Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Breast Neoplasms

Prostatic Neoplasms

Genital Neoplasms, Male

Urogenital Neoplasms

Genital Diseases

Genital Diseases, Male

Urogenital Diseases

Prostatic Diseases

Male Urogenital Diseases

745 patients with HER2-positive and triple-negative breast cancer who underwent neoadjuvant therapy followed by breast surgery.

137 patients with metastatic prostate cancer

Somatic and germline whole exome sequencing will be analyzed for prostate and HER2-positive breast cancer

Somatic whole exome and germline whole genome sequencing will be analyzed for triple-negative breast cancer

whole exome and whole genome sequencing analysis

Marina Bessel

André Mancini

Eduardo K Neto

Gláucio A Bertollo

Daniela L Louzeiro

Flávio Brandão

Angélica N Rodrigues

Aline BL Gongora

Williams F Barra

Edilmar M Santos

Alessandra Notari

Cristiano P Souza

Henrique G Ascenço

Ruffo Freitas Jr.

Pedro ER Liedke

Gustavo Werutsky

Juliana J Menezes

Christina PO Kussler

Lilian AR Barros

Vitor F Vasconcellos

Daniela D Rosa, PhD

This project aims to perform complete sequencing of the somatic (tumor) and germline exomes during clinical investigation of cancer patients treated through the Brazilian Unified Health System to generate genomic and phenotypic data for the Brazilian Ministry of Health's National Precision Genomics and Health Program, called Genomas Brasil, as well as to collect data on the population's ancestry.

In Brazil, the most frequent types of neoplasm are prostate cancer in men and breast cancer in women. Understanding the molecular variants in tumors, which result from mutations and variants that occur during carcinogenesis, can affect treatment response and disease prognosis and is an important target of oncology research. Detecting hereditary genetic syndromes also helps in oncological follow-up, allowing prediction of the risk of new neoplasms. This project aims to perform complete sequencing of the somatic (tumor) and germline exomes during clinical investigation of cancer patients treated through the Brazilian Unified Health System to generate genomic and phenotypic data for the Brazilian Ministry of Health's National Precision Genomics and Health Program, called Genomas Brasil, as well as to collect data on the population's ancestry.

Whole blood and formalin-fixed paraffin-embedded (FFPE) tissue

Onco-Genomas Brasil: Mapping Breast and Prostate Cancer in the Brazilian Public Health System

Characterize the genomic ancestry of Brazilian patients with breast and prostate cancer

Mutations in the somatic and germline exomes/genomes of women with HER2-positive and triple-negative breast cancer and of men with metastatic prostate cancer will be described

Mutations in the somatic and germline exomes/genomes will be correlated to clinical outcomes

Mutations in the somatic and germline exomes/genomes will be correlated to response to treatments

Identify mutations in germline exomes/genomes related to hereditary cancer syndromes

Spots Global Cancer Trial Database for whole exome and whole genome sequencing analysis