Symptoms and General Pathology

All Conditions

Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Gland and Hormone Related Diseases

Syndrome

Polycystic Ovary Syndrome

Cysts

Ovarian Cysts

Ovarian Diseases

Adnexal Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Gonadal Disorders

Endocrine System Diseases

Lipid Regulating Agents

All Drugs and Chemicals

Simvastatin

Anticholesteremic Agents

Hypolipidemic Agents

Antimetabolites

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Enzyme Inhibitors

20 mg/day,po,for two months until the day of hCG injection placebo pills as like as simvastatin will be used

SIMVASTATIN

batool hossein rashidi, MD

The purpose of this study is to determine whether simvastatin is effective in the improvement of IVF-ICSI outcome in Pcos patients.

simvastatin reduces cardiovascular risks by improving hypercholesterolemia, reducing vascular smooth muscle proliferation, ameliorating inflammation, limiting theca-interstitial proliferation \& decreasing steroidogenesis (production of progesterone \& testosterone).Polycystic ovary syndrome (pcos) is associated with increased cardiovascular risks and is characterized by ovarian theca-interstitial hyperplasia\& hyperandrogenism .This study will test the hypothesis that simvastatin improves biochemical parameters\& IVF-ICSI outcome in Pcos patients.

Effects of Simvastatin on Biochemical Parameters and Outcome of IVF-ICSI in Pcos Patients

Effects of Simvastatin on Biochemical Parameters and Outcome of IVF-ICSI in Pcos Patients : A Prospective Randomized Double Blind Placebo Controlled Trial

Tehran University of Medical Sciences

Akabr Fotouhi

Skin and Connective Tissue Diseases

Leiomyoma

Myofibroma

Myoma

Neoplasms, Connective and Soft Tissue

Neoplasms by Histologic Type

Neoplasms, Connective Tissue

Connective Tissue Diseases

Reproductive Control Agents

Chorionic Gonadotropin

women with intramural myoma not reaching endometrial cavity will undergo open myomectomy followed by ovarian stimulation for in vitro fertilization 6 months after the operation

women with intramural myoma not reaching endometrial cavity will undergo ovarian stimulation for in vitro fertilization

laparotomy then enucleation of the myoma followed by closure of the myometrial cavity

Open myomectomy

Gonadotropin stimulation of follicular growth

Gonadotropins

Human chorionic gonadotropin

Ovum pick up

Transfer of 2 grade 1 embryo on day 2,3 or 5 from oocyte retrieval

Embryo transfer

Ahmed Maged, MD

Women with intramural myoma not reaching the endometrial cavity will be randomized to either open myomectomy or no intervention . The participants will be assessed through full history-taking with special consideration to age and the duration, type, and cause of infertility. The medical examination included general, abdominal, and vaginal examinations. Finally, an ultrasonography examination was performed to check for the presence of three or more preantral follicles and to exclude ovarian cysts. On day 3 of a natural cycle, a baseline levels of FSH, luteinizing hormone (LH),

, estradiol and anti-Müllerian hormone (AMH).Ovarian stimulation was performed using a long, antagonist, or short protocol. They were assigned to one of the 2 groups according to having an intramural myoma not indenting the cavity or not. All will be followed up by transvaginal ultrasonography . When two or more follicles had reached a mean diameter of 18 mm, oocyte maturation was triggered by intramuscular administration of hCG. Embryo transfer will be done at day 2, 3 or 5 according to the circumstances.

Women with intramural myoma not reaching the endometrial cavity will be randomized to either open myomectomy or no intervention .The participants will be assessed through full history-taking with special consideration to age and the duration, type, and cause of infertility. The medical examination included general, abdominal, and vaginal examinations. Finally, an ultrasonography examination was performed to check for the presence of three or more preantral follicles and to exclude ovarian cysts. On day 3 of a natural cycle, a baseline levels of FSH, luteinizing hormone (LH),

, estradiol and anti-Müllerian hormone (AMH).Ovarian stimulation was performed using a long, antagonist, or short protocol. They were assigned to one of the 2 groups according to having an intramural myoma not indenting the cavity or not. All will be followed up by transvaginal ultrasonography . When two or more follicles had reached a mean diameter of 18 mm, oocyte maturation was triggered by intramuscular administration of hCG. Embryo transfer will be done at day 2, 3 or 5 according to the circumstances.

The Value of Myomectomy in Women With Intramural Myoma Before IVF.

The Value of Myomectomy in Women With Intramural Myoma Before IVF. A Randomized Controlled Trial

appearance of one or more intrauterine gestational sac by transvaginal ultrasound

Cairo University

Principal investigator

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Effects of Simvastatin on Biochemical Parameters and Outcome of IVF-ICSI in Pcos Patients	NCT00575601	Polycystic Ovar...	SIMVASTATIN	20 Years - 40 Years	Tehran University of Medical Sciences
Effects of Simvastatin on Biochemical Parameters and Outcome of IVF-ICSI in Pcos Patients	NCT00575601	Polycystic Ovar...	SIMVASTATIN	20 Years - 40 Years	Tehran University of Medical Sciences
The Value of Myomectomy in Women With Intramural Myoma Before IVF.	NCT03904368	Fibroid Uterus IVF	Open myomectomy Gonadotropins Human chorionic... Ovum pick up Embryo transfer	18 Years - 40 Years	Cairo University
Effects of Simvastatin on Biochemical Parameters and Outcome of IVF-ICSI in Pcos Patients	NCT00575601	Polycystic Ovar...	SIMVASTATIN	20 Years - 40 Years	Tehran University of Medical Sciences

Spots Global Cancer Trial Database for embryo transfer