Spots Global Cancer Trial Database for S0421, Docetaxel and Prednisone With or Without Atrasentan in Treating Patients With Stage IV Prostate Cancer and Bone Metastases That Did Not Respond to Previous Hormone Therapy
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Trial Identification
Brief Title: S0421, Docetaxel and Prednisone With or Without Atrasentan in Treating Patients With Stage IV Prostate Cancer and Bone Metastases That Did Not Respond to Previous Hormone Therapy
Official Title: Phase III Study of Docetaxel and Atrasentan Versus Docetaxel and Placebo for Patients With Advanced Hormone Refractory Prostate Cancer
Study ID: NCT00134056
Study Description
Brief Summary: RATIONALE: Drugs used in chemotherapy, such as docetaxel, prednisone, and atrasentan work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. It is not yet known whether docetaxel, prednisone, and atrasentan are more effective than docetaxel and prednisone in treating prostate cancer. PURPOSE: This randomized phase III trial is studying docetaxel, prednisone, and atrasentan to see how well they work compared to docetaxel and prednisone in treating patients with stage IV prostate cancer and bone metastases that did not respond to previous hormone therapy.
Detailed Description: OBJECTIVES: Primary * Compare the survival and progression-free survival of patients with hormone-refractory stage IV prostate cancer and bone metastases treated with docetaxel and prednisone combined with either atrasentan vs placebo. Secondary * Compare pain progression of patients treated with these regimens. * Compare the qualitative and quantitative toxicity of these regimens in these patients. * Compare the quality of life, in terms of palliation of metastatic bone pain and improvement in functional status, of patients treated with these regimens. * Compare prostate-specific antigen (PSA) response rates in patients treated with these regimens. * Compare objective response in patients with measurable disease treated with these regimens. * Determine whether a 30% reduction in PSA and the slope of PSA from baseline to 3 months is a surrogate marker for survival in patients treated with these regimens. * Correlate PSA progression with clinical progression and death in patients treated with these regimens. OUTLINE: This is a randomized, double-blind, placebo-controlled, multicenter study. Patients are stratified according to disease progression (measurable or non-measurable disease progression vs prostate-specific antigen progression only), use of bisphosphonates at study entry (yes vs no), worst pain, measured by the Brief Pain Inventory "pain" scale (\< grade 4 vs ≥ grade 4), and extraskeletal metastases (yes vs no). Patients are randomized to 1 of 2 treatment arms. * Arm I: Patients receive docetaxel IV over 1 hour on day 1. Patients also receive oral atrasentan and oral prednisone once daily on days 1-21. Treatment repeats every 21 days for up to 12 courses. Patients with stable or responding disease after course 12 may register for continued oral atrasentan treatment for up to 52 weeks in the absence of disease progression\* or unacceptable toxicity. * Arm II: Patients receive docetaxel and prednisone as in arm I. Patients also receive oral placebo once daily on days 1-21. Treatment repeat every 21 days for up to 12 courses. Patients with stable or responding disease after course 12 may register for continued oral placebo treatment for up to 52 weeks in the absence of disease progression\* or unacceptable toxicity. NOTE: \*Patients with PSA progression alone will be allowed to continue treatment Quality of life is assessed at baseline, before courses 4, 7, and 10, and then after completion of study treatment. After completion of study treatment, patients are followed every 3 months for 1 year and then every 6 months for up to 3 years from study entry. PROJECTED ACCRUAL: A total of 930 patients will be accrued for this study within 4 years.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: MALE
Healthy Volunteers: No
Locations
Providence Cancer Center at Providence Hospital, Mobile, Alabama, United States
Alaska Regional Hospital Cancer Center, Anchorage, Alaska, United States
Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital, Fairbanks, Alaska, United States
Mayo Clinic Scottsdale, Scottsdale, Arizona, United States
Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson, Arizona, United States
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center, Fort Smith, Arkansas, United States
East Bay Radiation Oncology Center, Castro Valley, California, United States
Eden Medical Center, Castro Valley, California, United States
Valley Medical Oncology Consultants - Castro Valley, Castro Valley, California, United States
Valley Medical Oncology, Fremont, California, United States
Cancer Care Associates, Fresno, California, United States
Glendale Memorial Hospital Comprehensive Cancer Center, Glendale, California, United States
Rebecca and John Moores UCSD Cancer Center, La Jolla, California, United States
USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles, California, United States
Contra Costa Regional Medical Center, Martinez, California, United States
Tibotec Therapeutics - Division of Ortho Biotech Products, LP, Marysville, California, United States
Community Hospital of the Monterey Peninsula Comprehensive Cancer Center, Monterey, California, United States
Camino Medical Group - Treatment Center, Mountain View, California, United States
El Camino Hospital Cancer Center, Mountain View, California, United States
Highland General Hospital, Oakland, California, United States
Alta Bates Summit Medical Center - Summit Campus, Oakland, California, United States
