Spots Global Cancer Trial Database for Expanded Access to Ulixertinib (BVD-523) in Patients With Advanced MAPK Pathway-Altered Malignancies
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Trial Identification
Brief Title: Expanded Access to Ulixertinib (BVD-523) in Patients With Advanced MAPK Pathway-Altered Malignancies
Official Title: Expanded Access to Ulixertinib (BVD-523) in Patients With Advanced MAPK Pathway-Altered Malignancies
Study ID: NCT04566393
Conditions
Interventions
Study Description
Brief Summary: The objective of this expanded access program is to provide ulixertinib (BVD-523) for compassionate use in advanced cancer patients with MAPK pathway-altered solid tumor(s), including but not limited to KRAS, NRAS, HRAS, BRAF, MEK, and ERK mutations who have incomplete response to or have exhausted available therapies. Ulixertinib is available for treatment as monotherapy or in combination with other clinically tolerable agent(s), conditionally approved by the drug manufacturer.
Detailed Description:
Keywords
Eligibility
Minimum Age: 12 Years
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Alabama at Birmingham, Birmingham, Alabama, United States
Clearview Cancer Institute, Huntsville, Alabama, United States
Infirmary Cancer Care, Mobile, Alabama, United States
PCR Oncology, Arroyo Grande, California, United States
Kaiser Permanente Los Angeles Medical Center, Los Angeles, California, United States
Hoag Memorial Hospital Presbyterian, Newport Beach, California, United States
xCures Inc., San Francisco, California, United States
Providence Saint John's Health Center, Santa Monica, California, United States
MedStar Georgetown University Hospital, Washington, District of Columbia, United States
Orlando Health, Orlando, Florida, United States
Iowa Oncology Research Association, Des Moines, Iowa, United States
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana, United States
Mount Desert Island Hospital, Bar Harbor, Maine, United States
Oakland Macomb Cancer Specialists, Sterling Heights, Michigan, United States
Cancer Partners of Nebraska, Lincoln, Nebraska, United States
Monmouth Medical Center, Long Branch, New Jersey, United States
The Minniti Center for Medical Oncology and Hematology, Mickleton, New Jersey, United States
Atlantic Health System/Overlook Medical Center, Summit, New Jersey, United States
Stony Brook Cancer Center, Stony Brook, New York, United States
The Christ Hospital, Cincinnati, Ohio, United States
The Toledo Clinic Cancer Center, Toledo, Ohio, United States
Lehigh Valley Health Network, Allentown, Pennsylvania, United States
Seattle Cancer Care Alliance, Seattle, Washington, United States
Contact Details
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