Neoplasms

Digestive System Diseases

All Conditions

Symptoms and General Pathology

Rare Diseases

Esophageal Neoplasms

Body Weight

Gastrointestinal Neoplasms

Digestive System Neoplasms

Head and Neck Neoplasms

Gastrointestinal Diseases

Esophageal Diseases

Esophageal Cancer

As for patients in oral natural diet group, the the participants shall receive oral natural diet.

As for patients in oral nutrition supplement group, in addition to oral natural die, the participants shall receive oral enteral supplement providing 750-1500kcal/d.

As for patients in tube feeding group, in addition to oral natural die, the participants shall receive tube feeding nutrition supplement providing 750-1500kcal/d.

Oral nutrition supplement

As for patients in tube feeding group, in addition to oral natural die, the participants shall receive Tube feeding nutrition supplement providing 750-1500kcal/d.

Tube feeding nutrition supplement

Keneng Chen, M.D.

Liang Dai, M.D.

Yang Geng, Master

Zaicheng Yu, Master

Renquan Zhang, Master

Deruo Liu, M.D.

Zhipeng Ren, M.D.

Wei Guo, M.D.

Chun Chen, M.D.

Wenfeng Ye, M.D.

Guibin Qiao, M.D.

Ming He, M.D.

Jianqun Ma, M.D.

Xiaotian Shi, M.D.

Xiangning Fu, M.D.

Wenliang Liu, M.D.

Youbin Cui, M.D.

Hongxu Liu, M.D.

Hui Tian, M.D.

Zhou Wang, M.D.

Hong Hu, Master

Zhigang Li, M.D.

Shiping Guo, Master

Liang Bu, M.D.

Qixun Chen, M.D>

This clinical trial is designed to be a multi-center prospective observational study which shall compare the effect of different postoperative home nutrition modes on recent nutritional index (weight/BMI) of patients with esophageal cancer and recent outcomes. Different postoperative home nutrition modes adopted in this study includes oral natural diet, oral nutrition supplement and tube feeding.

STUDY BACKGROUND Esophageal cancer is a common cancer in China and due to its influence on diet intake, patients with esophageal cancer are often combined with nutrition deficiency, which causes relatively high nutrition risk to treatment. Studies conducted by Martin et al showed that the degree of body weight loss in patients with malignancy is related to BMI level and prognosis. The patients with severe body weight loss and low BMI have poor prognosis, especially for patients with esophageal cancer.

At present, perioperative nutrition support for patients with esophageal cancer has been recognized and has been recommended as routine in 2017 NCCN guideline. How to implement good home nutrition within one month after patient discharge and recover nutrition index as soon as possible has become a focus for esophageal surgeon.

Many clinical trials have already investigated enteral nutrition support approach during anti-cancer treatment period in patients with malignancy. However, only a few clinical trials are good designed. Therefore the investigators hope to via this multi-center prospective observational study to provide evidence for this question.

OBJECTIVES:

1. To explore the relationship between postoperative home nutrition support treatment approach and nutritional status of patients with esophageal cancer;
2. To explore the relationship between postoperative home nutrition support treatment approach and recent prognosis in patients with esophageal cancer;
3. To promote the standardized application of postoperative home nutrition support treatment for patients with esophageal cancer.\\

OUTLINE:

Included patients shall be divided into three groups according to the treatment plan of all centers, including oral natural diet, oral nutrition supplement and tube feeding. As for patients in oral natural diet group, the patients shall receive oral natural diet. As for patients in oral nutrition supplement group, in addition to oral natural die, the participants shall receive oral enteral supplement providing 750-1500kcal/d. As for patients in tube feeding group, in addition to oral natural die, the participants shall receive tube feeding enteral supplement providing 750-1500kcal/d.

All the included patients shall be followed up weekly within 1-3 weeks after discharge via telephone, at Day 30 after discharge and at Day 90 after discharge to assess the effectiveness and safety of different home nutrition supplement approaches.

PROJECTED ACCRUAL: A total of 600 patients will be accrued for this study.

Effect of Postoperative Family Nutrition Mode on Weight/BMI of Patients With Esophageal Cancer

Percentage of 5% body weight loss on Day 30 compared to the body weight at discharge

Completion ratio of different nutrition support approaches

Assessment on patients' quality of life using EORTC QLQ-C30 scale and QLQ-OG25 scale in different nutrition support approach groups and investigate the relationship between different nutrition support approaches and patients' quality of life

Assessment on complications of home enteral nutrition support

Delay and interruption ratio of adjuvant treatment including whether chemotherapy and radiotherapy can be implemented on time

Re-hospitalization ratio within 90 days after discharge

Sun Yat-sen University

Zhejiang Cancer Hospital

Shanghai Chest Hospital

China-Japan Friendship Hospital

Fudan University

Shandong Provincial Hospital

Hebei Medical University Fourth Hospital

Anyang Tumor Hospital

The First Affiliated Hospital of Anhui Medical University

First Affiliated Hospital Bengbu Medical College

Tongji Hospital

Shanxi Province Cancer Hospital

The Third Affiliated Hospital of Harbin Medical University

Liaoning Tumor Hospital & Institute

Wuhan General Hospital of Guangzhou Military Command

Second Xiangya Hospital of Central South University

The First Hospital of Jilin University

Chinese PLA General Hospital

Hunan Provincial People's Hospital

Fujian Cancer Hospital

Qilu Hospital of Shandong University

Union hospital of Fujian Medical University

Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

Peking University Cancer Hospital & Institute

Doctor

Spots Global Cancer Trial Database for tube feeding nutrition supplement