Bay Area Breast Surgeons, Incorporated, Oakland, California, United States
CCOP - Bay Area Tumor Institute, Oakland, California, United States
Larry G Strieff MD Medical Corporation, Oakland, California, United States
Tom K Lee, Incorporated, Oakland, California, United States
Desert Regional Medical Center Comprehensive Cancer Center, Palm Springs, California, United States
Palo Alto Medical Foundation, Palo Alto, California, United States
PCR Oncology, Pismo Beach, California, United States
Valley Care Medical Center, Pleasanton, California, United States
Valley Medical Oncology Consultants - Pleasanton, Pleasanton, California, United States
Lucy Curci Cancer Center at Eisenhower Memorial Hospital and Medical Center, Rancho Mirage, California, United States
University of California Davis Cancer Center, Sacramento, California, United States
Mercy General Hospital, Sacramento, California, United States
Salinas Valley Memorial Hospital, Salinas, California, United States
Doctors Medical Center - San Pablo Campus, San Pablo, California, United States
Tahoe Forest Cancer Center, Truckee, California, United States
Aurora Presbyterian Hospital, Aurora, Colorado, United States
University of Colorado Cancer Center at UC Health Sciences Center, Aurora, Colorado, United States
Boulder Community Hospital, Boulder, Colorado, United States
Penrose Cancer Center at Penrose Hospital, Colorado Springs, Colorado, United States
Denver Health Medical Center, Denver, Colorado, United States
St. Anthony Central Hospital, Denver, Colorado, United States
Porter Adventist Hospital, Denver, Colorado, United States
Presbyterian - St. Luke's Medical Center, Denver, Colorado, United States
St. Joseph Hospital, Denver, Colorado, United States
Rose Medical Center, Denver, Colorado, United States
Veterans Affairs Medical Center - Denver, Denver, Colorado, United States
CCOP - Colorado Cancer Research Program, Denver, Colorado, United States
Shaw Regional Cancer Center, Edwards, Colorado, United States
Swedish Medical Center, Englewood, Colorado, United States
Poudre Valley Hospital, Fort Collins, Colorado, United States
Front Range Cancer Specialists, Fort Collins, Colorado, United States
Valley View Hospital Cancer Center, Glenwood Springs, Colorado, United States
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center, Grand Junction, Colorado, United States
North Colorado Medical Center, Greeley, Colorado, United States
Sky Ridge Medical Center, Lone Tree, Colorado, United States
Hope Cancer Care Center at Longmont United Hospital, Longmont, Colorado, United States
McKee Medical Center, Loveland, Colorado, United States
Montrose Memorial Hospital Cancer Center, Montrose, Colorado, United States
St. Mary - Corwin Regional Medical Center, Pueblo, Colorado, United States
North Suburban Medical Center, Thornton, Colorado, United States
Exempla Lutheran Medical Center, Wheat Ridge, Colorado, United States
Praxair Cancer Center at Danbury Hospital, Danbury, Connecticut, United States
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center, Hartford, Connecticut, United States
Manchester Memorial Hospital, Manchester, Connecticut, United States
Middlesex Hospital Cancer Center, Middletown, Connecticut, United States
Connecticut Oncology & Hematology - Torrington, Torrington, Connecticut, United States
CCOP - Christiana Care Health Services, Newark, Delaware, United States
Lombardi Comprehensive Cancer Center at Georgetown University Medical Center, Washington, District of Columbia, United States
Sibley Memorial Hospital, Washington, District of Columbia, United States
Veterans Affairs Medical Center - Washington, DC, Washington, District of Columbia, United States
Broward General Medical Center Cancer Center, Fort Lauderdale, Florida, United States
Memorial Cancer Institute at Memorial Regional Hospital, Hollywood, Florida, United States
Cancer Centers of Central Florida, PA, Leesburg, Florida, United States
University of Miami Sylvester Comprehensive Cancer Center - Miami, Miami, Florida, United States
Integrated Community Oncology Network - Orange Park, Orange Park, Florida, United States
Florida Hospital Cancer Institute at Florida Hospital Orlando, Orlando, Florida, United States
Sacred Heart Cancer Center at Sacred Heart Hospital, Pensacola, Florida, United States
West Florida Cancer Institute at West Florida Hospital - Pensacola, Pensacola, Florida, United States
Space Coast Medical Associates, Titusville, Florida, United States
Northeast Georgia Cancer Care, LLC - Medical Oncology, Athens, Georgia, United States
Piedmont Hospital, Atlanta, Georgia, United States
Northside Hospital Cancer Center, Atlanta, Georgia, United States
Saint Joseph's Hospital of Atlanta, Atlanta, Georgia, United States
CCOP - Atlanta Regional, Atlanta, Georgia, United States
MBCCOP - Medical College of Georgia Cancer Center, Augusta, Georgia, United States
WellStar Cobb Hospital, Austell, Georgia, United States
Charles B. Eberhart Cancer Center at DeKalb Medical Center, Decatur, Georgia, United States
Gwinnett Medical Center, Lawrenceville, Georgia, United States
Kennestone Cancer Center at Wellstar Kennestone Hospital, Marietta, Georgia, United States
Southern Regional Medical Center, Riverdale, Georgia, United States
Harbin Clinic Cancer Center - Medical Oncology, Rome, Georgia, United States
Kapiolani Medical Center at Pali Momi, 'Aiea, Hawaii, United States
Cancer Research Center of Hawaii, Honolulu, Hawaii, United States
OnCare Hawaii, Incorporated - Lusitana, Honolulu, Hawaii, United States
Queen's Cancer Institute at Queen's Medical Center, Honolulu, Hawaii, United States
Straub Clinic and Hospital, Incorporated, Honolulu, Hawaii, United States
Hawaii Medical Center - East, Honolulu, Hawaii, United States
