Neoplasms

Gland and Hormone Related Diseases

All Conditions

Symptoms and General Pathology

Respiratory Tract (Lung and Bronchial) Diseases

Ear, Nose, and Throat Diseases

Nervous System Diseases

Thyroid Neoplasms

Thyroid Diseases

Thyroid Nodule

Tissue Adhesions

Voice Disorders

Endocrine System Diseases

Endocrine Gland Neoplasms

Head and Neck Neoplasms

Laryngeal Diseases

Respiratory Tract Diseases

Otorhinolaryngologic Diseases

Neurologic Manifestations

Use of Anti-adhesion barrier on the thyroidectomy space. After the thyroidectomy, anti-adhesion barrier will be applied on the thyroidectomy space, around the trachea, cricothyroid muscle and platysma muscle before the closure of surgical wound.

No use of anti-adhesion barrier. After the thyroidectomy, don't use the anti-adhesion barrier before the wound closure.

Anti-adhesion barrier (Collarbarrier)

Jin Wook Yi, Professor

Jin Wook Yi, Dr.

To determine whether the use of anti-adhesion barrier after thyroid surgery can prevent the voice changes after surgery, using objective voice-related indicators.

* Randomized controlled study
* Including 40 patients in each arm
* Treatment: anti-adhesion barrier apply on the thyroidectomy space
* Control: No use of anti-adhesion barrier
* Primary outcome: VHI-30 (Voice handicap index)
* Secondary outcome: findings from stroboscopy, CSL (Computerize Speech Lab)
* Outcome measurement: preoperative, post-operative 3 months, post-operative 9 months.

Treatment: Use of Anti-adhesion barrier on the thyroidectomy space Control: No use of anti-adhesion barrier

Participants do not know about the use of anti-adhesion agents.

Effect of Anti-adhesion Barrier on the Voice Quality After Thyroidectomy.

A Prospective Randomized Controlled Study of Whether Anti-adhesion Barrier Can Prevent Voice Quality After Thyroidectomy.

In order to protect the privacy of patients, the original data of the study will not be disclosed.

Grade, Rough, Breathy, Asthenic, Strained score. (0-3 points in each parameter)

Inha University Hospital

Assistant Professor

Rare Diseases

Carcinoma

Carcinoma, Squamous Cell

Squamous Cell Carcinoma of Head and Neck

Laryngeal Neoplasms

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Otorhinolaryngologic Neoplasms

Respiratory Tract Neoplasms

Laryngeal Cancer

All Drugs and Chemicals

Hyaluronic Acid

Adjuvants, Immunologic

Immunologic Factors

Viscosupplements

Protective Agents

Randomized group of patients receiving hyaluronic acid injection into the glottis during transoral laser microsurgery for early glottic cancer.

Randomized group of patients not receiving hyaluronic acid injection into the glottis during transoral laser microsurgery for early glottic cancer.

Patients in the treatment group received hyaluronic acid injection into the unaffected vocal cord intra-operatively during transoral laser microsurgery for early glottic cancer.

Hyaluronic acid

Patients in the placebo group did not receive hyaluronic acid injection into the unaffected vocal cord intra-operatively during transoral laser microsurgery for early glottic cancer.

No Hyaluronic Acid Injection Injection

Objectives: Transoral Laser Microsurgery (TLM) is widely used in for treating T1/T2 glottic cancers. Hyaluronic acid (HA) is a safe and commonly-used injectable in vocal cord augmentation. We report on the results of our single-blinded, randomized-controlled trial (RCT) investigating the impact of intra-operative HA injection on voice outcomes in early glottic cancer.

Methods: Patients with T1/T2 glottic cancers were randomized to the treatment group (n=14) receiving HA injection to the unaffected cord during TLM; or the control group, receiving no injection (n=16). All patients had a Voice Handicap Index-10 (VHI-10) questionnaire and a Maximum Phonation Time (MPT) measurement preoperatively and at 3, 12 and 24 months post-operatively. Mean change in VHI-10 and MPT, between pre-operative and post-operative time points, and between the time points, were compared. Survival estimates were also calculated.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Effect of Anti-adhesion Barrier on the Voice Quality After Thyroidectomy.	NCT04853680	Thyroid Nodule Thyroid Cancer Voice Disorders	Anti-adhesion b...	20 Years - 70 Years	Inha University Hospital
Phonosurgical Augmentation After Laser Resection of Early Glottic Carcinoma	NCT04525066	Head and Neck N... Head and Neck S... Voice Disorders Laryngeal Cance...	Hyaluronic acid No Hyaluronic A...	18 Years - 100 Years	Nova Scotia Health Authority
Effect of Anti-adhesion Barrier on the Voice Quality After Thyroidectomy.	NCT04853680	Thyroid Nodule Thyroid Cancer Voice Disorders	Anti-adhesion b...	20 Years - 70 Years	Inha University Hospital

Spots Global Cancer Trial Database for voice disorders