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Spots Global Cancer Trial Database for Preoperative Combined RadioChemo-Molecular Target Therapy With Capecitabine, Bevacizumab, and Radiotherapy

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Preoperative Combined RadioChemo-Molecular Target Therapy With Capecitabine, Bevacizumab, and Radiotherapy

Official Title: Preoperative Combined RadioChemo-MolecularTargetTherapy of the Locally Advanced Rectum Carcinoma (cT3NxM0) - a Phase II Pilot Study With Preoperative Application of Capecitabine, Bevacizumab and Radiotherapy (RTx)

Study ID: NCT00671645

Conditions

Rectal Cancer

Study Description

Brief Summary: * feasibility and tolerance of preoperative therapy with Bevacizumab in combination with Capecitabine and radiotherapy for patients with locally advanced, locally operable rectal carcinoma * collection of response rate (T- and M-downstaging, pathological complete remission)

Detailed Description: Combined RadioChemotherapy: Therapy start: within 28 days after bioptical diagnosis Radiotherapy: 5 x 5 days 1.8 Gy radiotherapy; cummulative dose 45 Gy Chemotherapy: Capecitabin 825mg/m² bid, on each radiation day during the first 4 weeks RCTx Molecular Targeted Therapy: Bevacizumab 5 mg/kg body weight; day 1, 15, 29 Operation due to TME adherence to a break of min. 42 to max. 56 days after the last application of bevacizumab

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Hospital BHB St. Veit/Glan, Surgery, St. Veit/Glan, Carinthia, Austria

Medical University Graz, Oncology, Graz, Styria, Austria

State Hospital Leoben, Surgery, Leoben, Styria, Austria

Medical University Innsbruck, Internal Medicine, Innsbruck, Tyrol, Austria

Hospital BHS Linz, Radiooncology, Linz, Upper Austria, Austria

Klinikum Wels-Grieskirchen, Coop. Group, Wels, Upper Austria, Austria

State Hospital Feldkirch, Radiotherapy, Feldkirch, Vorarlberg, Austria

State Hospital Salzburg-Paracelsius Medical University - Oncology, Salzburg, , Austria

Hospital BHB Vienna, Surgery, Vienna, , Austria

Medical University Vienna, Radiotherapy, Vienna, , Austria

Contact Details

Name: Dietmar Oefner, MD, MSc

Affiliation: Austrian Breast & Colorectal Cancer Study Group

Role: PRINCIPAL_INVESTIGATOR

Name: Alexander de Vries, MD

Affiliation: Austrian Breast & Colorectal Cancer Study Group

Role: PRINCIPAL_INVESTIGATOR

Name: Wolfgang Eisterer, MD

Affiliation: ABCSG, TAKO

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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