases and androgen deprivation therapy. It is not yet known whether treatment with zoledronate is effective in preventing bone-related events in patients who have prostate cancer and bone metastases. PURPOSE: This randomized phase III trial is studying how well zoledronate works in preventing bone-related events in patients who are receiving androgen deprivation therapy for prostate cancer and bone metastases.

Detailed Description: Zoledronic acid decreases the risk of skeletal related events in men with prostate cancer metastatic to bone and disease progression after primary hormonal therapy. This study is designed to evaluate whether earlier treatment with zoledronic acid will further decrease the risk of skeletal related events. This is a randomized, double-blind, placebo-controlled, multicenter study followed by an open-label study. Patients are stratified according to ECOG performance status (0-1 vs 2), prior skeletal-related event (no vs yes), and serum alkaline phosphatase (\< upper limit of normal \[ULN\] vs ≥ ULN). The primary objective of the study is to determine whether treatment with zoledronic acid at the time of initiation of androgen deprivation therapy for metastatic prostate cancer will delay the time to first skeletal related event. The secondary objective of the study is to compare the effect of treatment with zoledronic acid to placebo on overall survival (OS), progression-free survival (PFS) and toxicity in men receiving androgen deprivation therapy for metastatic prostate cancer. Patients are randomized to 1 of 2 treatment arms. Treatment continues in the absence of disease progression or a skeletal-related event. All patients receive concurrent androgen deprivation therapy with a GnRH agonist. Patients also receive oral calcium and (vitamin D) supplements daily. Patients progressing to androgen-independent prostate cancer proceed to the open-label therapy with zoledronic acid IV. Treatment continues for 3 weeks in the absence of disease progression or the first skeletal-related event. Patients are followed periodically for approximately 10 years after entry on the study.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: MALE

Healthy Volunteers: No

Locations

Providence Cancer Center at Providence Hospital, Mobile, Alabama, United States

Hembree Mercy Cancer Center at St. Edward Mercy Medical Center, Fort Smith, Arkansas, United States

Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States

Veterans Affairs Medical Center - Loma Linda (Pettis), Loma Linda, California, United States

, Pismo Beach, California, United States

Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center, Pomona, California, United States

Saint Helena Hospital, Saint Helena, California, United States

Salinas Valley Memorial Hospital, Salinas, California, United States

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States

Ruby L. Golleher Cancer Program at Presbyterian Intercommunity Hospital, Whittier, California, United States

Yale Cancer Center, New Haven, Connecticut, United States

Veterans Affairs Medical Center - West Haven, West Haven, Connecticut, United States

Kaiser Permanente at Capitol Hill Medical Center, Washington, District of Columbia, United States

Lombardi Comprehensive Cancer Center at Georgetown University Medical Center, Washington, District of Columbia, United States

Leesburg Regional Medical Center, Leesburg, Florida, United States

Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler, Savannah, Georgia, United States

Kapiolani Medical Center at Pali Momi, 'Aiea, Hawaii, United States

Cancer Research Center of Hawaii, Honolulu, Hawaii, United States

OnCare Hawaii, Incorporated - Lusitana, Honolulu, Hawaii, United States

Queen's Cancer Institute at Queen's Medical Center, Honolulu, Hawaii, United States

Straub Clinic and Hospital, Incorporated, Honolulu, Hawaii, United States

Hawaii Medical Center - East, Honolulu, Hawaii, United States

OnCare Hawaii, Incorporated - Kuakini, Honolulu, Hawaii, United States

Kapiolani Medical Center for Women and Children, Honolulu, Hawaii, United States

Pacific Cancer Institute - Maui, Wailuku, Hawaii, United States

Rush-Copley Cancer Care Center, Aurora, Illinois, United States

University of Illinois Cancer Center, Chicago, Illinois, United States

Veterans Affairs Medical Center - Chicago Westside Hospital, Chicago, Illinois, United States

University of Chicago Cancer Research Center, Chicago, Illinois, United States

Louis A. Weiss Memorial Hospital, Chicago, Illinois, United States

Elmhurst Memorial Hospital, Elmhurst, Illinois, United States

Veterans Affairs Medical Center - Hines, Hines, Illinois, United States

Provena St. Mary's Regional Cancer Center - Kankakee, Kankakee, Illinois, United States

