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Spots Global Cancer Trial Database for Testing the Addition of Pembrolizumab, an Immunotherapy Cancer Drug to Olaparib Alone as Therapy for Patients With Pancreatic Cancer That Has Spread With Inherited BRCA Mutations

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Testing the Addition of Pembrolizumab, an Immunotherapy Cancer Drug to Olaparib Alone as Therapy for Patients With Pancreatic Cancer That Has Spread With Inherited BRCA Mutations

Official Title: Randomized Phase II Clinical Trial of Olaparib + Pembrolizumab vs. Olaparib Alone as Maintenance Therapy in Metastatic Pancreatic Cancer Patients With Germline BRCA1 or BRCA2 Mutations

Study ID: NCT04548752

Study Description

Brief Summary: This phase II trial studies whether adding pembrolizumab to olaparib (standard of care) works better than olaparib alone in treating patients with pancreatic cancer with germline BRCA1 or BRCA2 mutations that has spread to other places in the body (metastatic). BRCA1 and BRCA2 are human genes that produce tumor suppressor proteins. These proteins help repair damaged deoxyribonucleic acid (DNA) and, therefore, play a role in ensuring the stability of each cell's genetic material. When either of these genes is mutated, or altered, such that its protein product is not made or does not function correctly, DNA damage may not be repaired properly. As a result, cells are more likely to develop additional genetic alterations that can lead to some types of cancer, including pancreatic cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Olaparib is an inhibitor of PARP, a protein that helps repair damaged DNA. Blocking PARP may help keep tumor cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy. The addition of pembrolizumab to the usual treatment of olaparib may help to shrink tumors in patients with metastatic pancreatic cancer with BRCA1 or BRCA2 mutations.

Detailed Description: PRIMARY OBJECTIVE: I. To evaluate the progression free survival (PFS) of advanced pancreatic cancer patients with germline BRCA1 or BRCA2 mutations treated with olaparib + pembrolizumab compared to olaparib alone as maintenance therapy. SECONDARY OBJECTIVES: I. To evaluate the safety and tolerability associated with the combination of olaparib + pembrolizumab versus (vs.) olaparib alone as maintenance therapy. II. To evaluate the overall survival (OS) of patients treated with olaparib + pembrolizumab compared to olaparib alone as maintenance therapy. III. To evaluate the overall response rate (ORR) by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1, including confirmed and unconfirmed, complete and partial response, of patients treated with olaparib + pembrolizumab compared to olaparib alone, in the subset of patients with measurable disease. IV. To evaluate the duration of response (DoR) by RECIST 1.1 in patients treated with olaparib + pembrolizumab compared to olaparib alone. BANKING OBJECTIVE: I. To bank tissue and blood specimens for future correlative studies. OUTLINE: Patients are randomized to 1 of 2 arms. ARM A: Patients receive olaparib orally (PO) twice daily (BID) on days 1-21 and pembrolizumab intravenously (IV) over 30 minutes on day 1 of each cycle. Treatment repeats every 21 days for up to 18 cycles in the absence of disease progression or unacceptable toxicity. Beginning in cycle 19, patients receive olaparib PO BID on days 1-42 and pembrolizumab IV over 30 minutes on day 1 of each cycle. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity. ARM B: Patients receive olaparib PO BID on days 1-21 of each cycle. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients undergo computed tomography (CT) scan or magnetic resonance imaging (MRI), tumor biopsy and blood sample collection throughout the study. After completion of study treatment, patients are followed for 30 days and every 6 months for 3 years from the date of randomization.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Anchorage Associates in Radiation Medicine, Anchorage, Alaska, United States

Anchorage Radiation Therapy Center, Anchorage, Alaska, United States

Alaska Breast Care and Surgery LLC, Anchorage, Alaska, United States

Alaska Oncology and Hematology LLC, Anchorage, Alaska, United States

Alaska Women's Cancer Care, Anchorage, Alaska, United States

Anchorage Oncology Centre, Anchorage, Alaska, United States

Katmai Oncology Group, Anchorage, Alaska, United States

Providence Alaska Medical Center, Anchorage, Alaska, United States

Fairbanks Memorial Hospital, Fairbanks, Alaska, United States

Kingman Regional Medical Center, Kingman, Arizona, United States

Cancer Center at Saint Joseph's, Phoenix, Arizona, United States

Mercy Hospital Fort Smith, Fort Smith, Arkansas, United States

CHI Saint Vincent Cancer Center Hot Springs, Hot Springs, Arkansas, United States

Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande, California, United States

PCR Oncology, Arroyo Grande, California, United States

Sutter Auburn Faith Hospital, Auburn, California, United States

Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn, California, United States

Alta Bates Summit Medical Center-Herrick Campus, Berkeley, California, United States

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank, California, United States

Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park, California, United States