OnCare Hawaii, Incorporated - Kuakini, Honolulu, Hawaii, United States
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii, United States
Tripler Army Medical Center, Honolulu, Hawaii, United States
Maui Memorial Medical Center, Wailuku, Hawaii, United States
Pacific Cancer Institute - Maui, Wailuku, Hawaii, United States
Mountain States Tumor Institute at St. Luke's Regional Medical Center, Boise, Idaho, United States
Saint Anthony's Hospital at Saint Anthony's Health Center, Alton, Illinois, United States
Rush-Copley Cancer Care Center, Aurora, Illinois, United States
Mount Sinai Hospital Medical Center, Chicago, Illinois, United States
University of Illinois Cancer Center, Chicago, Illinois, United States
Resurrection Medical Center, Chicago, Illinois, United States
Creticos Cancer Center at Advocate Illinois Masonic Medical Center, Chicago, Illinois, United States
Decatur Memorial Hospital Cancer Care Institute, Decatur, Illinois, United States
Sherman Hospital, Elgin, Illinois, United States
Alexian Brothers Radiation Oncology, Elk Grove Village, Illinois, United States
Elmhurst Memorial Hospital, Elmhurst, Illinois, United States
Evanston Hospital, Evanston, Illinois, United States
Leonard C. Ferguson Cancer Center, Freeport, Illinois, United States
Ingalls Cancer Care Center at Ingalls Memorial Hospital, Harvey, Illinois, United States
Veterans Affairs Medical Center - Hines, Hines, Illinois, United States
Joliet Oncology-Hematology Associates, Limited - West, Joliet, Illinois, United States
Provena St. Mary's Regional Cancer Center - Kankakee, Kankakee, Illinois, United States
La Grange Memorial Hospital, La Grange, Illinois, United States
Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood, Illinois, United States
Good Samaritan Regional Health Center, Mount Vernon, Illinois, United States
Edward Hospital Cancer Center, Naperville, Illinois, United States
Hematology Oncology Consultants - Naperville, Naperville, Illinois, United States
Swedish-American Regional Cancer Center, Rockford, Illinois, United States
Regional Cancer Center at Memorial Medical Center, Springfield, Illinois, United States
Carle Cancer Center at Carle Foundation Hospital, Urbana, Illinois, United States
CCOP - Carle Cancer Center, Urbana, Illinois, United States
Central Dupage Cancer Center, Winfield, Illinois, United States
St. Francis Hospital and Health Centers - Beech Grove Campus, Beech Grove, Indiana, United States
Bloomington Hospital Regional Cancer Institute, Bloomington, Indiana, United States
Elkhart General Hospital, Elkhart, Indiana, United States
Center for Cancer Care at Goshen General Hospital, Goshen, Indiana, United States
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, United States
Veterans Affairs Medical Center - Indianapolis, Indianapolis, Indiana, United States
William N. Wishard Memorial Hospital, Indianapolis, Indiana, United States
Howard Community Hospital, Kokomo, Indiana, United States
Center for Cancer Therapy at LaPorte Hospital and Health Services, La Porte, Indiana, United States
Clarian Arnett Cancer Care, Lafayette, Indiana, United States
Saint Anthony Memorial Health Centers, Michigan City, Indiana, United States
Medical Consultants, PC at Ball Memorial Cancer Center, Muncie, Indiana, United States
Community Hospital, Munster, Indiana, United States
Reid Hospital & Health Care Services, Richmond, Indiana, United States
CCOP - Northern Indiana CR Consortium, South Bend, Indiana, United States
Memorial Hospital of South Bend, South Bend, Indiana, United States
Saint Joseph Regional Medical Center, South Bend, Indiana, United States
South Bend Clinic, South Bend, Indiana, United States
McFarland Clinic, PC, Ames, Iowa, United States
Hematology Oncology Associates of the Quad Cities, Bettendorf, Iowa, United States
Iowa Blood and Cancer Care, Cedar Rapids, Iowa, United States
St. Luke's Hospital, Cedar Rapids, Iowa, United States
Mercy Regional Cancer Center at Mercy Medical Center, Cedar Rapids, Iowa, United States
Medical Oncology and Hematology Associates - West Des Moines, Clive, Iowa, United States
Heartland Oncology and Hematology, Council Bluffs, Iowa, United States
Genesis Regional Cancer Center at Genesis Medical Center, Davenport, Iowa, United States
Genesis Medical Center - West Campus, Davenport, Iowa, United States
Mercy Capitol Hospital, Des Moines, Iowa, United States
CCOP - Iowa Oncology Research Association, Des Moines, Iowa, United States
John Stoddard Cancer Center at Iowa Methodist Medical Center, Des Moines, Iowa, United States
Medical Oncology and Hematology Associates at John Stoddard Cancer Center, Des Moines, Iowa, United States
Medical Oncology and Hematology Associates at Mercy Cancer Center, Des Moines, Iowa, United States
Mercy Cancer Center at Mercy Medical Center - Des Moines, Des Moines, Iowa, United States
John Stoddard Cancer Center at Iowa Lutheran Hospital, Des Moines, Iowa, United States
McCreery Cancer Center at Ottumwa Regional, Ottumwa, Iowa, United States
Siouxland Hematology-Oncology Associates, LLP, Sioux City, Iowa, United States
Mercy Medical Center - Sioux City, Sioux City, Iowa, United States
St. Luke's Regional Medical Center, Sioux City, Iowa, United States
Cedar Valley Medical Specialists, PC - West Ridgeway Avenue, Waterloo, Iowa, United States
Covenant Cancer Treatment Center, Waterloo, Iowa, United States
Hospital District Sixth of Harper County, Anthony, Kansas, United States
Cancer Center of Kansas, PA - Chanute, Chanute, Kansas, United States
Cancer Center of Kansas, PA - Dodge City, Dodge City, Kansas, United States
Cancer Center of Kansas, PA - El Dorado, El Dorado, Kansas, United States
Cancer Center of Kansas - Fort Scott, Fort Scott, Kansas, United States
Cancer Center of Kansas-Independence, Independence, Kansas, United States