La Grange Memorial Hospital, La Grange, Illinois, United States

Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood, Illinois, United States

Carle Cancer Center at Carle Foundation Hospital, Urbana, Illinois, United States

CCOP - Carle Cancer Center, Urbana, Illinois, United States

Elkhart Clinic, LLC, Elkhart, Indiana, United States

Michiana Hematology-Oncology, PC - Elkhart, Elkhart, Indiana, United States

Elkhart General Hospital, Elkhart, Indiana, United States

Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, United States

William N. Wishard Memorial Hospital, Indianapolis, Indiana, United States

Howard Community Hospital, Kokomo, Indiana, United States

Center for Cancer Therapy at LaPorte Hospital and Health Services, La Porte, Indiana, United States

Saint Anthony Memorial Health Centers, Michigan City, Indiana, United States

Michiana Hematology-Oncology, PC - South Bend, Mishawaka, Indiana, United States

Saint Joseph Regional Medical Center, Mishawaka, Indiana, United States

Michiana Hematology Oncology PC - Plymouth, Plymouth, Indiana, United States

CCOP - Northern Indiana CR Consortium, South Bend, Indiana, United States

Memorial Hospital of South Bend, South Bend, Indiana, United States

Michiana Hematology Oncology PC - La Porte, Westville, Indiana, United States

Heartland Oncology and Hematology, Council Bluffs, Iowa, United States

Holden Comprehensive Cancer Center at University of Iowa, Iowa City, Iowa, United States

Veterans Affairs Medical Center - Iowa City, Iowa City, Iowa, United States

Covenant Cancer Treatment Center, Waterloo, Iowa, United States

Cotton-O'Neil Cancer Center, Topeka, Kansas, United States

Mary Bird Perkins Cancer Center - Baton Rouge, Baton Rouge, Louisiana, United States

Louisiana State University Health Sciences Center - Monroe, Monroe, Louisiana, United States

MBCCOP - LSU Health Sciences Center, New Orleans, Louisiana, United States

Medical Center of Louisiana - New Orleans, New Orleans, Louisiana, United States

Highland Clinic, Shreveport, Louisiana, United States

Feist-Weiller Cancer Center at Louisiana State University Health Sciences, Shreveport, Louisiana, United States

Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore, Maryland, United States

Veterans Affairs Medical Center - Baltimore, Baltimore, Maryland, United States

Union Memorial Hospital, Baltimore, Maryland, United States

Good Samaritan Hospital of Maryland, Baltimore, Maryland, United States

Kaiser Permanente at Woodlawn Medical Center, Baltimore, Maryland, United States

Shore Regional Cancer Center at Memorial Hospital - Easton, Easton, Maryland, United States

John R. Marsh Cancer Center at Washington County Hospital, Hagerstown, Maryland, United States

Kaiser Permanente Mid-Atlantic Medical Group-Largo Medical Facility, Largo, Maryland, United States

Kaiser Permanente Capital Area Medical Group - Shady Grove Facility, Rockville, Maryland, United States

Massachusetts General Hospital, Boston, Massachusetts, United States

Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts, United States

Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Lowell General Hospital, Lowell, Massachusetts, United States

Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Medical Center, Milford, Massachusetts, United States

Hickman Cancer Center at Bixby Medical Center, Adrian, Michigan, United States

Josephine Ford Cancer Center at Henry Ford Hospital, Detroit, Michigan, United States

Green Bay Oncology, Limited - Escanaba, Escanaba, Michigan, United States

Dickinson County Healthcare System, Iron Mountain, Michigan, United States

Borgess Medical Center, Kalamazoo, Michigan, United States

West Michigan Cancer Center, Kalamazoo, Michigan, United States

Bronson Methodist Hospital, Kalamazoo, Michigan, United States

Community Cancer Center of Monroe, Monroe, Michigan, United States

Mercy Memorial Hospital - Monroe, Monroe, Michigan, United States

Michiana Hematology Oncology PC - Niles, Niles, Michigan, United States

Lakeland Regional Cancer Care Center - St. Joseph, Saint Joseph, Michigan, United States