Eden Hospital Medical Center, Castro Valley, California, United States

Sutter Davis Hospital, Davis, California, United States

City of Hope Comprehensive Cancer Center, Duarte, California, United States

Palo Alto Medical Foundation-Fremont, Fremont, California, United States

City of Hope at Irvine Lennar, Irvine, California, United States

Memorial Medical Center, Modesto, California, United States

Palo Alto Medical Foundation-Camino Division, Mountain View, California, United States

Palo Alto Medical Foundation-Gynecologic Oncology, Mountain View, California, United States

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California, United States

Palo Alto Medical Foundation Health Care, Palo Alto, California, United States

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville, California, United States

Sutter Roseville Medical Center, Roseville, California, United States

Sutter Medical Center Sacramento, Sacramento, California, United States

California Pacific Medical Center-Pacific Campus, San Francisco, California, United States

Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo, California, United States

Mills Health Center, San Mateo, California, United States

Palo Alto Medical Foundation-Santa Cruz, Santa Cruz, California, United States

Mission Hope Medical Oncology - Santa Maria, Santa Maria, California, United States

Providence Medical Foundation - Santa Rosa, Santa Rosa, California, United States

Sutter Pacific Medical Foundation, Santa Rosa, California, United States

Providence Santa Rosa Memorial Hospital, Santa Rosa, California, United States

Palo Alto Medical Foundation-Sunnyvale, Sunnyvale, California, United States

Sutter Cancer Centers Radiation Oncology Services-Vacaville, Vacaville, California, United States

Sutter Solano Medical Center/Cancer Center, Vallejo, California, United States

Rocky Mountain Cancer Centers-Aurora, Aurora, Colorado, United States

The Medical Center of Aurora, Aurora, Colorado, United States

UCHealth University of Colorado Hospital, Aurora, Colorado, United States

Boulder Community Foothills Hospital, Boulder, Colorado, United States

Rocky Mountain Cancer Centers-Boulder, Boulder, Colorado, United States

Rocky Mountain Cancer Centers - Centennial, Centennial, Colorado, United States

Penrose-Saint Francis Healthcare, Colorado Springs, Colorado, United States

Rocky Mountain Cancer Centers-Penrose, Colorado Springs, Colorado, United States

The Women's Imaging Center, Denver, Colorado, United States

Porter Adventist Hospital, Denver, Colorado, United States

Colorado Blood Cancer Institute, Denver, Colorado, United States

Presbyterian - Saint Lukes Medical Center - Health One, Denver, Colorado, United States

Rocky Mountain Cancer Centers-Midtown, Denver, Colorado, United States

Rocky Mountain Cancer Centers-Rose, Denver, Colorado, United States

Rose Medical Center, Denver, Colorado, United States

Western Surgical Care, Denver, Colorado, United States

Mercy Medical Center, Durango, Colorado, United States

Southwest Oncology PC, Durango, Colorado, United States

Mountain Blue Cancer Care Center - Swedish, Englewood, Colorado, United States

Rocky Mountain Cancer Centers - Swedish, Englewood, Colorado, United States

Swedish Medical Center, Englewood, Colorado, United States

The Melanoma and Skin Cancer Institute, Englewood, Colorado, United States

Poudre Valley Hospital, Fort Collins, Colorado, United States

Cancer Care and Hematology-Fort Collins, Fort Collins, Colorado, United States

Banner North Colorado Medical Center, Greeley, Colorado, United States

UCHealth Greeley Hospital, Greeley, Colorado, United States

UCHealth Highlands Ranch Hospital, Highlands Ranch, Colorado, United States

Rocky Mountain Cancer Centers-Lakewood, Lakewood, Colorado, United States

Saint Anthony Hospital, Lakewood, Colorado, United States

Rocky Mountain Cancer Centers-Littleton, Littleton, Colorado, United States

Littleton Adventist Hospital, Littleton, Colorado, United States

Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree, Colorado, United States

Sky Ridge Medical Center, Lone Tree, Colorado, United States

Longmont United Hospital, Longmont, Colorado, United States

Rocky Mountain Cancer Centers-Longmont, Longmont, Colorado, United States

Medical Center of the Rockies, Loveland, Colorado, United States

Banner McKee Medical Center, Loveland, Colorado, United States

Parker Adventist Hospital, Parker, Colorado, United States

Saint Mary Corwin Medical Center, Pueblo, Colorado, United States

Rocky Mountain Cancer Centers-Thornton, Thornton, Colorado, United States

Danbury Hospital, Danbury, Connecticut, United States

Smilow Cancer Hospital Care Center at Greenwich, Greenwich, Connecticut, United States

Yale University, New Haven, Connecticut, United States

Yale-New Haven Hospital North Haven Medical Center, North Haven, Connecticut, United States

Norwalk Hospital, Norwalk, Connecticut, United States

Beebe South Coastal Health Campus, Frankford, Delaware, United States

Helen F Graham Cancer Center, Newark, Delaware, United States

Medical Oncology Hematology Consultants PA, Newark, Delaware, United States

Beebe Health Campus, Rehoboth Beach, Delaware, United States

Sibley Memorial Hospital, Washington, District of Columbia, United States

Mount Sinai Comprehensive Cancer Center at Aventura, Aventura, Florida, United States

