Spots Global Cancer Trial Database for Effects of Simvastatin on Biochemical Parameters and Outcome of IVF-ICSI in Pcos Patients
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Trial Identification
Brief Title: Effects of Simvastatin on Biochemical Parameters and Outcome of IVF-ICSI in Pcos Patients
Official Title: Effects of Simvastatin on Biochemical Parameters and Outcome of IVF-ICSI in Pcos Patients : A Prospective Randomized Double Blind Placebo Controlled Trial
Study ID: NCT00575601
Conditions
Interventions
Study Description
Brief Summary: The purpose of this study is to determine whether simvastatin is effective in the improvement of IVF-ICSI outcome in Pcos patients.
Detailed Description: simvastatin reduces cardiovascular risks by improving hypercholesterolemia, reducing vascular smooth muscle proliferation, ameliorating inflammation, limiting theca-interstitial proliferation \& decreasing steroidogenesis (production of progesterone \& testosterone).Polycystic ovary syndrome (pcos) is associated with increased cardiovascular risks and is characterized by ovarian theca-interstitial hyperplasia\& hyperandrogenism .This study will test the hypothesis that simvastatin improves biochemical parameters\& IVF-ICSI outcome in Pcos patients.
Keywords
Eligibility
Minimum Age: 20 Years
Eligible Ages: ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
Imam Khomeiny Hospital, Tehran, , Iran, Islamic Republic of
Contact Details
Name: batool hossein rashidi, MD
Affiliation: Tehran University of Medical Sciences
Role: STUDY_CHAIR
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