Spots Global Cancer Trial Database for Proton Beam Radiation Therapy After Treatment for Resected N2 Non-Small Cell Lung Cancer

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Proton Beam Radiation Therapy After Treatment for Resected N2 Non-Small Cell Lung Cancer

Official Title: Proton Beam Radiation Therapy in Patients With Resected N2 Non-Small Cell Lung Cancer

Study ID: NCT06008730

Conditions

Resectable Lung Non-Small Cell Carcinoma

Interventions

Biospecimen Collection

Proton Beam Radiation Therapy

Radiology, Treatment Planning

Study Description

Brief Summary: This clinical trial tests proton beam radiation therapy in patients with non-small cell lung cancer who have undergone surgical resection and have lymph nodes involving the middle of the chest. Proton therapy is a type of radiation treatment that kills cancer cells while avoiding surrounding healthy tissue. Proton beam therapy is sometimes used after cancer surgery to reduce the risk of cancer recurrence (coming back). Giving proton beam radiation therapy may work better than conventional radiation treatment after surgery in patients with non-small cell lung cancer.

Detailed Description: PRIMARY OBJECTIVE: I. To assess the safety of proton beam radiation therapy (PBRT) for resected N2 non-small cell lung cancer (NSCLC). SECONDARY OBJECTIVES: I. To measure the radiation dose to the circulating immune compartment and explore its association with clinical endpoints. II. To assess the efficacy of PBRT for resected N2 NSCLC. OUTLINE: Patients undergo radiation treatment planning and then undergo proton beam radiation therapy on study. Patients also undergo collection of blood samples. Patients are followed up for 24 months after first dose of radiotherapy.