Holy Cross Hospital, Fort Lauderdale, Florida, United States

Mount Sinai Medical Center, Miami Beach, Florida, United States

Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho, United States

Saint Luke's Cancer Institute - Boise, Boise, Idaho, United States

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell, Idaho, United States

Kootenai Health - Coeur d'Alene, Coeur d'Alene, Idaho, United States

Walter Knox Memorial Hospital, Emmett, Idaho, United States

Saint Luke's Cancer Institute - Fruitland, Fruitland, Idaho, United States

Idaho Urologic Institute-Meridian, Meridian, Idaho, United States

Saint Luke's Cancer Institute - Meridian, Meridian, Idaho, United States

Saint Luke's Cancer Institute - Nampa, Nampa, Idaho, United States

Saint Alphonsus Cancer Care Center-Nampa, Nampa, Idaho, United States

Kootenai Clinic Cancer Services - Post Falls, Post Falls, Idaho, United States

Kootenai Cancer Clinic, Sandpoint, Idaho, United States

Saint Luke's Cancer Institute - Twin Falls, Twin Falls, Idaho, United States

Saint Anthony's Health, Alton, Illinois, United States

Rush - Copley Medical Center, Aurora, Illinois, United States

Illinois CancerCare-Bloomington, Bloomington, Illinois, United States

Illinois CancerCare-Canton, Canton, Illinois, United States

Memorial Hospital of Carbondale, Carbondale, Illinois, United States

SIH Cancer Institute, Carterville, Illinois, United States

Illinois CancerCare-Carthage, Carthage, Illinois, United States

Centralia Oncology Clinic, Centralia, Illinois, United States

Northwestern University, Chicago, Illinois, United States

Carle at The Riverfront, Danville, Illinois, United States

Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois, United States

Decatur Memorial Hospital, Decatur, Illinois, United States

Illinois CancerCare-Dixon, Dixon, Illinois, United States

Carle Physician Group-Effingham, Effingham, Illinois, United States

Crossroads Cancer Center, Effingham, Illinois, United States

Illinois CancerCare-Eureka, Eureka, Illinois, United States

Illinois CancerCare-Galesburg, Galesburg, Illinois, United States

Western Illinois Cancer Treatment Center, Galesburg, Illinois, United States

Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois, United States

Northwestern Medicine Lake Forest Hospital, Lake Forest, Illinois, United States

Illinois CancerCare-Macomb, Macomb, Illinois, United States

Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois, United States

Good Samaritan Regional Health Center, Mount Vernon, Illinois, United States

Cancer Care Center of O'Fallon, O'Fallon, Illinois, United States

Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois, United States

Illinois CancerCare-Pekin, Pekin, Illinois, United States

Illinois CancerCare-Peoria, Peoria, Illinois, United States

Methodist Medical Center of Illinois, Peoria, Illinois, United States

Illinois CancerCare-Peru, Peru, Illinois, United States

Valley Radiation Oncology, Peru, Illinois, United States

Illinois CancerCare-Princeton, Princeton, Illinois, United States

Southern Illinois University School of Medicine, Springfield, Illinois, United States

