This intervention will use the NCCN Distress Screening Thermometer to score each participant on their level of distress. Depending on the score the intervention will be tailored to the participant based on the Overview of Evaluation and Treatment Schema DIS-4 per the NCCN Distress Guidelines V1.0, 2016.

Screening took with an overall distress ranging from 0-10 and additional stress items in the areas of practical problems, family problems, emotional problems, spiritual or religious concerns, and physical problems

Distress Screening Thermometer

Based on the NCCN Guidelines Version 1.0.2016 which recommend brief screening, evaluation, and treatment of distress

NCCN Guidelines: Distress management

Amelia Baffa, RN, MSN

The purpose of this study is to help adolescents and young adult cancer survivors address their psycho-social needs during the transitional period. The transitional period begins at completion of cancer treatment and continues throughout that first year. Patients often report this period can be difficult and distressing in many areas of life. This study will use a simple tool to measure, on a regular basis, the level of distress a young adult may be feeling. Based on this assessment additional mental health support and intervention can be recommended to help cancer survivors cope and enhance their feelings of well-being.

Study Objective:

To establish a successful distress based intervention program for adolescent and young adult survivors in the transition period.

Study Design and Methods:

The type of design for this study is a feasibility pilot study with repeated measure, within group quantitative design. There is no randomization for this study. The patient will be assessed; at baseline, upon completion of therapy, and at regular three month intervals for the first year, for a total of five assessments. After receiving a referral a member of the AYAST team will contact the patient and set up the initial visit.

Adolescent and Young Adult Survivor Transition

Adolescent and Young Adult Survivor Transition (AYAST)

The study coordinators are using the NCCN Distress Screening Thermometer (DST) to screen patients. This includes a using the combined score of the NCCN DST and the associated problem list containing 39 items

The NCCN Distress Thermometer consists a single-item self- report measure of psychological distress, which consists of an 11-point scale with the endpoints labeled "No distress" (0) and "Extreme distress" (10)

Case Comprehensive Cancer Center

Neoplasms

Blood and Lymph Conditions

All Conditions

Skin and Connective Tissue Diseases

Digestive System Diseases

Gland and Hormone Related Diseases

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Nervous System Diseases

Respiratory Tract (Lung and Bronchial) Diseases

Immune System Diseases

Heart and Blood Diseases

Musculoskeletal Diseases

Rare Diseases

Leukemia

Breast Neoplasms

Pancreatic Neoplasms

Skin Neoplasms

Prostatic Neoplasms

Thyroid Neoplasms

Thyroid Diseases

Glioblastoma

Brain Neoplasms

Osteosarcoma

Head and Neck Neoplasms

Sarcoma

Lung Neoplasms

Lymphoma

Multiple Myeloma

Neoplasms, Plasma Cell

Lymphoma, Non-Hodgkin

Hodgkin Disease

Bone Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Neoplasms by Histologic Type

Lymphoproliferative Disorders

Lymphatic Diseases

Immunoproliferative Disorders

Gastrointestinal Diseases

Hemostatic Disorders

Blood Coagulation Disorders

Vascular Diseases

Paraproteinemias

Blood Protein Disorders

Hematologic Diseases

Hemorrhagic Disorders

Astrocytoma

Glioma

Neoplasms, Neuroepithelial

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms, Glandular and Epithelial

Neoplasms, Nerve Tissue

Endocrine Gland Neoplasms

Endocrine System Diseases

Pancreatic Diseases

Central Nervous System Neoplasms

Nervous System Neoplasms

Brain Diseases

Central Nervous System Diseases

Bone Diseases

Pancreatic Cancer

Soft Tissue Sarcoma

Lymphosarcoma

Hodgkin Lymphoma

Neuroepithelioma

Participants will be asked to complete a 12 week virtual physical activity program delivered by the BurnAlong app, participate in a discussion board, and engage in live physical activity sessions with an exercise physiologist.

Participants will engage in two to three virtual physical activity sessions a week through the BurnAlong app for three months with a chosen partner and participate at least twice a week in the research team-mediated social media message board. Additionally, participants will be asked to participate in one live physical activity session per month with an exercise physiologist.

Virtual group based physical activity (BurnAlong) and Social Media Discussion Board

Susan Whiteway, LtCol USAF, MD

Celina H Shirazipour, Ph.D.