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center, Kansas City, Kansas, United States
Cancer Center of Kansas, PA - Kingman, Kingman, Kansas, United States
Lawrence Memorial Hospital, Lawrence, Kansas, United States
Southwest Medical Center, Liberal, Kansas, United States
Cancer Center of Kansas, PA - Newton, Newton, Kansas, United States
Menorah Medical Center, Overland Park, Kansas, United States
Saint Luke's Hospital - South, Overland Park, Kansas, United States
Cancer Center of Kansas, PA - Parsons, Parsons, Kansas, United States
Cancer Center of Kansas, PA - Pratt, Pratt, Kansas, United States
Cancer Center of Kansas, PA - Salina, Salina, Kansas, United States
Tammy Walker Cancer Center at Salina Regional Health Center, Salina, Kansas, United States
Shawnee Mission Medical Center, Shawnee Mission, Kansas, United States
Cotton-O'Neil Cancer Center, Topeka, Kansas, United States
St. Francis Comprehensive Cancer Center, Topeka, Kansas, United States
Cancer Center of Kansas, PA - Wellington, Wellington, Kansas, United States
Associates in Womens Health, PA - North Review, Wichita, Kansas, United States
Cancer Center of Kansas, PA - Medical Arts Tower, Wichita, Kansas, United States
Cancer Center of Kansas, PA - Wichita, Wichita, Kansas, United States
CCOP - Wichita, Wichita, Kansas, United States
Via Christi Cancer Center at Via Christi Regional Medical Center, Wichita, Kansas, United States
Cancer Center of Kansas, PA - Winfield, Winfield, Kansas, United States
James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky, United States
Pennington Cancer Center at Baton Rouge General, Baton Rouge, Louisiana, United States
Mary Bird Perkins Cancer Center - Baton Rouge, Baton Rouge, Louisiana, United States
MBCCOP - LSU Health Sciences Center, New Orleans, Louisiana, United States
Medical Center of Louisiana - New Orleans, New Orleans, Louisiana, United States
Highland Clinic, Shreveport, Louisiana, United States
Feist-Weiller Cancer Center at Louisiana State University Health Sciences, Shreveport, Louisiana, United States
Greater Baltimore Medical Center Cancer Center, Baltimore, Maryland, United States
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States
Shore Regional Cancer Center at Memorial Hospital - Easton, Easton, Maryland, United States
Union Hospital Cancer Program at Union Hospital, Elkton, Maryland, United States
Boston University Cancer Research Center, Boston, Massachusetts, United States
Lahey Clinic Medical Center - Burlington, Burlington, Massachusetts, United States
MetroWest Medical Center - Framingham Union Hospital, Framingham, Massachusetts, United States
Baystate Regional Cancer Program at D'Amour Center for Cancer Care, Springfield, Massachusetts, United States
Hickman Cancer Center at Bixby Medical Center, Adrian, Michigan, United States
Saint Joseph Mercy Cancer Center, Ann Arbor, Michigan, United States
CCOP - Michigan Cancer Research Consortium, Ann Arbor, Michigan, United States
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States
Battle Creek Health System Cancer Care Center, Battle Creek, Michigan, United States
Mecosta County Medical Center, Big Rapids, Michigan, United States
Oakwood Cancer Center at Oakwood Hospital and Medical Center, Dearborn, Michigan, United States
Josephine Ford Cancer Center at Henry Ford Hospital, Detroit, Michigan, United States
Green Bay Oncology, Limited - Escanaba, Escanaba, Michigan, United States
Genesys Hurley Cancer Institute, Flint, Michigan, United States
Hurley Medical Center, Flint, Michigan, United States
Butterworth Hospital at Spectrum Health, Grand Rapids, Michigan, United States
CCOP - Grand Rapids, Grand Rapids, Michigan, United States
Lacks Cancer Center at Saint Mary's Health Care, Grand Rapids, Michigan, United States
Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods, Michigan, United States
Dickinson County Healthcare System, Iron Mountain, Michigan, United States
Foote Memorial Hospital, Jackson, Michigan, United States
Borgess Medical Center, Kalamazoo, Michigan, United States
West Michigan Cancer Center, Kalamazoo, Michigan, United States
Bronson Methodist Hospital, Kalamazoo, Michigan, United States
Haematology-Oncology Associates of Ohio and Michigan, PC, Lambertville, Michigan, United States
Sparrow Regional Cancer Center, Lansing, Michigan, United States
St. Mary Mercy Hospital, Livonia, Michigan, United States
Upper Michigan Cancer Center at Marquette General Hospital, Marquette, Michigan, United States
Community Cancer Center of Monroe, Monroe, Michigan, United States
Mercy Memorial Hospital - Monroe, Monroe, Michigan, United States
Clemens Regional Medical Center, Mount Clemens, Michigan, United States
Mercy General Health Partners, Muskegon, Michigan, United States
St. Joseph Mercy Oakland, Pontiac, Michigan, United States
Mercy Regional Cancer Center at Mercy Hospital, Port Huron, Michigan, United States
Seton Cancer Institute at Saint Mary's - Saginaw, Saginaw, Michigan, United States
Lakeland Regional Cancer Care Center - St. Joseph, Saint Joseph, Michigan, United States
Providence Cancer Institute at Providence Hospital - Southfield Campus, Southfield, Michigan, United States
Munson Medical Center, Traverse City, Michigan, United States
St. John Macomb Hospital, Warren, Michigan, United States
Metro Health Hospital, Wyoming, Michigan, United States
MeritCare Bemidji, Bemidji, Minnesota, United States
Fairview Ridges Hospital, Burnsville, Minnesota, United States
Mercy and Unity Cancer Center at Mercy Hospital, Coon Rapids, Minnesota, United States
Duluth Clinic Cancer Center - Duluth, Duluth, Minnesota, United States
CCOP - Duluth, Duluth, Minnesota, United States
Miller - Dwan Medical Center, Duluth, Minnesota, United States