Springfield Clinic, Springfield, Illinois, United States

Memorial Medical Center, Springfield, Illinois, United States

Carle Cancer Center, Urbana, Illinois, United States

The Carle Foundation Hospital, Urbana, Illinois, United States

Illinois CancerCare - Washington, Washington, Illinois, United States

Rush-Copley Healthcare Center, Yorkville, Illinois, United States

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, United States

Reid Health, Richmond, Indiana, United States

Mary Greeley Medical Center, Ames, Iowa, United States

McFarland Clinic - Ames, Ames, Iowa, United States

Mission Cancer and Blood - Ankeny, Ankeny, Iowa, United States

McFarland Clinic - Boone, Boone, Iowa, United States

Saint Anthony Regional Hospital, Carroll, Iowa, United States

Mercy Cancer Center-West Lakes, Clive, Iowa, United States

Mission Cancer and Blood - West Des Moines, Clive, Iowa, United States

Alegent Health Mercy Hospital, Council Bluffs, Iowa, United States

Heartland Oncology and Hematology LLP, Council Bluffs, Iowa, United States

Methodist Jennie Edmundson Hospital, Council Bluffs, Iowa, United States

Greater Regional Medical Center, Creston, Iowa, United States

Iowa Methodist Medical Center, Des Moines, Iowa, United States

Mission Cancer and Blood - Des Moines, Des Moines, Iowa, United States

Broadlawns Medical Center, Des Moines, Iowa, United States

Mercy Medical Center - Des Moines, Des Moines, Iowa, United States

Mission Cancer and Blood - Laurel, Des Moines, Iowa, United States

Iowa Lutheran Hospital, Des Moines, Iowa, United States

McFarland Clinic - Trinity Cancer Center, Fort Dodge, Iowa, United States

Trinity Regional Medical Center, Fort Dodge, Iowa, United States

McFarland Clinic - Jefferson, Jefferson, Iowa, United States

McFarland Clinic - Marshalltown, Marshalltown, Iowa, United States

Methodist West Hospital, West Des Moines, Iowa, United States

Mercy Medical Center-West Lakes, West Des Moines, Iowa, United States

Central Care Cancer Center - Garden City, Garden City, Kansas, United States

Central Care Cancer Center - Great Bend, Great Bend, Kansas, United States

Flaget Memorial Hospital, Bardstown, Kentucky, United States

Commonwealth Cancer Center-Corbin, Corbin, Kentucky, United States

Saint Joseph Radiation Oncology Resource Center, Lexington, Kentucky, United States

Saint Joseph Hospital East, Lexington, Kentucky, United States

Saint Joseph London, London, Kentucky, United States

Jewish Hospital, Louisville, Kentucky, United States

Saints Mary and Elizabeth Hospital, Louisville, Kentucky, United States

UofL Health Medical Center Northeast, Louisville, Kentucky, United States

Jewish Hospital Medical Center South, Shepherdsville, Kentucky, United States

Hickman Cancer Center, Adrian, Michigan, United States

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan, United States

University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States

Bronson Battle Creek, Battle Creek, Michigan, United States

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton, Michigan, United States

Trinity Health Medical Center - Brighton, Brighton, Michigan, United States

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton, Michigan, United States

Trinity Health Medical Center - Canton, Canton, Michigan, United States

Caro Cancer Center, Caro, Michigan, United States

Saint Joseph Mercy Chelsea, Chelsea, Michigan, United States

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea, Michigan, United States

Hematology Oncology Consultants-Clarkston, Clarkston, Michigan, United States

Newland Medical Associates-Clarkston, Clarkston, Michigan, United States

Henry Ford Macomb Hospital-Clinton Township, Clinton Township, Michigan, United States

Wayne State University/Karmanos Cancer Institute, Detroit, Michigan, United States

Henry Ford Hospital, Detroit, Michigan, United States

Ascension Saint John Hospital, Detroit, Michigan, United States

Great Lakes Cancer Management Specialists-Doctors Park, East China Township, Michigan, United States

Weisberg Cancer Treatment Center, Farmington Hills, Michigan, United States

Genesee Cancer and Blood Disease Treatment Center, Flint, Michigan, United States

Genesee Hematology Oncology PC, Flint, Michigan, United States

Genesys Hurley Cancer Institute, Flint, Michigan, United States

Hurley Medical Center, Flint, Michigan, United States

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan, United States

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan, United States

Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan, United States

Academic Hematology Oncology Specialists, Grosse Pointe Woods, Michigan, United States

Great Lakes Cancer Management Specialists-Van Elslander Cancer Center, Grosse Pointe Woods, Michigan, United States

Michigan Breast Specialists-Grosse Pointe Woods, Grosse Pointe Woods, Michigan, United States

Bronson Methodist Hospital, Kalamazoo, Michigan, United States

West Michigan Cancer Center, Kalamazoo, Michigan, United States

Ascension Borgess Cancer Center, Kalamazoo, Michigan, United States

Borgess Medical Center, Kalamazoo, Michigan, United States

University of Michigan Health - Sparrow Lansing, Lansing, Michigan, United States

Hope Cancer Clinic, Livonia, Michigan, United States

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan, United States

Great Lakes Cancer Management Specialists-Macomb Medical Campus, Macomb, Michigan, United States

Michigan Breast Specialists-Macomb Township, Macomb, Michigan, United States

Saint Mary's Oncology/Hematology Associates of Marlette, Marlette, Michigan, United States

Toledo Clinic Cancer Centers-Monroe, Monroe, Michigan, United States

Trinity Health Muskegon Hospital, Muskegon, Michigan, United States

Corewell Health Lakeland Hospitals - Niles Hospital, Niles, Michigan, United States

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores, Michigan, United States

Ascension Providence Hospitals - Novi, Novi, Michigan, United States

Hope Cancer Center, Pontiac, Michigan, United States

Michigan Healthcare Professionals Pontiac, Pontiac, Michigan, United States

Newland Medical Associates-Pontiac, Pontiac, Michigan, United States

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac, Michigan, United States

Corewell Health Reed City Hospital, Reed City, Michigan, United States

Ascension Saint Mary's Hospital, Saginaw, Michigan, United States

Oncology Hematology Associates of Saginaw Valley PC, Saginaw, Michigan, United States

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph, Michigan, United States

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph, Michigan, United States

Ascension Providence Hospitals - Southfield, Southfield, Michigan, United States

Bhadresh Nayak MD PC-Sterling Heights, Sterling Heights, Michigan, United States

Ascension Saint Joseph Hospital, Tawas City, Michigan, United States

Munson Medical Center, Traverse City, Michigan, United States

Advanced Breast Care Center PLLC, Warren, Michigan, United States

Great Lakes Cancer Management Specialists-Macomb Professional Building, Warren, Michigan, United States

