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Brief Title: Identify microRNAs in Cachexia in Pancreatic Carcinoma
Official Title: Pilot Trial to Identify microRNAs in Cachexia in Patients With Pancreatic Carcinoma
Study ID: NCT05275075
Brief Summary: The purpose of this study is to determine the proportion of pancreatic patients who experience weight loss and cachexia, and to identify any differences in the genes between patient groups.
Detailed Description: This research study will retrospectively examine 1395 patients from the University of Alabama and the University of Oklahoma Stephenson Cancer Center (OU-SCC) pancreatic cancer cohorts. The prospective arm, will enroll a total of 100 eligible volunteers at the OU-SCC. The demographic and medical data from the retrospective and prospective arms will be combined (1495 patients) to ascertain any racial disparities in pancreatic cancer patients with cachexia. Perspective volunteers at the OU-SCC will undergo routine tests to determine if their cancer is operable. Pancreatic tumors will be removed from the eligible patients, as part of their normal standard of care and will be examined for genes that may be related to unexplained muscle loss and compared to tumor tissue from other patients with pancreatic cancer. An optional hand strength exam, and standing on a scale that measures weight, muscle, and body fat will be available to OU-SCC patients.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Stephenson Cancer Center, Oklahoma City, Oklahoma, United States
Name: Ajay Jain, MD
Affiliation: University of Oklahoma Stephenson Cancer Center
Role: PRINCIPAL_INVESTIGATOR