Fairview Southdale Hospital, Edina, Minnesota, United States
Fergus Falls Medical Group, PA, Fergus Falls, Minnesota, United States
Mercy and Unity Cancer Center at Unity Hospital, Fridley, Minnesota, United States
Minnesota Oncology Hematology, PA - Maplewood, Maplewood, Minnesota, United States
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital, Minneapolis, Minnesota, United States
Veterans Affairs Medical Center - Minneapolis, Minneapolis, Minnesota, United States
Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center, Robbinsdale, Minnesota, United States
Mayo Clinic Cancer Center, Rochester, Minnesota, United States
CentraCare Clinic - River Campus, Saint Cloud, Minnesota, United States
Coborn Cancer Center, Saint Cloud, Minnesota, United States
CCOP - Metro-Minnesota, Saint Louis Park, Minnesota, United States
Park Nicollet Cancer Center, Saint Louis Park, Minnesota, United States
United Hospital, Saint Paul, Minnesota, United States
St. Francis Cancer Center at St. Francis Medical Center, Shakopee, Minnesota, United States
Ridgeview Medical Center, Waconia, Minnesota, United States
Willmar Cancer Center at Rice Memorial Hospital, Willmar, Minnesota, United States
Minnesota Oncology Hematology, PA - Woodbury, Woodbury, Minnesota, United States
University of Mississippi Cancer Clinic, Jackson, Mississippi, United States
Veterans Affairs Medical Center - Jackson, Jackson, Mississippi, United States
Regional Cancer Center at Singing River Hospital, Pascagoula, Mississippi, United States
Saint Francis Medical Center, Cape Girardeau, Missouri, United States
Saint Luke's Hospital, Chesterfield, Missouri, United States
Independence Regional Health Center, Independence, Missouri, United States
Freeman Cancer Institute at Freeman Health System, Joplin, Missouri, United States
Truman Medical Center - Hospital Hill, Kansas City, Missouri, United States
Saint Luke's Cancer Institute at Saint Luke's Hospital, Kansas City, Missouri, United States
St. Joseph Medical Center, Kansas City, Missouri, United States
North Kansas City Hospital, Kansas City, Missouri, United States
Parvin Radiation Oncology, Kansas City, Missouri, United States
Heartland Hematology Oncology Associates, Incorporated, Kansas City, Missouri, United States
Veterans Affairs Medical Center - Kansas City, Kansas City, Missouri, United States
CCOP - Kansas City, Kansas City, Missouri, United States
Research Medical Center, Kansas City, Missouri, United States
Saint Luke's East - Lee's Summit, Lee's Summit, Missouri, United States
Liberty Hospital, Liberty, Missouri, United States
Heartland Regional Medical Center, Saint Joseph, Missouri, United States
Midwest Hematology Oncology Group, Incorporated, Saint Louis, Missouri, United States
Missouri Baptist Cancer Center, Saint Louis, Missouri, United States
Arch Medical Services, Incorporated at Center for Cancer Care and Research, Saint Louis, Missouri, United States
CCOP - St. Louis-Cape Girardeau, Saint Louis, Missouri, United States
David C. Pratt Cancer Center at St. John's Mercy, Saint Louis, Missouri, United States
CCOP - Montana Cancer Consortium, Billings, Montana, United States
Hematology-Oncology Centers of the Northern Rockies - Billings, Billings, Montana, United States
Northern Rockies Radiation Oncology Center, Billings, Montana, United States
St. Vincent Healthcare Cancer Care Services, Billings, Montana, United States
Billings Clinic - Downtown, Billings, Montana, United States
Bozeman Deaconess Cancer Center, Bozeman, Montana, United States
St. James Healthcare Cancer Care, Butte, Montana, United States
Big Sky Oncology, Great Falls, Montana, United States
Frontier Cancer Center, Great Falls, Montana, United States
Great Falls Clinic - Main Facility, Great Falls, Montana, United States
Sletten Cancer Institute at Benefis Healthcare, Great Falls, Montana, United States
Northern Montana Hospital, Havre, Montana, United States
St. Peter's Hospital, Helena, Montana, United States
Glacier Oncology, PLLC, Kalispell, Montana, United States
Kalispell Medical Oncology at KRMC, Kalispell, Montana, United States
Kalispell Regional Medical Center, Kalispell, Montana, United States
Community Medical Center, Missoula, Montana, United States
Guardian Oncology and Center for Wellness, Missoula, Montana, United States
Montana Cancer Specialists at Montana Cancer Center, Missoula, Montana, United States
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center, Missoula, Montana, United States
Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center, Grand Island, Nebraska, United States
Good Samaritan Cancer Center at Good Samaritan Hospital, Kearney, Nebraska, United States
Callahan Cancer Center at Great Plains Regional Medical Center, North Platte, Nebraska, United States
UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha, Nebraska, United States
University Medical Center of Southern Nevada, Las Vegas, Nevada, United States
CCOP - Nevada Cancer Research Foundation, Las Vegas, Nevada, United States
Nevada Cancer Institute, Las Vegas, Nevada, United States
Renown Institute for Cancer at Renown Regional Medical Center, Reno, Nevada, United States
New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care, Concord, New Hampshire, United States
Center for Cancer Care at Exeter Hospital, Exeter, New Hampshire, United States
New Hampshire Oncology - Hematology, PA - Hooksett, Hooksett, New Hampshire, United States
Lakes Region General Hospital, Laconia, New Hampshire, United States
Veterans Affairs Medical Center - East Orange, East Orange, New Jersey, United States
Hunterdon Regional Cancer Center at Hunterdon Medical Center, Flemington, New Jersey, United States
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton, Marlton, New Jersey, United States