Macomb Hematology Oncology PC, Warren, Michigan, United States

Michigan Breast Specialists-Warren, Warren, Michigan, United States

Saint John Macomb-Oakland Hospital, Warren, Michigan, United States

Saint Mary's Oncology/Hematology Associates of West Branch, West Branch, Michigan, United States

University of Michigan Health - West, Wyoming, Michigan, United States

Huron Gastroenterology PC, Ypsilanti, Michigan, United States

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti, Michigan, United States

Sanford Joe Lueken Cancer Center, Bemidji, Minnesota, United States

Fairview Ridges Hospital, Burnsville, Minnesota, United States

Minnesota Oncology - Burnsville, Burnsville, Minnesota, United States

Cambridge Medical Center, Cambridge, Minnesota, United States

Mercy Hospital, Coon Rapids, Minnesota, United States

Fairview Southdale Hospital, Edina, Minnesota, United States

Unity Hospital, Fridley, Minnesota, United States

Fairview Clinics and Surgery Center Maple Grove, Maple Grove, Minnesota, United States

Minnesota Oncology Hematology PA-Maplewood, Maplewood, Minnesota, United States

Saint John's Hospital - Healtheast, Maplewood, Minnesota, United States

Abbott-Northwestern Hospital, Minneapolis, Minnesota, United States

Hennepin County Medical Center, Minneapolis, Minnesota, United States

Health Partners Inc, Minneapolis, Minnesota, United States

Monticello Cancer Center, Monticello, Minnesota, United States

New Ulm Medical Center, New Ulm, Minnesota, United States

Fairview Northland Medical Center, Princeton, Minnesota, United States

North Memorial Medical Health Center, Robbinsdale, Minnesota, United States

Mayo Clinic in Rochester, Rochester, Minnesota, United States

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota, United States

Regions Hospital, Saint Paul, Minnesota, United States

United Hospital, Saint Paul, Minnesota, United States

Saint Francis Regional Medical Center, Shakopee, Minnesota, United States

Lakeview Hospital, Stillwater, Minnesota, United States

Ridgeview Medical Center, Waconia, Minnesota, United States

Rice Memorial Hospital, Willmar, Minnesota, United States

Minnesota Oncology Hematology PA-Woodbury, Woodbury, Minnesota, United States

Fairview Lakes Medical Center, Wyoming, Minnesota, United States

Baptist Memorial Hospital and Cancer Center-Golden Triangle, Columbus, Mississippi, United States

Baptist Cancer Center-Grenada, Grenada, Mississippi, United States

Baptist Memorial Hospital and Cancer Center-Oxford, Oxford, Mississippi, United States

Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven, Mississippi, United States

Saint Louis Cancer and Breast Institute-Ballwin, Ballwin, Missouri, United States

Central Care Cancer Center - Bolivar, Bolivar, Missouri, United States

Saint Francis Medical Center, Cape Girardeau, Missouri, United States

Southeast Cancer Center, Cape Girardeau, Missouri, United States

Parkland Health Center - Farmington, Farmington, Missouri, United States

MU Health Care Goldschmidt Cancer Center, Jefferson City, Missouri, United States

Freeman Health System, Joplin, Missouri, United States

Mercy Hospital Joplin, Joplin, Missouri, United States

Delbert Day Cancer Institute at PCRMC, Rolla, Missouri, United States

Mercy Clinic-Rolla-Cancer and Hematology, Rolla, Missouri, United States

Heartland Regional Medical Center, Saint Joseph, Missouri, United States

Saint Louis Cancer and Breast Institute-South City, Saint Louis, Missouri, United States

Mercy Hospital South, Saint Louis, Missouri, United States

Missouri Baptist Medical Center, Saint Louis, Missouri, United States

Mercy Hospital Saint Louis, Saint Louis, Missouri, United States

Sainte Genevieve County Memorial Hospital, Sainte Genevieve, Missouri, United States

Mercy Hospital Springfield, Springfield, Missouri, United States

CoxHealth South Hospital, Springfield, Missouri, United States

Missouri Baptist Sullivan Hospital, Sullivan, Missouri, United States

BJC Outpatient Center at Sunset Hills, Sunset Hills, Missouri, United States

Mercy Hospital Washington, Washington, Missouri, United States

Community Hospital of Anaconda, Anaconda, Montana, United States

Billings Clinic Cancer Center, Billings, Montana, United States

Bozeman Health Deaconess Hospital, Bozeman, Montana, United States

Benefis Sletten Cancer Institute, Great Falls, Montana, United States

Great Falls Clinic, Great Falls, Montana, United States

Kalispell Regional Medical Center, Kalispell, Montana, United States

Saint Patrick Hospital - Community Hospital, Missoula, Montana, United States

Community Medical Center, Missoula, Montana, United States

Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island, Nebraska, United States

