Neoplasms

Digestive System Diseases

All Conditions

Colonic Neoplasms

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Other Dietary Supplements

All Drugs and Chemicals

Whey Protein

Subjects will receive an oral nutrition regimen comprised of 50% of their Resting Energy Expenditure (REE) as dextrose and 20% of their REE as pressurized whey protein

Subjects will receive a peripheral parenteral nutrition (PPN) regimen comprised of 50% of their Resting Energy Expenditure (REE) as dextrose and 20% of their REE as amino acids.

Ten (10) subjects will be randomly assigned to receive an oral nutrition regimen comprised of 50% of their REE as dextrose and 20% of their REE as pressurized whey protein. Subjects will undergo a six-hour stable isotope infusion protocol one day before surgery (to obtain baseline data) and on the first post-operative day. During both infusion protocols, subjects will be asked to carry out their assigned oral nutrition regimen. To minimize fasting during the perioperative period all subjects will receive peripheral parenteral nutrition (PPN) at the time of surgical incision until the first postoperative day.

Oral Nutrition with dextrose and pressurized whey protein

Ten (10) subjects will be randomly assigned to receive peripheral parenteral nutrition (PPN) regimen comprised of 50% of their REE as dextrose and 20% of their REE as amino acids. Subjects will undergo a six-hour stable isotope infusion protocol one day before surgery (to obtain baseline data) and on the first post-operative day. During both infusion protocols, subjects will be asked to carry out their assigned PPN regimen. To minimize fasting during the perioperative period all subjects will receive PPN at the time of surgical incision until the first postoperative day.

Peripheral Parenteral Nutrition

Franco Carli, M.D.

A prospective, randomized controlled study, using stable isotope methodology, is proposed to determine whether an oral nutrition support regimen, containing pressurized whey protein and glucose, is more effective at normalizing the metabolic response to surgery than a standard peripheral parenteral nutrition (PPN) support regimen, containing amino acids and glucose, in colorectal surgical patients studied before and after surgery. The effectiveness of the nutrition support regimens will be determined by: whole body protein balance, synthesis rates of hepatic secretory proteins, resting energy expenditure and substrate utilization, as well as circulating metabolites concentrations.

Oral Versus Parenteral Nutrition Support to Improve Protein Balance in Colorectal Surgical Patients

Oral Versus Parenteral Perioperative Nutrition Support to Improve Protein Balance: Stable Isotope Study in Colorectal Surgical Patients

Whole body protein balance (the difference between protein synthesis and protein breakdown) as assessed by the kinetics of a stable, non-radioactive, isotope tracer infusion of L-\[1-13C\] leucine

Synthesis rates of hepatic secretory proteins, including the classically positive acute phase reactant fibrinogen and the classically negative acute phase reactant albumin, as assessed by incorporation of the stable, non-radioactive, isotope tracer L-\[2H5\] phenylalanine into plasma Very Low Density Lipoprotein ApolipoproteinB100.

Montreal General Hospital

McGill University

McGill University Health Centre/Research Institute of the McGill University Health Centre

Dr. Franco Carli

Infections

Blood and Lymph Conditions

Symptoms and General Pathology

Rare Diseases

Epstein-Barr Virus Infections

Virus Diseases

Lymphohistiocytosis, Hemophagocytic

Communicable Diseases

Herpesviridae Infections

DNA Virus Infections

Tumor Virus Infections

Histiocytosis

Histiocytosis, Non-Langerhans-Cell

Lymphatic Diseases

Non-Langerhans-Cell Histiocytosis

Antineoplastic Agents

Anti-Inflammatory Agents

Antiemetics

Neuroprotective Agents

Gastrointestinal Agents

Etoposide

Doxorubicin

Liposomal doxorubicin

Prednisolone

Etoposide phosphate

Methylprednisolone

Methylprednisolone Acetate

Methylprednisolone Hemisuccinate

Prednisolone acetate

Prednisolone hemisuccinate

Prednisolone phosphate

Epstein-Barr virus associated hemophagocytic lymphohistiocytosis patients with imaging confirmed intestinal involvement

Segmental bowel resection combined with liposomal doxorubicin, etoposide, and methylprednisolone administered in 2 week cycles for 2 cycles

Segmental bowel resection combined with the DEP regimen

Zhao Wang, MD

EBV-HLH is a rare disease with high mortality, especially for those with intestinal involvement. In order to reduce disease burden and improve survival of these patients, we conduct a prospective observational study to explore the efficacy and safety of segmental resection combined with the DEP regimen.

Epstein-Barr virus associated hemophagocytic lymphohistiocytosis is a rare disease with high mortality, especially for those with intestinal involvement. Some of them still died despite early control of the disease due to severe complications, such as gastrointestinal bleeding. In order to reduce disease burden and improve survival of these patients, we conduct a prospective observational study to explore the efficacy and safety of segmental resection combined with the DEP regimen.

Segmental Resection Combined With DEP Regimen for EBV-HLH Patients With Intestinal Involvement

Efficacy and Safety of Segmental Resection Combined With the DEP Regimen for Epstein-Barr Virus Associated Hemophagocytic Lymphohistiocytosis With Intestinal Involvement

The percentage of cases that achieved complete response (CR) and partial response (PR) after treatment.

Beijing Friendship Hospital

Professor and Head of hematology

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Oral Versus Parenteral Nutrition Support to Improve Protein Balance in Colorectal Surgical Patients	NCT01222208	Colon Cancer	Oral Nutrition ... Peripheral Pare...	18 Years - 85 Years	McGill University Health Centre/Research Institute of the McGill University Health Centre
Segmental Resection Combined With DEP Regimen for EBV-HLH Patients With Intestinal Involvement	NCT06131489	Hemophagocytic ... Epstein-Barr Vi... Bowel Resection	Segmental bowel...	18 Years -	Beijing Friendship Hospital
Segmental Resection Combined With DEP Regimen for EBV-HLH Patients With Intestinal Involvement	NCT06131489	Hemophagocytic ... Epstein-Barr Vi... Bowel Resection	Segmental bowel...	18 Years -	Beijing Friendship Hospital
Oral Versus Parenteral Nutrition Support to Improve Protein Balance in Colorectal Surgical Patients	NCT01222208	Colon Cancer	Oral Nutrition ... Peripheral Pare...	18 Years - 85 Years	McGill University Health Centre/Research Institute of the McGill University Health Centre

Spots Global Cancer Trial Database for bowel resection