Lakeside Cancer Specialists, PLLC, Saint Joseph, Michigan, United States

Fairview Ridges Hospital, Burnsville, Minnesota, United States

Mercy and Unity Cancer Center at Mercy Hospital, Coon Rapids, Minnesota, United States

Duluth Clinic Cancer Center - Duluth, Duluth, Minnesota, United States

CCOP - Duluth, Duluth, Minnesota, United States

Miller - Dwan Medical Center, Duluth, Minnesota, United States

Fairview Southdale Hospital, Edina, Minnesota, United States

Mercy and Unity Cancer Center at Unity Hospital, Fridley, Minnesota, United States

Hutchinson Area Health Care, Hutchinson, Minnesota, United States

HealthEast Cancer Care at St. John's Hospital, Maplewood, Minnesota, United States

Minnesota Oncology Hematology, PA - Maplewood, Maplewood, Minnesota, United States

Virginia Piper Cancer Institute at Abbott - Northwestern Hospital, Minneapolis, Minnesota, United States

Hennepin County Medical Center - Minneapolis, Minneapolis, Minnesota, United States

Humphrey Cancer Center at North Memorial Outpatient Center, Robbinsdale, Minnesota, United States

CCOP - Metro-Minnesota, Saint Louis Park, Minnesota, United States

Park Nicollet Cancer Center, Saint Louis Park, Minnesota, United States

Regions Hospital Cancer Care Center, Saint Paul, Minnesota, United States

United Hospital, Saint Paul, Minnesota, United States

Lakeview Hospital, Stillwater, Minnesota, United States

Ridgeview Medical Center, Waconia, Minnesota, United States

Willmar Cancer Center at Rice Memorial Hospital, Willmar, Minnesota, United States

Minnesota Oncology Hematology, PA - Woodbury, Woodbury, Minnesota, United States

Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis, Saint Louis, Missouri, United States

CCOP - Montana Cancer Consortium, Billings, Montana, United States

St. Vincent Healthcare Cancer Care Services, Billings, Montana, United States

Hematology-Oncology Centers of the Northern Rockies - Billings, Billings, Montana, United States

Billings Clinic - Downtown, Billings, Montana, United States

Bozeman Deaconess Cancer Center, Bozeman, Montana, United States

St. James Healthcare Cancer Care, Butte, Montana, United States

Big Sky Oncology, Great Falls, Montana, United States

Great Falls Clinic - Main Facility, Great Falls, Montana, United States

Sletten Cancer Institute at Benefis Healthcare, Great Falls, Montana, United States

St. Peter's Hospital, Helena, Montana, United States

Glacier Oncology, PLLC, Kalispell, Montana, United States

Kalispell Medical Oncology at KRMC, Kalispell, Montana, United States

Kalispell Regional Medical Center, Kalispell, Montana, United States

Montana Cancer Specialists at Montana Cancer Center, Missoula, Montana, United States

Montana Cancer Center at St. Patrick Hospital and Health Sciences Center, Missoula, Montana, United States

Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center, Grand Island, Nebraska, United States

Good Samaritan Cancer Center at Good Samaritan Hospital, Kearney, Nebraska, United States

Cancer Resource Center - Lincoln, Lincoln, Nebraska, United States

Callahan Cancer Center at Great Plains Regional Medical Center, North Platte, Nebraska, United States

CCOP - Missouri Valley Cancer Consortium, Omaha, Nebraska, United States

Methodist Estabrook Cancer Center, Omaha, Nebraska, United States

Immanuel Medical Center, Omaha, Nebraska, United States

Alegant Health Cancer Center at Bergan Mercy Medical Center, Omaha, Nebraska, United States

Lakeside Hospital, Omaha, Nebraska, United States

Creighton University Medical Center, Omaha, Nebraska, United States

UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha, Nebraska, United States