CHI Health Good Samaritan, Kearney, Nebraska, United States

Saint Elizabeth Regional Medical Center, Lincoln, Nebraska, United States

Nebraska Cancer Specialists/Oncology Hematology West PC - MECC, Omaha, Nebraska, United States

Nebraska Methodist Hospital, Omaha, Nebraska, United States

Oncology Associates PC, Omaha, Nebraska, United States

Alegent Health Immanuel Medical Center, Omaha, Nebraska, United States

Alegent Health Bergan Mercy Medical Center, Omaha, Nebraska, United States

Alegent Health Lakeside Hospital, Omaha, Nebraska, United States

Creighton University Medical Center, Omaha, Nebraska, United States

Midlands Community Hospital, Papillion, Nebraska, United States

Carson Tahoe Regional Medical Center, Carson City, Nevada, United States

Cancer and Blood Specialists-Henderson, Henderson, Nevada, United States

Comprehensive Cancer Centers of Nevada - Henderson, Henderson, Nevada, United States

Comprehensive Cancer Centers of Nevada-Horizon Ridge, Henderson, Nevada, United States

Las Vegas Cancer Center-Henderson, Henderson, Nevada, United States

OptumCare Cancer Care at Seven Hills, Henderson, Nevada, United States

Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson, Nevada, United States

GenesisCare USA - Henderson, Henderson, Nevada, United States

Las Vegas Urology - Green Valley, Henderson, Nevada, United States

Las Vegas Urology - Pebble, Henderson, Nevada, United States

Urology Specialists of Nevada - Green Valley, Henderson, Nevada, United States

Las Vegas Urology - Pecos, Las Vegas, Nevada, United States

Desert West Surgery, Las Vegas, Nevada, United States

OptumCare Cancer Care at Charleston, Las Vegas, Nevada, United States

University Medical Center of Southern Nevada, Las Vegas, Nevada, United States

Hope Cancer Care of Nevada, Las Vegas, Nevada, United States

Radiation Oncology Centers of Nevada Central, Las Vegas, Nevada, United States

Urology Specialists of Nevada - Central, Las Vegas, Nevada, United States

GenesisCare USA - Las Vegas, Las Vegas, Nevada, United States

Sunrise Hospital and Medical Center, Las Vegas, Nevada, United States

Las Vegas Prostate Cancer Center, Las Vegas, Nevada, United States

Las Vegas Urology - Sunset, Las Vegas, Nevada, United States

Urology Specialists of Nevada - Southwest, Las Vegas, Nevada, United States

Radiation Oncology Centers of Nevada Southeast, Las Vegas, Nevada, United States

Ann M Wierman MD LTD, Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas, Nevada, United States

GenesisCare USA - Vegas Tenaya, Las Vegas, Nevada, United States

Las Vegas Urology - Cathedral Rock, Las Vegas, Nevada, United States

Las Vegas Urology - Smoke Ranch, Las Vegas, Nevada, United States

OptumCare Cancer Care at MountainView, Las Vegas, Nevada, United States

Urology Specialists of Nevada - Northwest, Las Vegas, Nevada, United States

Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada - Town Center, Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas, Nevada, United States

Summerlin Hospital Medical Center, Las Vegas, Nevada, United States

Las Vegas Cancer Center-Medical Center, Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States

GenesisCare USA - Fort Apache, Las Vegas, Nevada, United States

OptumCare Cancer Care at Fort Apache, Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas, Nevada, United States

University Cancer Center, Las Vegas, Nevada, United States

Hope Cancer Care of Nevada-Pahrump, Pahrump, Nevada, United States

Renown Regional Medical Center, Reno, Nevada, United States

Saint Mary's Regional Medical Center, Reno, Nevada, United States

Radiation Oncology Associates, Reno, Nevada, United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire, United States

Roswell Park Cancer Institute, Buffalo, New York, United States

Southeastern Medical Oncology Center-Clinton, Clinton, North Carolina, United States

Southeastern Medical Oncology Center-Goldsboro, Goldsboro, North Carolina, United States

Southeastern Medical Oncology Center-Jacksonville, Jacksonville, North Carolina, United States

