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D2 radical gastrectomy with partial omentectomy

D2 radical gastrectomy with total omentectom

Partial omentectomy with preservation of the greater omentum at \>3 cm from the gastroepiploic arcade.Control group with total omentectomy.

Type of omentectomy

Han Liang, Master

Bin Ke, Doctor

The main purpose of this study is to evaluate the impact of omentectomy for advanced gastric cancer on patient survival.

Surgical resection is the mainstay of treatment for gastric cancer. The extent of surgical resection includes total or subtotal gastrectomy, D2 lymphadenectomy, and prophylactic or therapeutic resection of the surrounding organs or tissues (e.g., omentum, peritoneum, etc). However, the oncologic importance of omentectomy during gastrectomy remains unclear. The European guidelines do not give any advice regarding omentectomy, whereas the most recent American guidelines advise to resect both the greater and lesser omentum. Alternatively, the Japanese gastric cancer treatment guidelines recommends preservation of the greater omentum at \>3 cm from the gastroepiploic arcade for patients with T1-T2 tumors and total omentectomy for patients with T3-T4 tumors. In order to evaluate the impact of omentectomy for advanced gastric cancer on patient survival, we designed this trial. Patients who received curative gastrectomy were divided into two groups based on whether they underwent omentectomy. The primary endpoint is the 3-year relapse-free survival rate and the secondary endpoints are 5-year overall survival, and postoperative morbidity.

A Trial of Total Versus Partial Omentectomy for Advanced Gastric Cancer in Gastrectomy

A Single-center, Randomized, Controlled Trial to Evaluate Total Versus Partial Omentectomy for Advanced Gastric Cancer in Radical Gastrectomy

The volume of intraoperative blood loss (IBL) was defined as the total from suction and the weight of gauze sponges at the conclusion of the operation. The Blood loss volume is recorded in milliliters.

The length of the operation was defined as the time from first skin incision to wound closure. The length of the operation is recorded in minutes.

Postoperative hospital stay was defined as the time from the date of operation to the date of discharge. The postoperative hospital stay is recorded in days.

Postoperative morbidity was defined as the incidence rate of the postoperative complication. The postoperative morbidity were examined within 30 days after surgery. Postoperative morbidity was graded with use of the modified Clavien-Dindo classification of surgical complications.

Relapse-free survival l (RFS) was defined as the length of time from the date of randomization to the date of first documentation of relapse of gastric cancer or any other type of cancer or death.

Overall survival (OS) was defined as the length of time from the date of randomization to the date of death of various reasons.

Tianjin Medical University Cancer Institute and Hospital

Partial omentectomy with preservation of the greater omentum at \>3 cm from the gastroepiploic arcade.

Experimental group D2 radical gastrectomy with partial omentectomy. Partial omentectomy with preservation of the greater omentum at \>3 cm from the gastroepiploic arcade.Control group with total omentectomy.

Bik Ke, Doctor

Liang Han

This is a phase III, multicenter, prospective, randomized, controlled clinical trial to evaluate the impact of omentectomy for advanced gastric cancer on patient survival.

In order to evaluate the impact of omentectomy for advanced gastric cancer on patient survival, we designed this trial. Patients who received curative gastrectomy were divided into two groups based on whether they underwent omentectomy. The purpose of this study is to prove the non-inferiority of omentum preservation compared with omentectomy in patients with T3-T4a gastric cancer.

A Phase III Study Comparing Total and Partial Omentectomy for Patients With Advanced Gastric Cancer

A Phase III, Multicenter, Prospective, Randomized, Controlled Clinical Trial Comparing Total and Partial Omentectomy for Patients With Advanced Gastric Cancer (TOP-GC)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
A Trial of Total Versus Partial Omentectomy for Advanced Gastric Cancer in Gastrectomy	NCT04108494	Gastric Cancer	Type of omentec...	18 Years - 70 Years	Tianjin Medical University Cancer Institute and Hospital
A Phase III Study Comparing Total and Partial Omentectomy for Patients With Advanced Gastric Cancer	NCT04843215	Gastric Cancer	Type of omentec...	18 Years - 70 Years	Tianjin Medical University Cancer Institute and Hospital

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