Spots Global Cancer Trial Database for Integrated Clinical-radiological Analysis of Hypoxia Markers in Pediatric Osteosarcomas
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Trial Identification
Brief Title: Integrated Clinical-radiological Analysis of Hypoxia Markers in Pediatric Osteosarcomas
Official Title: Integrated Clinical-radiological Analysis of Hypoxia Markers in Pediatric Osteosarcomas - Single-center Pilot Study of 32 Patients
Study ID: NCT05107843
Conditions
Interventions
Study Description
Brief Summary: The aim of this pilot study is therefore to retrospectively measure the volume and percentage of necrosis on diagnostic MRI in T1 sequence and in parallel to study the expression of immunohistochemical markers of hypoxia (HIF-1α, CAIX , HIF-2α, pS6, phosphomTor, CD163 and CD68) on diagnostic biopsies of high-grade osteosarcomas from 2007 to 2018 in the Strasbourg center, focusing on the pediatric population. The investigators will systematically carry out a correlation analysis between these different parameters and with the clinical data of these same patients (response to chemotherapy, presence of metastases or not and overall and recurrence-free survival). This will eventually make it possible to highlight new prognostic markers at diagnosis.
Detailed Description:
Eligibility
Minimum Age: 1 Year
Eligible Ages: CHILD, ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Service Pédiatrie Onco-hématologie - Pédiatrie III - Hôpitaux Universitaires de Strasbourg, Strasbourg, , France
Contact Details
Name: Natacha ENTZ-WERLE, MD, PhD
Affiliation: Service Pédiatrie Onco-hématologie - Pédiatrie III - Hôpitaux Universitaires de Strasbourg
Role: PRINCIPAL_INVESTIGATOR
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