Vidant Oncology-Kenansville, Kenansville, North Carolina, United States

ECU Health Oncology Kinston, Kinston, North Carolina, United States

Vidant Oncology-Richlands, Richlands, North Carolina, United States

Sanford Bismarck Medical Center, Bismarck, North Dakota, United States

Sanford Broadway Medical Center, Fargo, North Dakota, United States

Sanford Roger Maris Cancer Center, Fargo, North Dakota, United States

Indu and Raj Soin Medical Center, Beavercreek, Ohio, United States

Strecker Cancer Center-Belpre, Belpre, Ohio, United States

Saint Elizabeth Boardman Hospital, Boardman, Ohio, United States

Dayton Physicians LLC-Miami Valley South, Centerville, Ohio, United States

Miami Valley Hospital South, Centerville, Ohio, United States

Adena Regional Medical Center, Chillicothe, Ohio, United States

Good Samaritan Hospital - Cincinnati, Cincinnati, Ohio, United States

Oncology Hematology Care Inc-Kenwood, Cincinnati, Ohio, United States

Bethesda North Hospital, Cincinnati, Ohio, United States

TriHealth Cancer Institute-Westside, Cincinnati, Ohio, United States

TriHealth Cancer Institute-Anderson, Cincinnati, Ohio, United States

Mount Carmel East Hospital, Columbus, Ohio, United States

Columbus Oncology and Hematology Associates Inc, Columbus, Ohio, United States

Riverside Methodist Hospital, Columbus, Ohio, United States

Grant Medical Center, Columbus, Ohio, United States

The Mark H Zangmeister Center, Columbus, Ohio, United States

Mount Carmel Health Center West, Columbus, Ohio, United States

Doctors Hospital, Columbus, Ohio, United States

Miami Valley Hospital, Dayton, Ohio, United States

Dayton Physician LLC - Englewood, Dayton, Ohio, United States

Miami Valley Hospital North, Dayton, Ohio, United States

Delaware Health Center-Grady Cancer Center, Delaware, Ohio, United States

Grady Memorial Hospital, Delaware, Ohio, United States

Dublin Methodist Hospital, Dublin, Ohio, United States

Armes Family Cancer Center, Findlay, Ohio, United States

Blanchard Valley Hospital, Findlay, Ohio, United States

Orion Cancer Care, Findlay, Ohio, United States

Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio, United States

Dayton Physicians LLC-Atrium, Franklin, Ohio, United States

Central Ohio Breast and Endocrine Surgery, Gahanna, Ohio, United States

Dayton Physicians LLC-Wayne, Greenville, Ohio, United States

Wayne Hospital, Greenville, Ohio, United States

Mount Carmel Grove City Hospital, Grove City, Ohio, United States

Greater Dayton Cancer Center, Kettering, Ohio, United States

Kettering Medical Center, Kettering, Ohio, United States

Fairfield Medical Center, Lancaster, Ohio, United States

Saint Rita's Medical Center, Lima, Ohio, United States

OhioHealth Mansfield Hospital, Mansfield, Ohio, United States

Marietta Memorial Hospital, Marietta, Ohio, United States

OhioHealth Marion General Hospital, Marion, Ohio, United States

Memorial Hospital, Marysville, Ohio, United States

Knox Community Hospital, Mount Vernon, Ohio, United States

Licking Memorial Hospital, Newark, Ohio, United States

Newark Radiation Oncology, Newark, Ohio, United States

Southern Ohio Medical Center, Portsmouth, Ohio, United States

Springfield Regional Cancer Center, Springfield, Ohio, United States

Springfield Regional Medical Center, Springfield, Ohio, United States

Mercy Health - Saint Vincent Hospital, Toledo, Ohio, United States

Mercy Health - Saint Anne Hospital, Toledo, Ohio, United States

Toledo Clinic Cancer Centers-Toledo, Toledo, Ohio, United States

Dayton Physicians LLC - Troy, Troy, Ohio, United States

Upper Valley Medical Center, Troy, Ohio, United States

Saint Joseph Warren Hospital, Warren, Ohio, United States

Saint Ann's Hospital, Westerville, Ohio, United States

Saint Elizabeth Youngstown Hospital, Youngstown, Ohio, United States

Genesis Healthcare System Cancer Care Center, Zanesville, Ohio, United States

Cancer Centers of Southwest Oklahoma Research, Lawton, Oklahoma, United States

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States

Integris Southwest Medical Center, Oklahoma City, Oklahoma, United States

Mercy Hospital Oklahoma City, Oklahoma City, Oklahoma, United States

Saint Alphonsus Medical Center-Baker City, Baker City, Oregon, United States

Saint Charles Health System, Bend, Oregon, United States

Clackamas Radiation Oncology Center, Clackamas, Oregon, United States

Providence Cancer Institute Clackamas Clinic, Clackamas, Oregon, United States

Bay Area Hospital, Coos Bay, Oregon, United States

Providence Newberg Medical Center, Newberg, Oregon, United States

Saint Alphonsus Medical Center-Ontario, Ontario, Oregon, United States

Providence Willamette Falls Medical Center, Oregon City, Oregon, United States

Providence Portland Medical Center, Portland, Oregon, United States

Providence Saint Vincent Medical Center, Portland, Oregon, United States

Saint Charles Health System-Redmond, Redmond, Oregon, United States

Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania, United States

Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania, United States

Geisinger Medical Center, Danville, Pennsylvania, United States

Pocono Medical Center, East Stroudsburg, Pennsylvania, United States

Saint Vincent Hospital, Erie, Pennsylvania, United States

Geisinger Medical Center-Cancer Center Hazleton, Hazleton, Pennsylvania, United States