Jersey Shore Cancer Center at Jersey Shore University Medical Center, Neptune, New Jersey, United States
Valley Hospital - Ridgewood, Ridgewood, New Jersey, United States
Somerset Medical Center, Somerville, New Jersey, United States
Frederick R. and Betty M. Smith Cancer Treatment Center, Sparta, New Jersey, United States
Cancer Institute of New Jersey at Cooper - Voorhees, Voorhees, New Jersey, United States
Fox Chase Virtua Health Cancer Program at Virtua West Jersey, Voorhees, New Jersey, United States
Our Lady of Mercy Medical Center Comprehensive Cancer Center, Bronx, New York, United States
Veterans Affairs Medical Center - Brooklyn, Brooklyn, New York, United States
Veterans Affairs Medical Center - Buffalo, Buffalo, New York, United States
Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital, Cooperstown, New York, United States
CCOP - Hematology-Oncology Associates of Central New York, East Syracuse, New York, United States
Falck Cancer Center at Arnot Ogden Medical Center, Elmira, New York, United States
Northern Westchester Hospital, Mount Kisco, New York, United States
New York Weill Cornell Cancer Center at Cornell University, New York, New York, United States
Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center, New York, New York, United States
Interlakes Oncology/Hematology PC, Rochester, New York, United States
James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester, New York, United States
Nalitt Cancer Institute at Staten Island University Hospital, Staten Island, New York, United States
Stony Brook University Cancer Center, Stony Brook, New York, United States
SUNY Upstate Medical University Hospital, Syracuse, New York, United States
Veterans Affairs Medical Center - Syracuse, Syracuse, New York, United States
Randolph Hospital, Asheboro, North Carolina, United States
Mission Hospitals - Memorial Campus, Asheville, North Carolina, United States
Alamance Cancer Center at Alamance Regional Medical Center, Burlington, North Carolina, United States
Presbyterian Cancer Center at Presbyterian Hospital, Charlotte, North Carolina, United States
Veterans Affairs Medical Center - Durham, Durham, North Carolina, United States
Southeastern Medical Oncology Center - Goldsboro, Goldsboro, North Carolina, United States
Wayne Memorial Hospital, Incorporated, Goldsboro, North Carolina, United States
Moses Cone Regional Cancer Center at Wesley Long Community Hospital, Greensboro, North Carolina, United States
Kinston Medical Specialists, Kinston, North Carolina, United States
Annie Penn Cancer Center, Reidsville, North Carolina, United States
Rutherford Hospital, Rutherfordton, North Carolina, United States
Marion L. Shepard Cancer Center at Beaufort County Hospital, Washington, North Carolina, United States
Bismarck Cancer Center, Bismarck, North Dakota, United States
Medcenter One Hospital Cancer Care Center, Bismarck, North Dakota, United States
Mid Dakota Clinic, PC, Bismarck, North Dakota, United States
St. Alexius Medical Center Cancer Center, Bismarck, North Dakota, United States
Dakota Cancer Institute at Dakota Clinic - South University, Fargo, North Dakota, United States
CCOP - MeritCare Hospital, Fargo, North Dakota, United States
MeritCare Broadway, Fargo, North Dakota, United States
Trinity CancerCare Center, Minot, North Dakota, United States
McDowell Cancer Center at Akron General Medical Center, Akron, Ohio, United States
Wood County Oncology Center, Bowling Green, Ohio, United States
Veterans Affairs Medical Center - Cincinnati, Cincinnati, Ohio, United States
Charles M. Barrett Cancer Center at University Hospital, Cincinnati, Ohio, United States
MetroHealth Cancer Care Center at MetroHealth Medical Center, Cleveland, Ohio, United States
North Coast Cancer Care - Clyde, Clyde, Ohio, United States
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States
Grandview Hospital, Dayton, Ohio, United States
Good Samaritan Hospital, Dayton, Ohio, United States
David L. Rike Cancer Center at Miami Valley Hospital, Dayton, Ohio, United States
Samaritan North Cancer Care Center, Dayton, Ohio, United States
CCOP - Dayton, Dayton, Ohio, United States
Veterans Affairs Medical Center - Dayton, Dayton, Ohio, United States
Hematology Oncology Center, Elyria, Ohio, United States
Blanchard Valley Medical Associates, Findlay, Ohio, United States
Middletown Regional Hospital, Franklin, Ohio, United States
Wayne Hospital, Greenville, Ohio, United States
Charles F. Kettering Memorial Hospital, Kettering, Ohio, United States
St. Rita's Medical Center, Lima, Ohio, United States
Northwest Ohio Oncology Center, Maumee, Ohio, United States
St. Luke's Hospital, Maumee, Ohio, United States
Fisher-Titus Medical Center, Norwalk, Ohio, United States
St. Charles Mercy Hospital, Oregon, Ohio, United States
Toledo Clinic - Oregon, Oregon, Ohio, United States
North Coast Cancer Care, Incorporated, Sandusky, Ohio, United States
Flower Hospital Cancer Center, Sylvania, Ohio, United States
Mercy Hospital of Tiffin, Tiffin, Ohio, United States
Toledo Hospital, Toledo, Ohio, United States
St. Vincent Mercy Medical Center, Toledo, Ohio, United States
Medical University of Ohio Cancer Center, Toledo, Ohio, United States
CCOP - Toledo Community Hospital, Toledo, Ohio, United States
St. Anne Mercy Hospital, Toledo, Ohio, United States
Toledo Clinic, Incorporated - Main Clinic, Toledo, Ohio, United States
UVMC Cancer Care Center at Upper Valley Medical Center, Troy, Ohio, United States
Fulton County Health Center, Wauseon, Ohio, United States
Clinton Memorial Hospital, Wilmington, Ohio, United States
United States Air Force Medical Center - Wright-Patterson, Wright-Patterson Air Force Base, Ohio, United States
Ruth G. McMillan Cancer Center at Greene Memorial Hospital, Xenia, Ohio, United States