University Medical Center of Southern Nevada, Las Vegas, Nevada, United States

CCOP - Nevada Cancer Research Foundation, Las Vegas, Nevada, United States

Nevada Cancer Institute, Las Vegas, Nevada, United States

New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care, Concord, New Hampshire, United States

Center for Cancer Care at Exeter Hospital, Exeter, New Hampshire, United States

New Hampshire Oncology - Hematology, PA - Hooksett, Hooksett, New Hampshire, United States

Dana-Farber Cancer Institute at Londonderry, Londonderry, New Hampshire, United States

Elliot Regional Cancer Center at Elliot Hospital, Manchester, New Hampshire, United States

Veterans Affairs Medical Center - East Orange, East Orange, New Jersey, United States

Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare, Vineland, New Jersey, United States

Lovelace Medical Center - Downtown, Albuquerque, New Mexico, United States

University of New Mexico Cancer Center, Albuquerque, New Mexico, United States

Kings County Hospital Center, Brooklyn, New York, United States

SUNY Downstate Medical Center, Brooklyn, New York, United States

Veterans Affairs Medical Center - Buffalo, Buffalo, New York, United States

Roswell Park Cancer Institute, Buffalo, New York, United States

CCOP - Hematology-Oncology Associates of Central New York, East Syracuse, New York, United States

New York Weill Cornell Cancer Center at Cornell University, New York, New York, United States

SUNY Upstate Medical University Hospital, Syracuse, New York, United States

Veterans Affairs Medical Center - Syracuse, Syracuse, New York, United States

Duke Cancer Institute, Durham, North Carolina, United States

Kinston Medical Specialists, Kinston, North Carolina, United States

Southeastern Regional Medical Center, Lumberton, North Carolina, United States

Granville Medical Center, Oxford, North Carolina, United States

Duke Health Raleigh Hospital, Raleigh, North Carolina, United States

Person Memorial Hospital, Roxboro, North Carolina, United States

Wood County Oncology Center, Bowling Green, Ohio, United States

MetroHealth Cancer Care Center at MetroHealth Medical Center, Cleveland, Ohio, United States

Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

St. Rita's Medical Center, Lima, Ohio, United States

Lima Memorial Hospital, Lima, Ohio, United States

Northwest Ohio Oncology Center, Maumee, Ohio, United States

Fisher-Titus Medical Center, Norwalk, Ohio, United States

St. Charles Mercy Hospital, Oregon, Ohio, United States

Toledo Clinic - Oregon, Oregon, Ohio, United States

North Coast Cancer Care, Incorporated, Sandusky, Ohio, United States

Flower Hospital Cancer Center, Sylvania, Ohio, United States

Mercy Hospital of Tiffin, Tiffin, Ohio, United States

Toledo Hospital, Toledo, Ohio, United States

St. Vincent Mercy Medical Center, Toledo, Ohio, United States

Medical University of Ohio Cancer Center, Toledo, Ohio, United States

CCOP - Toledo Community Hospital, Toledo, Ohio, United States

St. Anne Mercy Hospital, Toledo, Ohio, United States

Toledo Clinic, Incorporated - Main Clinic, Toledo, Ohio, United States

Fulton County Health Center, Wauseon, Ohio, United States

Oklahoma University Cancer Institute, Oklahoma City, Oklahoma, United States

Bay Area Hospital, Coos Bay, Oregon, United States

Kaiser Permanente Health Care - Portland, Portland, Oregon, United States

Mercy Hospital Cancer Center - Scranton, Scranton, Pennsylvania, United States

Susquehanna Cancer Center at Divine Providence Hospital, Williamsport, Pennsylvania, United States

Greenville Hospital Cancer Center, Greenville, South Carolina, United States

CCOP - Greenville, Greenville, South Carolina, United States

Self Regional Cancer Center at Self Regional Medical Center, Greenwood, South Carolina, United States

MBCCOP - Meharry Medical College - Nashville, Nashville, Tennessee, United States

Baylor University Medical Center - Houston, Houston, Texas, United States

Ben Taub General Hospital, Houston, Texas, United States

St. Luke's Texas Cancer Institute at St. Luke's Episcopal Hospital, Houston, Texas, United States

