Heart and Blood Diseases

All Conditions

Neoplasms

Mouth and Tooth Diseases

Rare Diseases

Hypotension

Head and Neck Neoplasms

Mouth Neoplasms

Vascular Diseases

Mouth Diseases

Stomatognathic Diseases

Oral Cancer

Lip and Oral Cavity Cancer

Vasoconstrictor Agents

Respiratory System Agents

All Drugs and Chemicals

Cardiotonic Agents

Vasodilator Agents

Epinephrine

Norepinephrine

Dobutamine

Racepinephrine

Epinephryl borate

Sympathomimetics

Dopexamine

Adrenergic Agents

Adrenergic alpha-Agonists

Adrenergic Agonists

Neurotransmitter Agents

Adrenergic beta-Agonists

Bronchodilator Agents

Anti-Asthmatic Agents

Mydriatics

Protective Agents

Dopamine

Dopamine Agonists

Dopamine Agents

Epinephrine, Norepinephrine, Dobutamine, Dopexamine

0.2mcg/kg/min maximum infusion; to increase mean arterial pressure by 30mmHg

Maximum infusion of 0.2mcg/kg/min, to increase mean arterial pressure by 30mmHg

Maximum infusion rate of 8mcg/kg/min to increase mean arterial pressure by 30mmHg

Maximum infusion rate of 5mcg/kg/min to increase mean arterial pressure by 30mmHg

Stephen R Watt-Smith, FDSRCS, MD

Following surgery to remove tumours of the head and neck, patients undergo reconstruction with free flaps - tissue that is taken from elsewhere in the body and given a new blood supply by attaching it to vessels in the neck. Following this type of surgery, patients often need medication to maintain their blood pressure in the intensive care unit. The effect of these drugs on the transplanted tissues is unknown. This study investigates the effects of four commonly used drugs on free flap perfusion.

The optimal sympathomimetic drug to support blood pressure without adverse vasoconstriction of free flap circulation remains unknown. This study examined the effects of four agents (epinephrine, norepinephrine, dobutamine and dopexamine) on free flaps following resection of head and neck cancer.

Twenty five patients were recruited to the study. Each patient received an infusion of the four drugs in a random order with an intervening washout period between drugs, at four infusion rates. Continuous free flap skin blood flow monitoring was performed using laser Doppler velocimetry, with a second sensor on normal skin acting as a control. Global cardiovascular variables were monitored using the LiDCO Rapid pulse contour analysis system.

Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery

An Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery: A Randomised Study

Oxford University Hospitals NHS Trust

Mr SR Watt-Smith

Skin and Connective Tissue Diseases

Symptoms and General Pathology

Nervous System Diseases

Ganglion Cysts

Headache

Post-Dural Puncture Headache

Synovial Cyst

Cysts

Pain

Neurologic Manifestations

Mucinoses

Connective Tissue Diseases

Neoplasm Metastasis

Headache Disorders

Headache Disorders, Secondary

Brain Diseases

Central Nervous System Diseases

Anti-Arrhythmia Agents

Channel Blockers

Central Nervous System Depressants

Anti-Inflammatory Agents

Antirheumatic Agents

Analgesics

Lidocaine

Diclofenac

Patients will receive paracetamol 1 gm every 6 hours daily intravenously for a day.

Patients will receive sphenopalatine block

Sphenopalatine Ganglion Block will be performed by a transnasal approach. Few drops of lidocaine 2% will be instilled into both anterior nares. Then a cotton-tipped applicator soaked in 4% lignocaine \& adrenaline (1 to 200000 will be passed through both the nares and the end of the applicator tip will be positioned just superior to the middle turbinate and anterior to the pterygopalatine fossa and sphenopalatine ganglion for 5 min with the patient in the supine position.

Sphenopalatine Ganglion Block

Patients will receive paracetamol 1 gm 6 hours daily intravenously for a day. If adequate pain relief will not be achieved, intravenous diclofenac 75 mg twice daily will be added.

Medical Treatment

The aim of this study is to assess the efficacy, onset and duration of analgesia of sphenopalatine ganglion bock (SPGB) using lidocaine 4% with adrenaline as a treatment of postoperative Post dural puncture headache (PDPH) of orthopedic patients after lower limbs surgeries.

Sphenopalatine Ganglion Block for Post-Dural Puncture Headache in Orthopedic Patients

Sphenopalatine Ganglion Block With Adrenaline Additive for Post-Dural Puncture Headache in Orthopedic Patients: A Randomized Controlled Study

The data will be available upon reasonable request

Efficacy of analgesia demonstrated by visual analogue scale (VAS) less than 4 (effective) in the first 48 hours.

VAS ranges from 0 to 10; 10 with worse outcome

Local anesthetic toxicity, hypertension, postoperative epistaxis, cheek hematoma and hypoesthesia of the palate

Tanta University

Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery	NCT01418118	Oral Cancer Head and Neck C... Free Flap Hypotension	Epinephrine Norepinephrine Dobutamine Dopexamine	17 Years -	Oxford University Hospitals NHS Trust
Sphenopalatine Ganglion Block for Post-Dural Puncture Headache in Orthopedic Patients	NCT04657952	Sphenopalatine ... Adrenaline Post-Dural Punc... Orthopedic Randomized Cont...	Sphenopalatine ... Medical Treatme...	18 Years - 60 Years	Tanta University

Spots Global Cancer Trial Database for adrenaline

Every month we try and update this database with for adrenaline cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for adrenaline

Every month we try and update this database with for adrenaline cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for adrenaline cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.