Cleo Craig Cancer Research Clinic, Lawton, Oklahoma, United States
Bay Area Hospital, Coos Bay, Oregon, United States
Providence Milwaukie Hospital, Milwaukie, Oregon, United States
Providence Cancer Center at Providence Portland Medical Center, Portland, Oregon, United States
Adventist Medical Center, Portland, Oregon, United States
CCOP - Columbia River Oncology Program, Portland, Oregon, United States
Providence St. Vincent Medical Center, Portland, Oregon, United States
Kaiser Permanente Health Care - Portland, Portland, Oregon, United States
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest, Allentown, Pennsylvania, United States
Bryn Mawr Hospital, Bryn Mawr, Pennsylvania, United States
Geisinger Cancer Institute at Geisinger Health, Danville, Pennsylvania, United States
Easton Regional Cancer Center at Easton Hospital, Easton, Pennsylvania, United States
Geisinger Hazleton Cancer Center, Hazleton, Pennsylvania, United States
Cancer Center of Paoli Memorial Hospital, Paoli, Pennsylvania, United States
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia, Pennsylvania, United States
Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital, Pittsburgh, Pennsylvania, United States
Guthrie Cancer Center at Guthrie Clinic Sayre, Sayre, Pennsylvania, United States
Hematology and Oncology Associates of Northeastern Pennsylvania, Scranton, Pennsylvania, United States
Geisinger Medical Group - Scenery Park, State College, Pennsylvania, United States
Mount Nittany Medical Center, State College, Pennsylvania, United States
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center, Wilkes-Barre, Pennsylvania, United States
CCOP - Main Line Health, Wynnewood, Pennsylvania, United States
Lankenau Cancer Center at Lankenau Hospital, Wynnewood, Pennsylvania, United States
AnMed Cancer Center, Anderson, South Carolina, United States
Hollings Cancer Center at Medical University of South Carolina, Charleston, South Carolina, United States
McLeod Regional Medical Center, Florence, South Carolina, United States
CCOP - Upstate Carolina, Spartanburg, South Carolina, United States
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center, Spartanburg, South Carolina, United States
Oncology Services of Aberdeen, Aberdeen, South Dakota, United States
Rapid City Regional Hospital, Rapid City, South Dakota, United States
Avera Cancer Institute, Sioux Falls, South Dakota, United States
Medical X-Ray Center, PC, Sioux Falls, South Dakota, United States
Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls, South Dakota, United States
Cookeville Regional Medical Center, Cookeville, Tennessee, United States
Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center, Kingsport, Tennessee, United States
Thompson Cancer Survival Center, Knoxville, Tennessee, United States
University of Tennessee Cancer Institute - Memphis, Memphis, Tennessee, United States
Veterans Affairs Medical Center - Memphis, Memphis, Tennessee, United States
Harrington Cancer Center, Amarillo, Texas, United States
St. Joseph Regional Cancer Center, Bryan, Texas, United States
Veterans Affairs Medical Center - Dallas, Dallas, Texas, United States
Medical City Dallas Hospital, Dallas, Texas, United States
Brooke Army Medical Center, Fort Sam Houston, Texas, United States
Baylor University Medical Center - Houston, Houston, Texas, United States
Ben Taub General Hospital, Houston, Texas, United States
Methodist Hospital, Houston, Texas, United States
St. Luke's Texas Cancer Institute at St. Luke's Episcopal Hospital, Houston, Texas, United States
Veterans Affairs Medical Center - Houston, Houston, Texas, United States
Wilford Hall Medical Center, Lackland Air Force Base, Texas, United States
UMC Southwest Cancer and Research Center, Lubbock, Texas, United States
Veterans Affairs Medical Center - San Antonio (Murphy), San Antonio, Texas, United States
University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States
Cancer Therapy and Research Center, San Antonio, Texas, United States
University Hospital - San Antonio, San Antonio, Texas, United States
CCOP - Scott and White Hospital, Temple, Texas, United States
American Fork Hospital, American Fork, Utah, United States
Sandra L. Maxwell Cancer Center, Cedar City, Utah, United States
Logan Regional Hospital, Logan, Utah, United States
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center, Murray, Utah, United States
Val and Ann Browning Cancer Center at McKay-Dee Hospital Center, Ogden, Utah, United States
Utah Valley Regional Medical Center - Provo, Provo, Utah, United States
Dixie Regional Medical Center - East Campus, Saint George, Utah, United States
LDS Hospital, Salt Lake City, Utah, United States
Utah Cancer Specialists at UCS Cancer Center, Salt Lake City, Utah, United States
Huntsman Cancer Institute at University of Utah, Salt Lake City, Utah, United States
Green Mountain Oncology Group, Bennington, Vermont, United States
Danville Regional Medical Center, Danville, Virginia, United States
Fredericksburg Oncology, Incorporated, Fredericksburg, Virginia, United States
Riverside Middle Peninsula Cancer Center, Gloucester, Virginia, United States
Lynchburg Hematology-Oncology Clinic, Lynchburg, Virginia, United States
Peninsula Cancer Institute - Newport News Office, Newport News, Virginia, United States
Southwest Virginia Regional Cancer Center at Wellmonth Health, Norton, Virginia, United States
Veterans Affairs Medical Center - Richmond, Richmond, Virginia, United States
Virginia Commonwealth University Massey Cancer Center, Richmond, Virginia, United States
Peninsula Cancer Institute - Williamsburg Office, Williamsburg, Virginia, United States
Auburn Regional Center for Cancer Care, Auburn, Washington, United States