Veterans Affairs Medical Center - Houston, Houston, Texas, United States

American Fork Hospital, American Fork, Utah, United States

Sandra L. Maxwell Cancer Center, Cedar City, Utah, United States

Logan Regional Hospital, Logan, Utah, United States

Jon and Karen Huntsman Cancer Center at Intermountain Medical Center, Murray, Utah, United States

Val and Ann Browning Cancer Center at McKay-Dee Hospital Center, Ogden, Utah, United States

Utah Valley Regional Medical Center - Provo, Provo, Utah, United States

Dixie Regional Medical Center - East Campus, Saint George, Utah, United States

Utah Cancer Specialists at UCS Cancer Center, Salt Lake City, Utah, United States

Huntsman Cancer Institute at University of Utah, Salt Lake City, Utah, United States

LDS Hospital, Salt Lake City, Utah, United States

Mountainview Medical, Berlin, Vermont, United States

Fletcher Allen Health Care - University Health Center Campus, Burlington, Vermont, United States

Kaiser Permanente Medical Center - Fair Oaks, Fairfax, Virginia, United States

Fredericksburg Oncology, Incorporated, Fredericksburg, Virginia, United States

Lynchburg Hematology-Oncology Clinic, Lynchburg, Virginia, United States

Island Hospital Cancer Care Center at Island Hospital, Anacortes, Washington, United States

St. Joseph Cancer Center, Bellingham, Washington, United States

Olympic Hematology and Oncology, Bremerton, Washington, United States

Highline Medical Center Cancer Center, Burien, Washington, United States

Columbia Basin Hematology, Kennewick, Washington, United States

Skagit Valley Hospital Cancer Care Center, Mount Vernon, Washington, United States

Minor and James Medical, PLLC, Seattle, Washington, United States

Group Health Central Hospital, Seattle, Washington, United States

Swedish Cancer Institute at Swedish Medical Center - First Hill Campus, Seattle, Washington, United States

University Cancer Center at University of Washington Medical Center, Seattle, Washington, United States

North Puget Oncology at United General Hospital, Sedro-Woolley, Washington, United States

Cancer Care Northwest - Spokane South, Spokane, Washington, United States

Rockwood Clinic Cancer Treatment Center, Spokane, Washington, United States

Evergreen Hematology and Oncology, PS, Spokane, Washington, United States

Wenatchee Valley Medical Center, Wenatchee, Washington, United States

Langlade Memorial Hospital, Antigo, Wisconsin, United States

Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center, Green Bay, Wisconsin, United States

Green Bay Oncology, Limited at St. Mary's Hospital, Green Bay, Wisconsin, United States

St. Mary's Hospital Medical Center - Green Bay, Green Bay, Wisconsin, United States

St. Vincent Hospital Regional Cancer Center, Green Bay, Wisconsin, United States

Holy Family Memorial Medical Center Cancer Care Center, Manitowoc, Wisconsin, United States

Bay Area Cancer Care Center at Bay Area Medical Center, Marinette, Wisconsin, United States

Wheaton Franciscan Cancer Care - St. Joseph, Milwaukee, Wisconsin, United States

Green Bay Oncology, Limited - Oconto Falls, Oconto Falls, Wisconsin, United States

St. Nicholas Hospital, Sheboygan, Wisconsin, United States

Green Bay Oncology, Limited - Sturgeon Bay, Sturgeon Bay, Wisconsin, United States

University of Wisconcin Cancer Center at Aspirus Wausau Hospital, Wausau, Wisconsin, United States

Riverview UW Cancer Center at Riverview Hospital, Wisconsin Rapids, Wisconsin, United States

Welch Cancer Center at Sheridan Memorial Hospital, Sheridan, Wyoming, United States

Cross Cancer Institute at University of Alberta, Edmonton, Alberta, Canada

University of British Columbia, Vancouver, British Columbia, Canada

London Regional Cancer Program at London Health Sciences Centre, London, Ontario, Canada

Contact Details

Name: Matthew R. Smith, MD, PhD

Affiliation: Massachusetts General Hospital

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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