Lehigh Valley Hospital-Hazleton, Hazleton, Pennsylvania, United States

Jefferson Hospital, Jefferson Hills, Pennsylvania, United States

Geisinger Medical Oncology-Lewisburg, Lewisburg, Pennsylvania, United States

Forbes Hospital, Monroeville, Pennsylvania, United States

University of Pennsylvania/Abramson Cancer Center, Philadelphia, Pennsylvania, United States

Allegheny General Hospital, Pittsburgh, Pennsylvania, United States

West Penn Hospital, Pittsburgh, Pennsylvania, United States

Geisinger Cancer Services-Pottsville, Pottsville, Pennsylvania, United States

Community Medical Center, Scranton, Pennsylvania, United States

Wexford Health and Wellness Pavilion, Wexford, Pennsylvania, United States

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre, Pennsylvania, United States

Avera Cancer Institute-Aberdeen, Aberdeen, South Dakota, United States

Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota, United States

Avera Cancer Institute, Sioux Falls, South Dakota, United States

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota, United States

Baptist Memorial Hospital and Cancer Center-Collierville, Collierville, Tennessee, United States

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis, Tennessee, United States

Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee, United States

Hendrick Medical Center, Abilene, Texas, United States

Saint Joseph Regional Cancer Center, Bryan, Texas, United States

Farmington Health Center, Farmington, Utah, United States

University of Utah Sugarhouse Health Center, Salt Lake City, Utah, United States

Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah, United States

Bon Secours Memorial Regional Medical Center, Mechanicsville, Virginia, United States

Bon Secours Westchester Emergency Center, Midlothian, Virginia, United States

Bon Secours Saint Francis Medical Center, Midlothian, Virginia, United States

Bon Secours Saint Mary's Hospital, Richmond, Virginia, United States

Providence Regional Cancer System-Aberdeen, Aberdeen, Washington, United States

Overlake Medical Center, Bellevue, Washington, United States

PeaceHealth Saint Joseph Medical Center, Bellingham, Washington, United States

Harrison HealthPartners Hematology and Oncology-Bremerton, Bremerton, Washington, United States

Highline Medical Center-Main Campus, Burien, Washington, United States

Providence Regional Cancer System-Centralia, Centralia, Washington, United States

Swedish Cancer Institute-Edmonds, Edmonds, Washington, United States

Saint Elizabeth Hospital, Enumclaw, Washington, United States

Providence Regional Cancer Partnership, Everett, Washington, United States

Saint Francis Hospital, Federal Way, Washington, United States

Swedish Cancer Institute-Issaquah, Issaquah, Washington, United States

Kadlec Clinic Hematology and Oncology, Kennewick, Washington, United States

Providence Regional Cancer System-Lacey, Lacey, Washington, United States

Saint Clare Hospital, Lakewood, Washington, United States

PeaceHealth Saint John Medical Center, Longview, Washington, United States

Jefferson Healthcare, Port Townsend, Washington, United States

Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo, Washington, United States

Valley Medical Center, Renton, Washington, United States

Pacific Gynecology Specialists, Seattle, Washington, United States

Swedish Medical Center-Ballard Campus, Seattle, Washington, United States

Swedish Medical Center-Cherry Hill, Seattle, Washington, United States

Swedish Medical Center-First Hill, Seattle, Washington, United States

PeaceHealth United General Medical Center, Sedro-Woolley, Washington, United States

Providence Regional Cancer System-Shelton, Shelton, Washington, United States

Saint Michael Cancer Center, Silverdale, Washington, United States

Franciscan Research Center-Northwest Medical Plaza, Tacoma, Washington, United States

Northwest Medical Specialties PLLC, Tacoma, Washington, United States

PeaceHealth Southwest Medical Center, Vancouver, Washington, United States

Providence Saint Mary Regional Cancer Center, Walla Walla, Washington, United States

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima, Washington, United States

Providence Regional Cancer System-Yelm, Yelm, Washington, United States

Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin, United States

Mayo Clinic Health System-Eau Claire Clinic, Eau Claire, Wisconsin, United States

Gundersen Lutheran Medical Center, La Crosse, Wisconsin, United States

Mayo Clinic Health System-Franciscan Healthcare, La Crosse, Wisconsin, United States

Marshfield Medical Center-Marshfield, Marshfield, Wisconsin, United States

Marshfield Clinic-Minocqua Center, Minocqua, Wisconsin, United States

ProHealth D N Greenwald Center, Mukwonago, Wisconsin, United States

Cancer Center of Western Wisconsin, New Richmond, Wisconsin, United States

ProHealth Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin, United States

Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin, United States

Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin, United States

ProHealth Waukesha Memorial Hospital, Waukesha, Wisconsin, United States

UW Cancer Center at ProHealth Care, Waukesha, Wisconsin, United States

Marshfield Medical Center - Weston, Weston, Wisconsin, United States

Cheyenne Regional Medical Center-West, Cheyenne, Wyoming, United States

Billings Clinic-Cody, Cody, Wyoming, United States

Welch Cancer Center, Sheridan, Wyoming, United States

Contact Details

Name: Vincent Chung

Affiliation: SWOG Cancer Research Network

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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