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Udenafil

Phosphodiesterase 5 Inhibitors

Phosphodiesterase Inhibitors

Enzyme Inhibitors

Cola

oral administration of placebo for Udenafil (Dong-A Pharmaceutical co., Ltd, Seoul, Korea)

oral administration of Udenafil, prn(2hours before anticipated intercourse, 8 times/months)

Sung-Bum Kang, M.D., Ph.D

The purpose of this study is to evaluate the efficacy of Udenafil (Zydena®, Dong-A Pharmaceutical co., Ltd, Seoul, Korea) in treatment of erectile dysfunction after radical resection for sigmoid colon and rectal cancer. In this study, the efficacy of Udenafil will be evaluated in treatment for patient with chronic erectile dysfunction, which developed after radical resection for sigmoid and rectal cancer and continues 12 months after the surgery.

Post-pelvic surgery erectile dysfunction is of much interest to those performing sigmoid colon and rectal cancer surgery and their patients. Erectile dysfunction has been recognized to develop from damage to pelvic parasympathetic nerve, which are especially vulnerable during anterior rectal dissection. There may be also a contribution of psychological factors from the presence of stoma and fear of recurrent cancer. Recently, several studies reported that erectile dysfunction after rectal excision for rectal cancer was completely reversed or satisfactorily improved using oral erectile dysfunction drugs. Udenafil is a new phosphodiesterase type 5 (PDE 5) inhibitor for erectile dysfunction. Prior studies have also demonstrated a selectivity profile for udenafil that is similar to Sildenafil (viagra®) and tadalafil (Cialis®). But unlike tadalafil (Cialis®), it does not significantly inhibit the PDE11 isozyme and not produce significant myalgia. back pain, or leg pain.

This prospective, randomized study was designed to evaluate the efficacy of Udenafil treatment in treatment of erectile dysfunction after radical resection for sigmoid colon and rectal cancer. In order to conduct this study, enrolled patients will be randomly attributed to Udenafil group or placebo group.

Efficacy of Udenafil After Radical Resection for Sigmoid Colon and Rectal Cancer

Efficacy of Udenafil in Treatment of Erectile Dysfunction After Radical Resection for Sigmoid Colon and Rectal Cancer : a Randomized Controlled Trial

Seoul National University Hospital

Professor

Individuals who take placebo after total mesorectal excision

Individuals who take udenafil after total mesorectal excision

After total mesorectal excision for rectal cancer, patients take placebo drug five time per week for 12 weeks.

Placebo drug

After total mesorectal excision, patients take 50mg udenafil five times per week for 12 weeks.

Sexual dysfunctions are well-recognized complications after rectal cancer surgery. Damage to the pelvic plexus and pelvic splanchnic nerves results in ejaculatory dysfunction. The purpose of this study is to evaluate the efficacy of Udenafil(Zydena®, Dong-A Pharmaceutical co., Ltd, Seoul, Korea) in penile rehabilitation for patients who undertake total mesorectal excision.

The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer

* IIEF-5 questionnaire is used to assess male erectile function
* IIEF-5 (5-item Version of the International Index of Erectile Function)is obtained by combining the scores of the responses to 5 questions. Each question is scored from 0-5 (1 questions is scored from 1-5) for IIEF-5 range of 1-25 points; lower numerical scores from the IIEF-5 questionnaire represnt greater severitt of erectile dysfunction.

* SEP Q2 (Sexual encounter profile Q2) and SEP Q3 (Sexual encounter profile Q3) are used to assess erectile function
* The efficaty of medication is followed by GEQ (Global efficacy question).

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Efficacy of Udenafil After Radical Resection for Sigmoid Colon and Rectal Cancer	NCT00607282	Erectile Dysfun... Sigmoid Colon C... Rectal Cancer	Udenafil	19 Years - 70 Years	Seoul National University Hospital
The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer	NCT01421940	Rectal Cancer	Placebo drug Udenafil	20 Years - 65 Years	Kyungpook National University Hospital
The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer	NCT01421940	Rectal Cancer	Placebo drug Udenafil	20 Years - 65 Years	Kyungpook National University Hospital
The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer	NCT01421940	Rectal Cancer	Placebo drug Udenafil	20 Years - 65 Years	Kyungpook National University Hospital

Spots Global Cancer Trial Database for udenafil

Every month we try and update this database with for udenafil cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for udenafil

Every month we try and update this database with for udenafil cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for udenafil cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.