The purpose of this prospective, interventional, single-arm pilot study is to evaluate whether virtually delivered group-based physical activity is feasible for adolescent and young adult (AYA) cancer survivors. AYAs who were diagnosed with cancer and have completed cancer treatment will be recruited for this study. This study will enroll 20 participants in total and will last approximately 3 months.

This is a single-arm, prospective, interventional pilot study.

Adolescent and young adult (AYA) survivors of cancer ages 18-39 (n=20) will engage in three months of virtually group physical activity (PA) delivered via BurnAlong, a wellness platform and online app.

Participants will be asked to engage in a BurnAlong workout session with a partner (friend/spouse/child/fellow study participant) a minimum of three times a week for 3 months.

Participants will also meet monthly with an exercise physiologist for a customized exercise session. Participants are allowed to engage in additional PA and non-PA sessions on BurnAlong as desired.

Participants will also be asked to engage in a private social network discussions around key topics of interest for AYA communities with a focus on post-traumatic growth and positive psychology with a minimum of 2 post engagements a week for 3 months.

Participants will complete surveys and physical assessments at baseline and at end of study.

Participants also participate in a 1 hr qualitative exit interview about their well-being, participation experiences, and experience with using the BurnAlong platform.

The BurnAlong Pilot Study for Adolescent and Young Adult Cancer Survivors

The BurnAlong Pilot Study: Examining the Feasibility of a Virtual Group-based Physical Activity Intervention for Adolescent and Young Adult Cancer Survivors

Number of participants that adhere to a 3-month virtually delivered physical activity program via BurnAlong, group discussion boards, and a monthly live physical activity session with an exercise physiologist

Evaluate impact of intervention on resting heart rate (bpm) at 3-months (compared to baseline day 0)

Evaluate impact of intervention on sleep duration (number of hours slept each night) at 3-months (compared to baseline day 0)

Evaluate impact of intervention on the percentage of time awake during the night at 3-months (compared to baseline day 0)

Evaluate short-term effects of virtually delivered exercise, partner support, and group discussion on well-being. PROMIS measures are scored on a T-score metric with a mean of 50 and standard deviation of 10. Scores can be categorized as: within normal limits, mild, moderate and severe.

Evaluate short-term effects of virtually delivered exercise, partner support, and group discussion on post-traumatic growth and self-improvement

Evaluate short-term effects of virtually delivered exercise, partner support, and group discussion on theoretical determinants of physical activity participation as proposed by the Health Action Process Approach (task self-efficacy, outcome expectancies, risk perception, intentions, planning, maintenance self-efficacy, recovery self-efficacy, physical activity behavior) by comparing data at baseline (day 0) and 3 months

Evaluate short-term effects of virtually delivered exercise, partner support, and group discussion on social well-being. PROMIS measures of the ability to participate in social roles and activities are scored on a T-score metric with a mean of 50 and standard deviation of 10. Scores can be categorized as: within normal limits, mild, moderate and severe.

Evaluate short-term effects of virtually delivered exercise, partner support, and group discussion on distress and areas of concern such as practical, family, emotional, social, physical, and information

12 item questionnaire that assesses the 6 experiential aspects of participation (autonomy, belongingness, challenge, engagement, mastery, and meaning) on a 7 point scale (1, strongly disagree, to 7, strongly agree)

Walter Reed National Military Medical Center

Cedars-Sinai Medical Center

Assistant Professor, Cancer Research Center for Health Equity, SOCCI

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Adolescent and Young Adult Survivor Transition	NCT02948712	Adolescent and ...	Distress Screen... NCCN Guidelines...	18 Years - 30 Years	Case Comprehensive Cancer Center
The BurnAlong Pilot Study for Adolescent and Young Adult Cancer Survivors	NCT05131815	Cancer Cancer Metastat... Neoplasms Breast Cancer Lung Cancer Thyroid Cancer Lymphoma Lymphoma, Non-H... Hodgkin Lymphom... Leukemia Sarcoma Skin Cancer Bone Cancer Gynecologic Can... Pancreas Cancer Multiple Myelom... Colorectal Canc... Gastrointestina... Prostate Cancer Glioblastoma Brain Cancer Head and Neck C...	Virtual group b...	18 Years - 39 Years	Cedars-Sinai Medical Center

Spots Global Cancer Trial Database for adolescent and young adult cancer