St. Joseph Cancer Center, Bellingham, Washington, United States
Olympic Hematology and Oncology, Bremerton, Washington, United States
Providence Centralia Hospital, Centralia, Washington, United States
St. Francis Hospital, Federal Way, Washington, United States
Columbia Basin Hematology, Kennewick, Washington, United States
Cascade Cancer Center at Evergreen Hospital Medical Center, Kirkland, Washington, United States
Providence St. Peter Hospital Regional Cancer Center, Olympia, Washington, United States
Harrison Poulsbo Hematology and Onocology, Poulsbo, Washington, United States
Good Samaritan Cancer Center, Puyallup, Washington, United States
Valley Medical Center, Renton, Washington, United States
CCOP - Virginia Mason Research Center, Seattle, Washington, United States
Harborview Medical Center, Seattle, Washington, United States
Minor and James Medical, PLLC, Seattle, Washington, United States
Pacific Medical Center, Seattle, Washington, United States
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
Group Health Central Hospital, Seattle, Washington, United States
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus, Seattle, Washington, United States
Polyclinic First Hill, Seattle, Washington, United States
University Cancer Center at University of Washington Medical Center, Seattle, Washington, United States
Cancer Care Northwest - Spokane South, Spokane, Washington, United States
Rockwood Clinic Cancer Treatment Center, Spokane, Washington, United States
Evergreen Hematology and Oncology, PS, Spokane, Washington, United States
Franciscan Cancer Center at St. Joseph Medical Center, Tacoma, Washington, United States
Allenmore Hospital, Tacoma, Washington, United States
CCOP - Northwest, Tacoma, Washington, United States
MultiCare Regional Cancer Center at Tacoma General Hospital, Tacoma, Washington, United States
St. Clare Hospital, Tacoma, Washington, United States
Southwest Washington Medical Center Cancer Center, Vancouver, Washington, United States
Wenatchee Valley Medical Center, Wenatchee, Washington, United States
West Virginia University Health Sciences Center - Charleston, Charleston, West Virginia, United States
Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital, Parkersburg, West Virginia, United States
Schiffler Cancer Center at Wheeling Hospital, Wheeling, West Virginia, United States
Langlade Memorial Hospital, Antigo, Wisconsin, United States
Fox Valley Hematology and Oncology - East Grant Street, Appleton, Wisconsin, United States
Marshfield Clinic - Chippewa Center, Chippewa Falls, Wisconsin, United States
Marshfield Clinic Cancer Care at Regional Cancer Center, Eau Claire, Wisconsin, United States
Vince Lombardi Cancer Center at Aurora Lakeland Medical Center - Elkhorn, Elkhorn, Wisconsin, United States
Oncology Alliance - Franklin, Franklin, Wisconsin, United States
Oncology Alliance, SC - Milwaukee - East, Glendale, Wisconsin, United States
Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center, Green Bay, Wisconsin, United States
Green Bay Oncology, Limited at St. Mary's Hospital, Green Bay, Wisconsin, United States
St. Mary's Hospital Medical Center - Green Bay, Green Bay, Wisconsin, United States
St. Vincent Hospital Regional Cancer Center, Green Bay, Wisconsin, United States
UW Cancer Center Johnson Creek, Johnson Creek, Wisconsin, United States
Oncology Alliance - Kenosha South, Kenosha, Wisconsin, United States
Gundersen Lutheran Center for Cancer and Blood, La Crosse, Wisconsin, United States
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Madison, Wisconsin, United States
Holy Family Memorial Medical Center Cancer Care Center, Manitowoc, Wisconsin, United States
Bay Area Cancer Care Center at Bay Area Medical Center, Marinette, Wisconsin, United States
Marshfield Clinic - Marshfield Center, Marshfield, Wisconsin, United States
Saint Joseph's Hospital, Marshfield, Wisconsin, United States
Medical Consultants, Limited, Milwaukee, Wisconsin, United States
Oncology Alliance, SC - Milwaukee - South, Milwaukee, Wisconsin, United States
Froedtert Hospital and Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Medical College of Wisconsin Cancer Center, Milwaukee, Wisconsin, United States
Marshfield Clinic - Lakeland Center, Minocqua, Wisconsin, United States
Green Bay Oncology, Limited - Oconto Falls, Oconto Falls, Wisconsin, United States
Ministry Medical Group at Saint Mary's Hospital, Rhinelander, Wisconsin, United States
Marshfield Clinic - Indianhead Center, Rice Lake, Wisconsin, United States
Saint Michael's Hospital Cancer Center, Stevens Point, Wisconsin, United States
Green Bay Oncology, Limited - Sturgeon Bay, Sturgeon Bay, Wisconsin, United States
Marshfield Clinic - Wausau Center, Wausau, Wisconsin, United States
University of Wisconcin Cancer Center at Aspirus Wausau Hospital, Wausau, Wisconsin, United States
Oncology Alliance, SC - Milwaukee - West, Wauwatosa, Wisconsin, United States
Marshfield Clinic - Weston Center, Weston, Wisconsin, United States
Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids, Wisconsin, United States
Riverview UW Cancer Center at Riverview Hospital, Wisconsin Rapids, Wisconsin, United States
Rocky Mountain Oncology, Casper, Wyoming, United States
Welch Cancer Center at Sheridan Memorial Hospital, Sheridan, Wyoming, United States
Contact Details
Name: David I. Quinn, MD
Affiliation: University of Southern California
Role: STUDY_CHAIR
Name: Maha Hadi A. Hussain, MD
Affiliation: University of Michigan Rogel Cancer Center
Role: STUDY_CHAIR
Name: Primo N. Lara, MD
Affiliation: University of California, Davis
Role: STUDY_CHAIR
Name: Mark Garzotto, MD
Affiliation: Portland VA Medical Center
Role: STUDY_CHAIR
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